• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.


  1. haidut

    Estrogen promotes, progesterone inhibits drug (cocaine) abuse

    An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact...
  2. Brandin

    High dht and dopamine but low gaba?

    Hi I have succesfully increased my dht and lowered my estrogen alot. My stress is also ridicously low but for some reason I cant seem to increase gabaergic effects and feel huge difference when trying for example phenibut once. I think maybe my gaba receptors are very poor from inflammation...
  3. RealNeat

    Peaty Energy Drink (no not Red Bull)

    It's not perfect, but it's one of the best I can find and it even has thiamine (nitrate form) which is not common in energy drinks. It unfortunately has citric acid and agave instead of cane sugar. But it's other components and herbs feel really good and I can regularly depend on it for a mood...
  4. miquelangeles

    GABA, PharmaGABA, topical GABA, liposomal GABA

    Anyone have experience with topical GABA? Also, subjective differences between PharmaGABA and "regular" GABA.
  5. haidut

    AlloP - Liquid Allopregnanolone For Lab/R&D

    Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...
  6. Mito

    The Aging GABAergic System and Its Nutritional Support

    Abstract Aging is associated with a decline in hormones and an associated decline in GABAergic function and calcium and ion current dysregulation. Neurosteroid hormones act as direct calcium channel blockers, or they can act indirectly on calcium channels through their interaction with GABA...
  7. Mauritio

    Fasoracetam upregulates GABA-B receptors and reduces learned helplessness

    Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that. Or people dealing with anxiety, depression...
  8. Mauritio

    Picamilon - a better GABA alternative ?

    Picamilon is a molecular combination of vitamin B3 and GABA , created in russia . It crossed the blood brain barrier and then gets metabolized into B3 and GABA . Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects . It helps to treat parkinsons ,by...
  9. Mauritio

    Autism caused by low allopregnenolone , chinese herb can treat

    This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...
  10. Mauritio

    GABA decreases flouride inuced hypothyroidism; more effective than thyroid hormone

    This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice . This shows what a pro metabolic and protective effect GABA has on the body . So people drinking high fluoride water might want to stack up on GABA for thyroid protection . "Subacute...
  11. R

    Verbascoside (from cistanche) has anxiolytic and hypnotic effects in rat model, potentially due to GABAAR interaction

  12. Hans

    Want Great Boners Without Viagra? Try This Stack Out For Size (pun Intended)

    Just to be clear, this article is about boners (no R rated content though). In this article, I share a potent stack that I've found to work great for powerful and long-lasting erections. Want great boners without Viagra? Try this stack out for size (pun intended) » MENELITE If you do give it a...
  13. BigYellowLemon

    Salt Enhances/potentiates GABA

    The study is a bit specific but it shows in essence that GABA is dependent on salt (sodium chloride) to function, and that the strength of GABA activation in the mammalian body can be controlled to an extent by controlling salt intake. It also is another piece of evidence showing the...
  14. M

    "The GABA System, Defences, And Tissue Renewal"

    The following snippets are taken from Ray's newsletter from 2008. "Protective inhibition is one of the most important principles in biology. Heart disease, cancer, anxiety, allergies, epilepsy, degenerative nerve diseases, endocrine disorders, inappropriate inflammation and shock all involve...
  15. haidut

    Insects Can Feel Both Acute And Chronic Pain, Can Even Develop Insect-PTSD

    Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of...
  16. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
  17. haidut

    GABA And Glycine Have The Same Effects In The CNS

    I am posting this simply as a pointer for those that suspect they have GABA signalling deficiency. Accodring to this study, instead of supplementing with GABA (which is hard to find in good quality) supplementing with glycine may have the same effects/benefits. Peat spoke about the similarity of...
  18. haidut

    Intrusive / Unwanted Thoughts Due To Low GABA Signalling

    Peat has mentioned GABA quite a few times in his articles and its role as the chief inhibitory signal in the body, protecting both brain cells and peripheral tissues/organs from excitotoxicity caused by PUFA, glutamate, estrogen, stress, etc. But the role of GABA is especially prominent in the...
  19. haidut

    Loneliness Increases Alcohol Tolerance, May Explain "addiction"

    I posted several studies in the past about the connection between stress hormones and "addiction", especially alcohol. This new study adds more evidence to that link and now also draws serotonin in the picture. Apparently, social creatures are much more sensitive to inebriation effects of...
  20. P

    Evidence For A GABAergic System In Rodent And Human Testis: Local GABA Production And GABA Receptors

    Like dopamine and serotonin, gaba is not only active in the brain , it has peripheral functions too. Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. - PubMed - NCBI Abstract The major neurotransmitter of the central nervous system...