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I had posted around 2 years ago how eating boiled shitake mushrooms brought about the worst Belly Button infection of my life (Attached photo will give you an idea).
Its like a semi hard thing slowly trying to come out from my navel, and once it does it bursts out like a boil and carries pus...
I found this very interesting thread that claim microdosing stimulants like amphetamine can long-term sensitize dopamine receptors
View: https://www.reddit.com/r/Stims/comments/3mbp3n/be_very_careful_with_low_doses_of_stimulants/
”In rats, dopaminergic supersensitivity from low-dosage...
I struggle with anxiety, ADD, OCD and rumination/overthinking. My cortisol, ACTH and prolactin is elevated (prolactin low after D2-agonist treatment).
I think my main problems are low dopamine and low GABA. Which drugs and supplements do you recommend?
Vitamin B6 is perhaps one of the most underrated B vitamins. While it attracted a lot of interest in the 1960s and 1970s as a potential natural treatment to raise dopamine and/or lower prolactin, subsequent "well-controlled" studies claimed that it was not effective. However, the fact remains...
I've seen some people concerned with GABA rebound effects from l-theanine due to effects on increasing GABA. Theanine is commonly mentioned as a gaba agonist.
1. Does it actually have significant effects on GABA that would lead to rebound?
2. Would a daily gram amounts be safe for potential...
After experimenting with glycine last night (1g in OJ) I've heard a LOUD screaming in my ear while I was sleeping. Woke me up and scared the sh*tout of me xd
Knew it was "in my head" because my extremely alert dog was sleeping.
I also woke up with extremely dry mouth, grogginess and fatigue...
An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact...
Hi I have succesfully increased my dht and lowered my estrogen alot. My stress is also ridicously low but for some reason I cant seem to increase gabaergic effects and feel huge difference when trying for example phenibut once.
I think maybe my gaba receptors are very poor from inflammation...
It's not perfect, but it's one of the best I can find and it even has thiamine (nitrate form) which is not common in energy drinks.
It unfortunately has citric acid and agave instead of cane sugar. But it's other components and herbs feel really good and I can regularly depend on it for a mood...
Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...
Abstract
Aging is associated with a decline in hormones and an associated decline in GABAergic function and calcium and ion current dysregulation. Neurosteroid hormones act as direct calcium channel blockers, or they can act indirectly on calcium channels through their interaction with GABA...
Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that.
Or people dealing with anxiety, depression...
Picamilon is a molecular combination of vitamin B3 and GABA , created in russia .
It crossed the blood brain barrier and then gets metabolized into B3 and GABA .
Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects .
It helps to treat parkinsons ,by...
This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice .
First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...
This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice .
This shows what a pro metabolic and protective effect GABA has on the body .
So people drinking high fluoride water might want to stack up on GABA for thyroid protection .
"Subacute...
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The study is a bit specific but it shows in essence that GABA is dependent on salt (sodium chloride) to function, and that the strength of GABA activation in the mammalian body can be controlled to an extent by controlling salt intake. It also is another piece of evidence showing the...
The following snippets are taken from Ray's newsletter from 2008.
"Protective inhibition is one of the most important principles in biology. Heart disease, cancer, anxiety, allergies, epilepsy, degenerative nerve diseases, endocrine disorders, inappropriate inflammation and shock all involve...