Nigella Sativa (Black Seed) Consistently Is Beneficial For Thyroid Function

Discussion in 'Scientific Studies' started by zarrin77, Apr 23, 2020.

  1. zarrin77

    zarrin77 Member

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    I know it isn’t very “Peaty” here because it contains PUFAs. Yet, the phytonutrients in this seed more than make up for it by strongly protecting against oxidative stress, lipid peroxidation, and assisting energy production. The main ingredient seems to be thymoquinone, a quinone obviously, but the whole seed usually works better than this single compound.

    In this post though, I’m just going to post studies as it relates to thyroid hormone / function, because there are plenty. (Keep in mind, most of the human studies just used the ground seeds at 1g x 2 a day, but the most effective case series (image below) used 5g x 2 a day.

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    http://ijrar.org/papers/IJRAR1944176.pdf
    Effect of Safoof-e-kalonji (Nigella sativa) in the Managament of Subclinical Hypothyroidism

    (Pre / Post values taken about a month apart) 10g total per day, seeds
    D6102D47-F2E5-4B2B-AB3A-7EDB5EA86E51.png

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    https://www.researchgate.net/public..._Hashimoto's_thyroiditis_A_randomized_control

    The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: A randomized controlled trial

    2g total per day, seed
    D8D4E63A-433B-476E-9562-C291A561C8BF.jpeg

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    https://www.researchgate.net/public...L-23_in_patients_with_Hashimoto's_Thyroiditis

    Nigella Sativa treatment and serum concentrations of thyroid hormones, transforming growth factor β (TGF-β) and interleukin 23 (IL-23) in patients with Hashimoto’s Thyroiditis

    2g total per day, seed
    86837871-E00E-4422-8228-7B928E6C3979.jpeg

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    Effects of Nigella sativa L. Seed Extract on Fatigue, Blood Biochemical Parameters and Thyroid Function in Male Mice

    Rodent study. Hydroalcoholic extract, so much higher human-equivalent doses than used in the human studies (doses listed below the table, highest dose would equal 2.8g of this “extract” for a large 91kg human.
    CA98B580-C317-4451-ABA4-E14CCFC1C858.jpeg

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    Here’s a couple more:
    - https://www.researchgate.net/public...U_in_rat_biochemical_and_histological_studies

    Can nigella sativa oil (nso) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies
    - https://www.researchgate.net/public...d_glucose_in_alloxan-induced_diabetic_rabbits

    Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits

    - Study the effect of Nigella Sativa on thyroid function and reproductive hormone of female rat | Journal of Contemporary Medical Sciences

    “Twelve females rats were used and divided randomly into two groups (6 animals for each) first group served as treatment and gave Nigella sativa oil (1ml /kg BW/day ) orally according to body weight for a period of 30 consecutive days. While other group drenched with normal saline at same dose that above mentioned and served as control.Results The result revealed significant increase in levels of LH, Estrogen T3 and T4 and significant decrease in level of TSH. Histological sections of thyroid gland revealed presence vaculation in colloid of thyroid follicle.Conclusion In conclusion, the Nigella sativa oil caused the elevation of thyroid hormones as well as LH and estrogen but still within normal value.”

    Discussion: “Thyroid gland of female rats treated with Ns showed no histological changes when compare with the control except that some of the follicles were enlarged and containing vacuolated colloid as appear from Figure 2. This might be attributed to increased endocytotic activity of many follicular cells reflecting a compensatory mechanism to the augmented release of the stored hormones in the follicular lumen.”

    - https://www.researchgate.net/public...BY_EXPOSURE_TO_DI_2-ETHYLHEXYL_PHTHALATE_DEHP

    THE PROTECTIVE ROLE OF NIGELLA SATIVA OIL (NSO) AGAINST THYROID ULTRASTRUCTURAL CHANGES INDUCED BY EXPOSURE TO DI (2-ETHYLHEXYL) PHTHALATE (DEHP)

    - [PDF] Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. | Semantic Scholar (Human study)

    Lastly, this one isn’t thyroid-related, but this before and after treatment chart is just kinda insane.
    (750mg x 2 a day, seed)

    F88887FD-68F3-4925-8419-F8D8587F82A6.jpeg
     
  2. OP
    zarrin77

    zarrin77 Member

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  3. GenericName86

    GenericName86 Member

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    So the seeds are better to consume than the oil? I read black seed oil can raise brain levels of serotonin
     
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    zarrin77

    zarrin77 Member

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    We don’t know, becuase none of the studies tested the oil form. All human studies just used the seeds ground up.

    I know about the serotonin study as well. Yet, as far as thyroid goes, black seed is very beneficial regardless.
     
  5. SOMO

    SOMO Member

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    The beneficial component in Black Seed are the Quinones.

    Why not just consume another Quinone and then you won't have to drink nasty oil + unnecessary PUFA + unnecessary calories?
     
  6. OP
    zarrin77

    zarrin77 Member

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    For sure you can. Nootropics Depot has just that type of extract if that’s what you want.

    For me, I just want to follow what the studies did. Much of the time, compounds in herbs act synergistically. There are likely many other active compounds in black seed, including p-cymene, carvacrol, 4-terpineol, t-anethol, sesquiterpene longifolene, α-pinene, thymol etc.

    While many studies show that thymoqunione supplementation gets good effects, it also has a higher toxicity (at the same relative dosage) than the whole seed or full spectrum extract.

    Why not consume another quinone? I’m not aware of other quinones having this type of consistent evidence for thyroid function. If you have some studies about this, please send it my way. Black seeds have also been used for thousands of years and have a very low toxicity. I also just eat 3-5 g of freshly ground seeds at a time, so very low calorie and relatively low PUFA.
     
  7. RealNeat

    RealNeat Member

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    The oil was used to stabilize other PUFAs, it seems much more protective than your average vitamin E depleted PUFA.
     
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    zarrin77

    zarrin77 Member

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    There is 1.5 g max of total fat in 5g of ground seeds. I just feel like focusing on the PUFAs in this situation is missing the forest for the trees.
     
  9. SOMO

    SOMO Member

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    1. All of those terpenes/essential oil volatile compounds can be found in other herbs (oregano, pine, thyme, anise and cannabis) that do not require the consumption of oils.


    2. All quinones act as electron acceptors in redox reactions, this is a universal trait of quinones and is not limited to the quinones in Black Seed.

    3. I'm not sure about any specific thyroid benefit from the other quinones, but I do know that Thyroid function is involved in blood clotting and Vitamin K - which is a Quinone - corrects blood clotting issues (over-clotting or lack of clotting. This article links 3 studies.
    Vitamin K and Thyroid Health

    Effects of the hormones of the thyroid axis on the vitamin K-dependent plasma factors of blood coagulation (II, VII, IX, and X). - PubMed - NCBI
    So there seems to be an intimate relationship between the thyroid hormones, the pituitary hormones which stimulate thyroid hormone production and Vitamin K/Quinone.

    Clinical review: Thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review. - PubMed - NCBI
    This study doesn't mention quinones, it just mentions the thyroid's effect on blood coagulation, which is not negligible. One would logically expect Vitamin K to have a balancing effect on blood clotting.

    4. Also PQQ, another quinone, seems to reduce the negative effects of T4 supplementation
    Pyrroloquinoline quinone ameliorates l-thyroxine-induced hyperthyroidism and associated problems in rats. - PubMed - NCBI


    To clarify, my main point is just that you can get all of Black Seed's benefit (seed or oil) from other compounds.

    Also many people on this forum are trying to lose weight, and consuming extra calories in the form of oil will not help them and the small decrease in TSH will not be enough to restore metabolism. Speaking of which, those post-Black Seed TSH levels are still high.
     
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    zarrin77

    zarrin77 Member

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    I appreciate the research. I agree that the quinones are the main drivers. Yet, animal studies that compare thymoquinone alone vs. nigella sativa extract shows that they do not usually get the same results.

    While both thymoquinone and vitamin K are quinones, they still have quite different structures (attached) that may affect absorption into different tissues or organelles such as the mitochondria. There are likely many overlapping functions, but they will not behave identically, and I’m not going to assume they will without something more than hypothesis baking that up. And afaik, only one of these has shown benefits for thyroid function (repeatedly).

    Black seed has repeatedly been shown to help with weight loss
    The Effects of Nigella Sativa L. On Obesity: A Systematic Review and Meta-Analysis - PubMed
    And like I said above, at the *highest dose used* in the studies I cited in the OP, 10g a day, that would be a whopping 56 calories and 3g of total fat... This is not going to hinder anyone’s weight loss. (I have never suggested drinking the oil).

    For the Hashimoto’s patients, they used 2g a day, a total of around 11 calories..
     

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  11. OP
    zarrin77

    zarrin77 Member

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    Also, yes the TSH levels were still high. Yet, besides one human study using high dose vitamin A and a couple studies using Ashwagandha, I can’t think of another nutraceutical that consistently drops the TSH with such magnitude. It is unlikely you are going to 100% fix thyroid function with one supplement without lifestyle changes, etc. If you know of some other supplement that can drop TSH like this (with human RCTs to confirm), please let me know, as I’d want to look into them.
     
  12. RealNeat

    RealNeat Member

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    I agree with this, it's effective at culinary doses, that's pretty epic.
     
  13. papaya

    papaya Member

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    what dose do you take, teaspoon, tablespoon? i have the seeds & i take a random spoonful every once in a while. they're old so i'm gonna get new ones but they don't taste rancid. they're not an oily seed.
     
  14. postman

    postman Member

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    There is no "making up for" shutting down mead acid production. But looking at nutritional charts the amount of PUFA you would get from consuming 5g of ground seeds is neglible, it's not even relevant. According to google (lets hope it's accurate) the percentage of PUFA of the total amount of nigella sativa seed fat is about 11.5%.

    1.5 x 0.115 = 0.1725

    So you get roughly 0.1725 grams of pufa from consuming your 5g dose of nigella sativa.

    The serotonin thing could be of real concern however.
     
  15. OP
    zarrin77

    zarrin77 Member

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    This is why I’ve been saying don’t be scared off by the tiny little PUFA. Otherwise, you should be just as scared, or more, to eat an egg.

    Serotonin, possibly. It seems it is specific based on which part of the brain you are looking at. I saw a study yesterday where black seed actually lowered serotonin. So, this will need more research.
     
  16. postman

    postman Member

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    You should be scared to eat eggs, Ray says don't eat more than 1-2 per day. And if you do decide to eat 1-2 eggs per day then that's going to be a big part of your PUFA budget, if you want to be "deficient". Could you please link the serotonin lowering study btw
     
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    zarrin77

    zarrin77 Member

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    I get the egg thing, it was a counter example I was trying to point out. The point is that the PUFA load from 5g of black seed is very small.

    I think it was this one: Neurochemical and Behavioral Effects of Nigella Sativa and Olea Europaea Oil in Rats - PubMed
    Image below. Small dose (as we would likely be using) decreased serotonin. Large dose increased it. This study also shows that the lower dose of olive oil increased serotonin too.

    3283DFCA-97C1-40FB-B723-EAB20A66B685.jpeg
     
  18. postman

    postman Member

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    Very interesting. Can this be used as a spice on food?
     
  19. OP
    zarrin77

    zarrin77 Member

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    Yeah if you happen to like the taste. There are many traditional dishes that incorporate it.

    I usually just grind the seeds, mix them with honey, and eat with a spoon. Sometimes I make a tea from the ground seeds which is actually pretty good.
     
  20. RealNeat

    RealNeat Member

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    The funny thing is most middle eastern countries use this as a sprinkle over baked goods like sesame on burger buns in the west.
     
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