Is It Possible To Open Epiphyseal Growth Plate?

[JamesGatz]

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[Vajra]

One would likely have to be in peak health. It's not necessarily uncommon for the people to grow a few inches in their early 20s when their growth plates were supposedly closed.

I don't know if I've ever read an anecdote of 100% healthy average people growing after their plates were confirmed to be closed through HGH or whatever it may be.
Most men grow from when they hit puberty at ~11 and grow until ~16. Sure, if you hit puberty at like 16 or even later then you may see growth in your 20s but those anecdotes mean nothing regarding growth plates.
There's this site but the argument holds.

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[Drareg]

some interesting studies I came across-

Effect of fermented oyster extract on growth promotion in Sprague-Dawley rats - PubMed

FO have high content of GABA, and induced positive effects on body length, tibial length, growth-plate length and hepatic IGF-1 synthesis in SD rats with no toxicity or alterations of hematological profile. Therefore, these results suggest that GABA-enriched FO could be considered a potential...

pubmed.ncbi.nlm.nih.gov

Abstract​

Background: Oysters (Crassostrea gigas) are a popular marine product worldwide and have the advantage of nutritional benefits. This study aimed to investigate the effect of fermented oyster extract (FO) on growth promotion, including analysis of body size, bone microarchitecture, hematology and biochemistry in vivo.
Methods: The amount of nutrients and gamma aminobutyric acid (GABA) were determined. Sprague-Dawley rats were randomly divided into four groups: the control group, FO 50 group (FO 50 mg/kg), and FO 100 group (FO 100 mg/kg) were administered orally once daily and the recombinant human growth hormone (rhGH) group (200 μg/kg) was intraperitoneally injected once daily for 14 days.
Results: Oral administration of FO 100 significantly increased body length and had no effect on organ damage or hematological profiles. However, administration of rhGH significantly induced hypertrophy of the liver, kidney and spleen along with a marked increase in body length. Tibia length and the growth plate were increased, and bone morphometric parameters were slightly improved by FO and rhGH administration. Serum analysis showed that the levels of GH and insulin like growth factor-1 (IGF-1) were slightly upregulated by FO administration. Nevertheless, the protein expression of hepatic IGF-1 was markedly increased by FO 100 and rhGH administration.
Conclusions: FO have high content of GABA, and induced positive effects on body length, tibial length, growth-plate length and hepatic IGF-1 synthesis in SD rats with no toxicity or alterations of hematological profile. Therefore, these results suggest that GABA-enriched FO could be considered a potential alternative treatment for growth stimulation.
Keywords: Fermented oyster (FO); Gamma aminobutyric acid (GABA); Insulin like growth factor-1; Recombinant human growth hormone (rhGH); Tibial growth plate.

Efficacy and safety of fermented oyster extract for height of children with short stature: a randomized placebo-controlled trial - PubMed​

Abstract​

Background: Some experimental studies have established the effect of oysters on the promotion of body growth. Yet, there is a lack of human clinical studies. The objective of this study was to evaluate the effect of a fermented oyster (FO) extract on the increase in the height of children with stature in the 25th percentile by age.
Methods: In total, 100 children (6-11 years old) were randomly divided into two (FO or control) groups. For 24 weeks, the subjects in the FO group took the FO extract once daily before sleeping, whereas the control group took placebo extracts, simultaneously. We evaluated the height gain, height velocity (HV), height standard deviation score (SDS), urine deoxypyridinoline (DPD), growth hormone (GH), insulin-like growth factor (IGF-1), and IGF binding protein 3 (IGFBP-3).
Results: The height gain and height SDS were significantly higher in the FO group than in the placebo group after 24 weeks (height gain: p < 0.001, height SDS: p < 0.005). The HV was also significantly higher in the FO group than in the placebo group after the 6th and 24th week (p = 0.001, p = 0.004). After 24 weeks, we observed a decrease in GH, IGF, and IGFBP-3 in both groups. However, serum IGFBP-3 level in the FO group reduced less than placebo group.
Conclusion: FO supplementation may help to increase the height of children, and the effect might be mediated via effects on the IGFBP-3 levels.