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  1. A

    Belly Button Infection - Glutamate Connection?

    I had posted around 2 years ago how eating boiled shitake mushrooms brought about the worst Belly Button infection of my life (Attached photo will give you an idea). Its like a semi hard thing slowly trying to come out from my navel, and once it does it bursts out like a boil and carries pus...
  2. A

    Microdosing to reverse tolerance

    I found this very interesting thread that claim microdosing stimulants like amphetamine can long-term sensitize dopamine receptors View: https://www.reddit.com/r/Stims/comments/3mbp3n/be_very_careful_with_low_doses_of_stimulants/ ”In rats, dopaminergic supersensitivity from low-dosage...
  3. A

    Supplements/drugs for anxiety, ADD, OCD and rumination/overthinking

    I struggle with anxiety, ADD, OCD and rumination/overthinking. My cortisol, ACTH and prolactin is elevated (prolactin low after D2-agonist treatment). I think my main problems are low dopamine and low GABA. Which drugs and supplements do you recommend?
  4. haidut

    Human study - vitamin B6 may relieve anxiety and depression

    Vitamin B6 is perhaps one of the most underrated B vitamins. While it attracted a lot of interest in the 1960s and 1970s as a potential natural treatment to raise dopamine and/or lower prolactin, subsequent "well-controlled" studies claimed that it was not effective. However, the fact remains...
  5. C

    Does Theanine actually agonize GABA receptors / increase GABA? +Serotonin

    I've seen some people concerned with GABA rebound effects from l-theanine due to effects on increasing GABA. Theanine is commonly mentioned as a gaba agonist. 1. Does it actually have significant effects on GABA that would lead to rebound? 2. Would a daily gram amounts be safe for potential...
  6. UG Krishnamurti

    Glycine side effects. Could someone explain?

    After experimenting with glycine last night (1g in OJ) I've heard a LOUD screaming in my ear while I was sleeping. Woke me up and scared the sh*tout of me xd Knew it was "in my head" because my extremely alert dog was sleeping. I also woke up with extremely dry mouth, grogginess and fatigue...
  7. haidut

    Estrogen promotes, progesterone inhibits drug (cocaine) abuse

    An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact...
  8. Brandin

    High dht and dopamine but low gaba?

    Hi I have succesfully increased my dht and lowered my estrogen alot. My stress is also ridicously low but for some reason I cant seem to increase gabaergic effects and feel huge difference when trying for example phenibut once. I think maybe my gaba receptors are very poor from inflammation...
  9. RealNeat

    Peaty Energy Drink (no not Red Bull)

    It's not perfect, but it's one of the best I can find and it even has thiamine (nitrate form) which is not common in energy drinks. It unfortunately has citric acid and agave instead of cane sugar. But it's other components and herbs feel really good and I can regularly depend on it for a mood...
  10. miquelangeles

    GABA, PharmaGABA, topical GABA, liposomal GABA

    Anyone have experience with topical GABA? Also, subjective differences between PharmaGABA and "regular" GABA.
  11. haidut

    AlloP - Liquid Allopregnanolone For Lab/R&D

    Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...
  12. Mito

    The Aging GABAergic System and Its Nutritional Support

    Abstract Aging is associated with a decline in hormones and an associated decline in GABAergic function and calcium and ion current dysregulation. Neurosteroid hormones act as direct calcium channel blockers, or they can act indirectly on calcium channels through their interaction with GABA...
  13. Mauritio

    Fasoracetam upregulates GABA-B receptors and reduces learned helplessness

    Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that. Or people dealing with anxiety, depression...
  14. Mauritio

    Picamilon - a better GABA alternative ?

    Picamilon is a molecular combination of vitamin B3 and GABA , created in russia . It crossed the blood brain barrier and then gets metabolized into B3 and GABA . Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects . It helps to treat parkinsons ,by...
  15. Mauritio

    Autism caused by low allopregnenolone , chinese herb can treat

    This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...
  16. Mauritio

    GABA decreases flouride inuced hypothyroidism; more effective than thyroid hormone

    This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice . This shows what a pro metabolic and protective effect GABA has on the body . So people drinking high fluoride water might want to stack up on GABA for thyroid protection . "Subacute...
  17. R

    Verbascoside (from cistanche) has anxiolytic and hypnotic effects in rat model, potentially due to GABAAR interaction

  18. Hans

    Want Great Boners Without Viagra? Try This Stack Out For Size (pun Intended)

    Just to be clear, this article is about boners (no R rated content though). In this article, I share a potent stack that I've found to work great for powerful and long-lasting erections. Want great boners without Viagra? Try this stack out for size (pun intended) » MENELITE If you do give it a...
  19. BigYellowLemon

    Salt Enhances/potentiates GABA

    The study is a bit specific but it shows in essence that GABA is dependent on salt (sodium chloride) to function, and that the strength of GABA activation in the mammalian body can be controlled to an extent by controlling salt intake. It also is another piece of evidence showing the...
  20. M

    "The GABA System, Defences, And Tissue Renewal"

    The following snippets are taken from Ray's newsletter from 2008. "Protective inhibition is one of the most important principles in biology. Heart disease, cancer, anxiety, allergies, epilepsy, degenerative nerve diseases, endocrine disorders, inappropriate inflammation and shock all involve...