Insects Can Feel Both Acute And Chronic Pain, Can Even Develop Insect-PTSD

haidut

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Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of sociopath to make that claim in the face of screaming, writhing babies getting operated on, getting needles inserted in the spinal cavity, having caustic skin procedures, etc. And while some scientists have spoken against treating babies like mindless, numb matter even those scientists usually readily subscribe to the theory that lower-level animals most certainly do not feel any pain. For that reason, vivisection on live animals is considered completely justified.
Well, the study below begs to disagree. It shows that animals as "primitive" as insects can feel both acute and chronic pain. Moreover, in the case of chronic pain the insect may even develop something akin to PTSD where they become hypervigilant and hypersensitive to their environment and perceive danger everywhere, all the time. Seeing studies like this makes me think that maybe the insensitive doctors making comments about lack of pain in others should get operated on without anesthesia. For the old Latin saying goes "eventus stultorum magister" - only experience can teach/change fools.
On a more positive note, the study found that chronic neuropathic pain is the result of loss of pain "brakes" - inhibitory signals in the nervous system that act to control/limit pain signals entering the CNS for processing. This finding suggests that loss of GABA/glycine signalling may be the cause of chronic pain in humans and this matches quite well the lifelong decrease of GABA and glycine signalling starting in the early 30s. A person in their 80s probably has only half of ability to respond to GABA/glycine and this allows excitatory signals to rule unchecked. No wonder old people can never relax and despite being always tired they cannot sleep deeply and the vast majority of them do report feeling some kind of chronic pain. Maybe the solution is as simple as eating gelatin on a daily basis or using some progesterone...

https://www.cell.com/abstract/S0092-8674(03)00272-1
Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila
Thwack! Insects feel chronic pain after injury

"...Scientists have known insects experience something like pain since 2003, but new research published today from Associate Professor Greg Neely and colleagues at the University of Sydney proves for the first time that insects also experience chronic pain that lasts long after an initial injury has healed. The study in the peer-reviewed journal Science Advances offers the first genetic evidence of what causes chronic pain in Drosophila (fruit flies) and there is good evidence that similar changes also drive chronic pain in humans. Ongoing research into these mechanisms could lead to the development of treatments that, for the first time, target the cause and not just the symptoms of chronic pain."

"...In the study, Associate Professor Neely and lead author Dr Thang Khuongfrom the University’s Charles Perkins Centre, damaged a nerve in one leg of the fly. The injury was then allowed to fully heal. After the injury healed, they found the fly’s other legs had become hypersensitive. “After the animal is hurt once badly, they are hypersensitive and try to protect themselves for the rest of their lives,” said Associate Professor Neely. “That’s kind of cool and intuitive.”

“The fly is receiving ‘pain’ messages from its body that then go through sensory neurons to the ventral nerve cord, the fly’s version of our spinal cord. In this nerve cord are inhibitory neurons that act like a ‘gate’ to allow or block pain perception based on the context,” Associate Professor Neely said. “After the injury, the injured nerve dumps all its cargo in the nerve cord and kills all the brakes, forever. Then the rest of the animal doesn’t have brakes on its ‘pain’. The ‘pain’ threshold changes and now they are hypervigilant.”

“Animals need to lose the ‘pain’ brakes to survive in dangerous situations but when humans lose those brakes it makes our lives miserable. We need to get the brakes back to live a comfortable and non-painful existence.” In humans, chronic pain is presumed to develop through either peripheral sensitisation or central disinhibition, said Associate Professor Neely. “From our unbiased genomic dissection of neuropathic ‘pain’ in the fly, all our data points to central disinhibition as the critical and underlying cause for chronic neuropathic pain.” “Importantly now we know the critical step causing neuropathic ‘pain’ in flies, mice and probably humans, is the loss of the pain brakes in the central nervous system, we are focused on making new stem cell therapies or drugs that target the underlying cause and stop pain for good.”
 

Lecarpetron

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I realize this post is about insects, but regarding the first bit - I had serious surgery as a baby in the early 80's and just found out a few weeks ago that I likely did not receive full anesthesia during the procedure, only a paralytic agent. I've had severe insomnia, brain zaps, restless legs, and other signs of hypervigilance (about which I've posted about here) most of my adult life that I've on occasion temporarily "solved" with some strategy, gabapentin, etc. but always roar back with a vengeance. I'm having trouble finding information about withholding anesthesia from babies and the effects of doing so. May I ask, how did you find out about this @haidut ? Any suggestion for where I can learn more about it? Thanks x 100!!!!
 

haidut

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I realize this post is about insects, but regarding the first bit - I had serious surgery as a baby in the early 80's and just found out a few weeks ago that I likely did not receive full anesthesia during the procedure, only a paralytic agent. I've had severe insomnia, brain zaps, restless legs, and other signs of hypervigilance (about which I've posted about here) most of my adult life that I've on occasion temporarily "solved" with some strategy, gabapentin, etc. but always roar back with a vengeance. I'm having trouble finding information about withholding anesthesia from babies and the effects of doing so. May I ask, how did you find out about this @haidut ? Any suggestion for where I can learn more about it? Thanks x 100!!!!

I know it through both first hand experience and from doctor friends. It used to be pretty common practice until the end of the 1980s when it was officially criticized but never officially banned, so it continues to this day on a (slightly) smaller scale. It is basically left up to the treating doctor to decide and parents are almost never told about whether anesthetics will be used or not, quite obviously because they would probably object and block the surgery/procedure. I suspect that if more parents knew the full scope of torture their babies endure at the hands of the whitecoats, there would be mass murders across the world in neonatal units.
https://gizmodo.com/why-are-so-many-newborns-still-being-denied-pain-relief-1755495866
"...The press ran with the story, alerting Americans to the grim realization that hospitals in the United States routinely operated on critically ill premature babies without giving them painkillers. “Most adults would be shocked if they saw what was done to children in hospitals without anesthetics,” said Myron Yaster of Johns Hopkins in a subsequent Baltimore Sun article. “It’s like roping and holding down a steer to brand it.” Jeffrey’s parents took action, leading to the 1987 declaration by the American Academy of Pediatrics that it was no longer ethical to perform surgery on preterm babies without anesthetics. It’s been nearly 30 years since the AAP declaration, but to this day, many procedures are performed on newborns without the benefit of analgesics. That’s largely because of an enduring misconception in the medical community that newborns don’t feel pain like adults. Two years ago, a review of neonatal pain management in intensive care units(NICUs) in Europe found that newborn babies experience 11 painful procedures each day on average, but that 60 percent of these babies weren’t receiving any kind of pain relief. That’s in keeping with common practice in the United States and Britain, where less than 35 percent of infants undergoing painful procedures received any kind of analgesic to manage their pain. These procedures ranged in scope from the very mild, such as taking blood samples, to more invasive interventions, like chest tube insertions and circumcisions."
 

Jem Oz

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I do love your animal posts Georgi. They take the edge off work drudgery.

As for routine torture inflicted upon defenseless babies, it makes me think of the Jewish Brit Milah - the male circumcision that is traditionally performed without any anesthetic. It's an act of extreme, traumatic violence (sometimes with a depraved sexual element) that is considered beyond reproach by some because it's a high religious ceremony that's been around forever. Trauma is trauma in my books, and this act of barbarism should be outlawed in any civilized society.
 

anniejohnson

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Jul 9, 2019
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The Fly by William Blake:


Little fly,
Thy summer’s play
My thoughtless hand
Has brushed away.

Am not I
A fly like thee?
Or art not thou
A man like me?
...
 
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