gaba

Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...

Abstract Aging is associated with a decline in hormones and an associated decline in GABAergic function and calcium and ion current dysregulation. Neurosteroid hormones act as direct calcium channel blockers, or they can act indirectly on calcium channels through their interaction with GABA...

Fasoracetam might be especially interesting for people that don't react well to the other racetams and stimulants in generel. I've found that phenylpiracetam can make me a bit irritable, but stacking it with something GABAergic alleviated that. Or people dealing with anxiety, depression...

Picamilon is a molecular combination of vitamin B3 and GABA , created in russia . It crossed the blood brain barrier and then gets metabolized into B3 and GABA . Thus it was shown to have brain protective , mood enhancing, and lactate lowering effects . It helps to treat parkinsons ,by...

This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...

This study shows that GABA increases thyroid hormones that were downregulsted from fluoride ingestion in mice . This shows what a pro metabolic and protective effect GABA has on the body . So people drinking high fluoride water might want to stack up on GABA for thyroid protection . "Subacute...

https://pubmed.ncbi.nlm.nih.gov/28884085/

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The study is a bit specific but it shows in essence that GABA is dependent on salt (sodium chloride) to function, and that the strength of GABA activation in the mammalian body can be controlled to an extent by controlling salt intake. It also is another piece of evidence showing the...

The following snippets are taken from Ray's newsletter from 2008. "Protective inhibition is one of the most important principles in biology. Heart disease, cancer, anxiety, allergies, epilepsy, degenerative nerve diseases, endocrine disorders, inappropriate inflammation and shock all involve...

Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of...

The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...

I am posting this simply as a pointer for those that suspect they have GABA signalling deficiency. Accodring to this study, instead of supplementing with GABA (which is hard to find in good quality) supplementing with glycine may have the same effects/benefits. Peat spoke about the similarity of...

Peat has mentioned GABA quite a few times in his articles and its role as the chief inhibitory signal in the body, protecting both brain cells and peripheral tissues/organs from excitotoxicity caused by PUFA, glutamate, estrogen, stress, etc. But the role of GABA is especially prominent in the...

I posted several studies in the past about the connection between stress hormones and "addiction", especially alcohol. This new study adds more evidence to that link and now also draws serotonin in the picture. Apparently, social creatures are much more sensitive to inebriation effects of...

Like dopamine and serotonin, gaba is not only active in the brain , it has peripheral functions too. Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. - PubMed - NCBI Abstract The major neurotransmitter of the central nervous system...

Insulin Neuroprotection and the Mechanisms Insulin, Neuroprotection, GABA, Glucose, Glycogen, Ischemia, Glutamate Introduction Insulin is the only endocrinology hormone to decrease blood glucose. In addition, insulin serves as a growth factor, modulating mitogenesis, growth, and...

It has been shown that progesterone rapidly metabolizes into more saturated metabolites such as 5α-Dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (also known as allopregnanolone or Allo). The enzyme 5-AR is the one responsible for the saturation, just as it is responsible for the...

The study was really on alcohol consumption what affects it. It has been known since the 1960s that people drink more when under stress but to this day mainstream medicine denies that there is a causative link between stress and substance abuse. I posted a few studies showing that "addicts" have...

I just posted a thread about androsterone and its potent anti-depressant effects: Androsterone - An Andidepressant Neurosteroid Just like allopregannolone (ALLO), androsterone is 5-AR derived neurosteroid, and just like allopreganolone androsterone is a very potent GABA agonist (even more...