postman
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- Mar 3, 2016
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The funny thing is most middle eastern countries use this as a sprinkle over baked goods like sesame on burger buns in the west.
"[...] pharmacological activation of NRF2 is a promising therapeutic approach for several chronic diseases that are underlined by oxidative stress and inflammation, such as neurodegenerative, cardiovascular, and metabolic diseases. A particular case is cancer, where NRF2 confers a survival advantage to constituted tumors, and therefore, NRF2 inhibition is desired."
Good research ! Are you still talking this ?I know it isn’t very “Peaty” here because it contains PUFAs. Yet, the phytonutrients in this seed more than make up for it by strongly protecting against oxidative stress, lipid peroxidation, and assisting energy production. The main ingredient seems to be thymoquinone, a quinone obviously, but the whole seed usually works better than this single compound.
In this post though, I’m just going to post studies as it relates to thyroid hormone / function, because there are plenty. (Keep in mind, most of the human studies just used the ground seeds at 1g x 2 a day, but the most effective case series (image below) used 5g x 2 a day.
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http://ijrar.org/papers/IJRAR1944176.pdf
Effect of Safoof-e-kalonji (Nigella sativa) in the Managament of Subclinical Hypothyroidism
(Pre / Post values taken about a month apart) 10g total per day, seeds
View attachment 17540
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https://www.researchgate.net/publication/310468405_The_effects_of_Nigella_sativa_on_thyroid_function_serum_Vascular_Endothelial_Growth_Factor_VEGF_-_1_Nesfatin-1_and_anthropometric_features_in_patients_with_Hashimoto's_thyroiditis_A_randomized_control
The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: A randomized controlled trial
2g total per day, seed
View attachment 17541
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https://www.researchgate.net/publication/297750663_Nigella_Sativa_treatment_and_serum_concentrations_of_thyroid_hormones_transforming_growth_factor_b_TGF-b_and_interleukin_23_IL-23_in_patients_with_Hashimoto's_Thyroiditis
Nigella Sativa treatment and serum concentrations of thyroid hormones, transforming growth factor β (TGF-β) and interleukin 23 (IL-23) in patients with Hashimoto’s Thyroiditis
2g total per day, seed
View attachment 17542
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Effects of Nigella sativa L. Seed Extract on Fatigue, Blood Biochemical Parameters and Thyroid Function in Male Mice
Rodent study. Hydroalcoholic extract, so much higher human-equivalent doses than used in the human studies (doses listed below the table, highest dose would equal 2.8g of this “extract” for a large 91kg human.
View attachment 17543
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Here’s a couple more:
- Can nigella sativa oil (nso) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies | Request PDF
Can nigella sativa oil (nso) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies
- Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits | Request PDF
Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits
- Study the effect of Nigella Sativa on thyroid function and reproductive hormone of female rat | Journal of Contemporary Medical Sciences
“Twelve females rats were used and divided randomly into two groups (6 animals for each) first group served as treatment and gave Nigella sativa oil (1ml /kg BW/day ) orally according to body weight for a period of 30 consecutive days. While other group drenched with normal saline at same dose that above mentioned and served as control.Results The result revealed significant increase in levels of LH, Estrogen T3 and T4 and significant decrease in level of TSH. Histological sections of thyroid gland revealed presence vaculation in colloid of thyroid follicle.Conclusion In conclusion, the Nigella sativa oil caused the elevation of thyroid hormones as well as LH and estrogen but still within normal value.”
Discussion: “Thyroid gland of female rats treated with Ns showed no histological changes when compare with the control except that some of the follicles were enlarged and containing vacuolated colloid as appear from Figure 2. This might be attributed to increased endocytotic activity of many follicular cells reflecting a compensatory mechanism to the augmented release of the stored hormones in the follicular lumen.”
- THE PROTECTIVE ROLE OF NIGELLA SATIVA OIL (NSO) AGAINST THYROID ULTRASTRUCTURAL CHANGES INDUCED BY EXPOSURE TO DI (2-ETHYLHEXYL) PHTHALATE (DEHP) | Request PDF
THE PROTECTIVE ROLE OF NIGELLA SATIVA OIL (NSO) AGAINST THYROID ULTRASTRUCTURAL CHANGES INDUCED BY EXPOSURE TO DI (2-ETHYLHEXYL) PHTHALATE (DEHP)
- [PDF] Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. | Semantic Scholar (Human study)
Lastly, this one isn’t thyroid-related, but this before and after treatment chart is just kinda insane.
(750mg x 2 a day, seed)
View attachment 17544
No one says you have to rely on it . It even if you did I dont see problem with it .Well I can’t imagine being on Thyroid for a while or even for a lifetime, I can’t really imagine being on an herb that long. There are just too many issues with that. It’s fine for occasional use or for short intervals but I can’t imagine relying on an herb for the duration. I can however easily imagine using intelligent T4 or T3 supplementation.
HI, any succes?There is 1.5 g max of total fat in 5g of ground seeds. I just feel like focusing on the PUFAs in this situation is missing the forest for the trees.
It was part of my mix that increased my T3 to its highest ever levels and reduced TSH to its lowest. Not perfect yet, but moving in the right direction for sureHI, any succes?
would you share your mix please?It was part of my mix that increased my T3 to its highest ever levels and reduced TSH to its lowest. Not perfect yet, but moving in the right direction for sure
Nice summary, thank you!Black Seed Oil and Hashimoto's - Dr. Izabella Wentz
Black seed oil has been touted as a “cure for everything except for death!” - so can it be beneficial for Hashimoto's? Read on to find out more!thyroidpharmacist.com
Nice find! Thank youBlack cumin improves sleep quality a lot in this human study. Also lowers cortisol levels.
- A proprietary black cumin oil extract ( Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study - PubMed
All my thyroid markers improved while on it, and returned to previous levels after stopping it.Does one stop cold turkey if one’s labs show desired results?
Is it fair to assume you’re back to taking it?All my thyroid markers improved while on it, and returned to previous levels after stopping it.
I will resume it tomorrow lolIs it fair to assume you’re back to taking it?
If so, are you taking the oil or the whole seeds? Dose?
Thank you
Random thing but they do have the capital grille line of restaurants here in the states… they also released capital burger line of restaurants. Its not organic or grass fed but supposedly higher quality burger meat like steak meat perhaps angus beef. Their burger bun’s actually have black seeds on them instead of sesame seeds! Although i dont know if its nigella sativa as I believe theres another common black seed used as a topping maybe black caraway seeds or something?The funny thing is most middle eastern countries use this as a sprinkle over baked goods like sesame on burger buns in the west.