Lisuride worsens OCD somehow?

[lateralus]

I've been taking Lisuride for a few days now and I'm liking its anti-anhedonic effect but God does it make the OCD much worse. I have treatment-resistant OCD and I take Clomipramine for it, but ever since I've added Lisuride I've been getting thought loops more often than what I'm used to and intrusive thoughts in general. What mechanism is at play for this? I'm guessing its the 5HT1B agonism but not sure. Thoughts?

 

[Mr Joe]

My guess is that you are feeling the good part from lisuride effect on dopamine but you need to antagonize serotonin long enough to "reverse" the receptors. If you suffer from OCF it probably mean that your dopaminergic receptors are disregulated and serotonine is high. Go slow on lisuride but long enough to recalibrate dopaminergic receptors. The more sensitive will be your receptors, the best it will be, the less serotonin will be secreted. OCD is a low dopamine issue. On the mean time I advice you to check everything else : Protein intake, high calcium and SODIUM ! Magnesium is important as well !

 

[lateralus]

Can you show me a source for the "OCD is a low dopamine issue"? And I eat lots of protein daily. My Magnesium is in normal range. Assuming OCD is a low dopamine issue, wouldn't 9-Me-BC be great? Just a thought

 

[Mr Joe]

It's all seorotonin/cortisol/stress related : Anxiety, depression, OCD etc... see for example :

High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate ...

www.ncbi.nlm.nih.gov

Glycine is a cortisol inhibitor so inhibiting cortisol helps inhibiting serotonin and if you inhibit serotonin you increase dopamine and GABA, improve thyroid and thus global oxidative mechanisme and you feel well. I don't know for 9-Me-BC but it's quite usual that anxious people with high seorotonin and low dopamin experience OCD as well.

 

[LazloC]

I have the same issue with OCD and am going off of SSRI currently. Would it be ok to use lisuride with 5-methoxy-hamalate to address the serotonin side as well as the dopaminergic side?

 

[lateralus]

I have the same issue with OCD and am going off of SSRI currently. Would it be ok to use lisuride with 5-methoxy-hamalate to address the serotonin side as well as the dopaminergic side?

Well on paper there shouldn't be any interaction but who knows. If you do try it update me please.