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chronic

  1. haidut

    Lowering adrenaline as effective as opioids for severe/chronic pain

    Most of my readers know about the raging opioid abuse epidemic in Western countries. What most people do not know is that the bulk of the epidemic is not in usage of illegal opioids such as fentanyl, but in legally prescribed opioids such as methadone, oxycontin, and even morphine. There are...
    • haidut
    • Thread
    • addiction adrenaline chronic clonidine opioid pain rat park stress
    • Replies: 5
    • Forum: Scientific Studies
  2. haidut

    DHT as anti-inflammatory as cortisol, but without the side effects

    As most of my readers know, glucocorticoids (synthetic or bioidentical) are widely used clinically and there is hardly a chronic conditions for which they are not prescribed even if only for managing brief "acute exacerbations". Despite mainstream medicine doing everything it can to conceal the...
    • haidut
    • Thread
    • androgen chronic cortisol dht gastritis glucocorticoid inflammation
    • Replies: 5
    • Forum: Scientific Studies
  3. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
    • haidut
    • Thread
    • cancer cancerization chronic endotoxin inflammation low-grade lps tlr4
    • Replies: 2
    • Forum: Scientific Studies
  4. haidut

    Exercise causes (and worsens) arterial calcification

    A great new study sent to me by one of my readers. It will more than likely cause a lot of controversy, despite its findings having a very simple explanation. Namely, chronic exercise increases baseline cortisol and over time, cortisol (acting through the aldosterone/mineralocorticoid receptor)...
    • haidut
    • Thread
    • aldosterone calcification chronic cortisol exercise soft-tissue calcification stress
    • Replies: 28
    • Forum: Scientific Studies
  5. haidut

    Both "long" COVID-19 and CFS are likely caused by hypometabolism

    A good study that examines the remarkable parallels between the so-called "long" COVID-19 (i.e. chronic display of symptoms associated with COVID-19) and the (in)famous chronic fatigue syndrome (CFS). Namely, increases inflammation, excessive glycolysis, suppressed mitochondrial function and...
    • haidut
    • Thread
    • atp cfs chronic covid-19 hypometabolism infection inflammation virus
    • Replies: 153
    • Forum: Scientific Studies
  6. haidut

    Many people may suffer from chronic serotonin syndrome

    A very interesting article, which calls out the widespread usage of serotonergic drugs (usually SSRI), and argues that their widespread use may have created an "epidemic" of a chronic, milder version of the (in)famous serotonin syndrome (SS). Currently, mainstream medicine does not recognize...
    • haidut
    • Thread
    • 5-ht acute chronic common serotonin serotonin syndrome ssri
    • Replies: 65
    • Forum: Scientific Studies
  7. haidut

    Ear wax testing as a reliable method for measuring long-term steroid levels

    Many of my readers already know about the unreliability of using steroid blood tests as diagnostic methods, except in cases where the values are so extreme that are unlikely to be temporary fluctuations. Saliva tests for steroids are even less reliable, even though combining both saliva and...
    • haidut
    • Thread
    • average blood chronic cortisol ear wax hair saliva steroid
    • Replies: 3
    • Forum: Scientific Studies
  8. haidut

    Insects Can Feel Both Acute And Chronic Pain, Can Even Develop Insect-PTSD

    Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of...
    • haidut
    • Thread
    • acute animals chronic feel gaba glycine inhibitory insects neuropathic pain ptsd
    • Replies: 4
    • Forum: Scientific Studies
  9. haidut

    Vast Majority (90%) Of Depression Cases Are Caused By Stress

    In case anybody continues to doubt the stress-depression connection and/or their doctor tries to convince them their depression is due to genetic predisposition, below is an eye-opening statement from the mighty WebMD - the mouthpiece of mainstream medicine. As the article states, about 10% of...
    • haidut
    • Thread
    • cause chronic depression environment mental disorder mental illness stress trigger
    • Replies: 2
    • Forum: Scientific Studies
  10. haidut

    Damaged Mitochondria And Endotoxin (LPS) Drive Chronic Inflammation

    Chronic, low-grade inflammation has now been recognized as the main cause behind a number of chronic degenerative conditions including CVD, diabetes, cancer, Alzheimer, Parkinson, etc. Mainstream medicine claims that the cause of this chronic low-grade inflammatory reaction is unknown, despite...
    • haidut
    • Thread
    • choline chronic damage endotoxin inflammation lps mitochondria mitophagy stress tlr4
    • Replies: 5
    • Forum: Scientific Studies
  11. haidut

    High Cortisol And Low Testosterone Likely Drive PTSD

    As the article below states, 20%+ of service members come back with PTSD. It is a devastating mental condition that makes patients not only unable to participate meaningfully in society but often drives them to violent and homicidal/suicidal behavior. Given the roles of cortisol and serotonin in...
    • haidut
    • Thread
    • acute cause chronic cortisol drive elevated high ptsd stress trauma
    • Replies: 4
    • Forum: Scientific Studies
  12. haidut

    Cheating Is Driven By Cortisol, Not Testosterone

    The topic of macho behavior and its apparent mediator testosterone has been studies every since steroids were discovered. The mainstream dogma states that high testosterone drives cheating behavior (especially of males) as some sort of dominance-asserting behavior of genetically superior...
    • haidut
    • Thread
    • cause cheating chronic cortisol glucocorticoid rationale reason stress
    • Replies: 37
    • Forum: Scientific Studies
  13. haidut

    Cortisol (stress) Directly Causes Depression

    I have posted quite a few threads/posts on the role of stress as perhaps the main cause of depression and other mental disorders. Officially, psychiatry claims that no environmental factor is known to be a direct cause of depression and that depression is a “complex” mix of genetic...
    • haidut
    • Thread
    • cause chronic corticosterone cortisol csd cums depression glucocorticoid ketamine serotonin stress
    • Replies: 26
    • Forum: Scientific Studies
  14. haidut

    Stress As The Underlying Cause Behind ALL Chronic Diseases

    One of the more controversial of Ray's statements is that chronic stress is the underlying cause of many/most chronic conditions, especially autoimmune ones. In several of his articles he describes the role tissue damage under the influence of cortisol and estrogen play in creating an immune...
    • haidut
    • Thread
    • activation autoimmune chronic cortisol damage debris disease dna estrogen immune system inflammation mitochondria morphostasis stress stress response systemic tlr9
    • Replies: 22
    • Forum: Scientific Studies
  15. haidut

    High Norepinephrine Can Be Used To Diagnose Fibromyalgia

    Fibromyalgia is one of the "mysterious" spectrum disorders, which baffles doctors. There is no structural abnormality in muscle tissue and as a result many patients are treated as if the condition is a psychiatric one. It is known to be greatly exacerbated by stress, which is a convenient excuse...
    • haidut
    • Thread
    • biomarker causative chronic diagnosis fibromyalgia noradrenaline norepinephrine stress
    • Replies: 18
    • Forum: Scientific Studies
  16. haidut

    Pregnenolone Relieves Chronic Low Back Pain (human Study)

    After failing to find any effective treatments for the many ills that plague veterans, doctors are finally turning to older remedies successfully used back in the first half of the 20th century. Pregnenolone is one such remedy and I have been seeing more and more studies and ongoing trials with...
    • haidut
    • Thread
    • anesthetic back pain chronic neurosteroid pregnenolone quality of life veteran
    • Replies: 12
    • Forum: Scientific Studies
  17. haidut

    Workplace Stress Is Literally Killing People; Mass Lawsuits Are Imminent

    It is good to see that even business school people - that bastion of workaholism - are finally opening their eyes to what the modern workplace is doing to the health of the populace. Even though I think this realization will fall on deaf years when it comes to executives changing the work...
    • haidut
    • Thread
    • cancer cause chronic cvd diabetes disease employment killing people stress work workplace
    • Replies: 91
    • Forum: Scientific Studies
  18. haidut

    Higher Fat Diets And Fat Emulsification Increase Endotoxin (in Obese Males)

    High dietary fat is one of the primary factors for increased endotoxin load, especially if the fat is PUFA. This is probably one of the main reasons Peat prefers lower fat diets. However, most of the studies on the fat-endotoxin link so far have been on animal models. This new human study...
    • haidut
    • Thread
    • absorption chronic diet disease emulsification endotoxin high-fat increase obesity
    • Replies: 12
    • Forum: Scientific Studies
  19. haidut

    Chronic Stress During Pregnancy Accelerates Fetal Aging And Harms Its Health

    Allopathic medicine still denies that maternal stress during pregnancy affects the child's long term health. If anything, they say that the fetus may experience a slightly increased risk of infection during pregnancy but that risk goes back normal as soon as the baby is born. The main argument...
    • haidut
    • Thread
    • aging chronic cortisol crh fetus health pregnancy pregnenolone premature stress
    • Replies: 5
    • Forum: Scientific Studies
  20. haidut

    Safety Of Long-term Use Of DMSO As A Solvent

    I wanted to post this even though it won't change the mind of DMSO opponents. The topic of DMSO safety has come up multiple times among scientists using it as a solvent for delivery of chemicals in vivo studies and so I did some digging and found some interesting data point. First, DMSO used in...
    • haidut
    • Thread
    • acetone animals chronic dmso ethanol liver peg pg protective safety solvent toxicity
    • Replies: 136
    • Forum: Scientific Studies
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