pain

  1. S

    Acetaminophen (APAP) increases risk taking behaviour

    https://pubmed.ncbi.nlm.nih.gov/32888031/ Acetaminophen, an analgesic and antipyretic available over-the-counter and used in over 600 medicines, is one of the most consumed drugs in the USA. Recent research has suggested that acetaminophen's effects extend to the blunting of negative as well as...
  2. ScurveDream

    Chronic Pain Relieved Greatly By Benadryl/diphenhydramine & Nightmares (story-time)?

    I'm including details here that I've never told anyone/written that much about to my knowledge, but all of it does not need to be read if you're not used to my extremely long, often (arguably) strange posts I make here. So I was going to post here about it (the pain), but figured it would be a...
  3. JazTee

    Ehlers-Danlos Syndrome Help?

    Hi all, I recently posted a thread here: (Feeling Terrible at 22) where I basically listed all my symptoms and recieved some amazing advice for my metabolism, overall dietary health etc. I suggest reading this post first to get an insight into my lifestyle and health. (TL-DR; I basically...
  4. haidut

    Pregnenolone Safe And Effective In Big Human Trial For Back Pain

    About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. Pregnenolone Relieves Chronic Low Back Pain (human Study) At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly...
  5. haidut

    Fish Feel Pain Just Like Other Animals And Humans

    Yet another piece of evidence that there is no such thing as a "lower animal" and pretty much anything with consciousness experiences pain much the same way we do. Yet despite these advances in our understanding of how similar we are to any other living creature, we still have surgeons...
  6. haidut

    Insects Can Feel Both Acute And Chronic Pain, Can Even Develop Insect-PTSD

    Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of...
  7. haidut

    Fibromyalgia May Be Simply A Sign Of Insulin Resistance

    As many of your have seen on TV, there is currently a boom in ads for drigs to treat fibromyalgia. This condition is yet another one of mysterious origins, at least according to mainstream medicine. The treatment consists mainly of GABA agonists like Lyrica but the official version is (of...
  8. ecstatichamster

    LPS (endotoxins) Kills Pain

    https://www.sciencedirect.com/science/article/pii/0006899394919089 Abstract Activation of the immune system in response to either infection or lipopolysaccharide (LPS) produces neurophysiological, neuroendocrine and behavioral changes. Some of the physiological consequences of LPS are mediated...
  9. P

    Effect Of Vitamin D Supplementation On Pain: A Systematic Review And Meta-analysis

    Effect of Vitamin D Supplementation on Pain: A Systematic Review and Meta-analysis. - PubMed - NCBI CONCLUSION: A significantly greater mean decrease in pain score (primary outcome) was observed with vitamin D supplementation compared with placebo in people with chronic pain. These results...
  10. Giraffe

    Analgesic Effect Of Methylene Blue

    I came accross an article written by Paul Ehrlich and Arthur Leppmann called "Über schmerzstillende Wirkung des Methylenblau." published in 1890 in the Deutsche Medizinische Wochenschrift. This was a couple of years before Aspirin came on the market. The researchers tested methylene blue on...
  11. haidut

    Emotional Response To Pain Is Driven By Serotonin And Prostaglandins

    I posted previously on how serotonin is required for the formation of traumatic memories. This process plays a major role in disorders like depression, PTSD, chronic anxiety and even schizophrenia. Serotonin Is Involved In The Formation Of Traumatic Memories This study shows that the activation...
  12. L

    Complex Regional Pain Syndrome

    Anyone know anything about this condition and how to treat using Ray Peat friendly suggestions? I do not have enough comprehension or knowledge to attempt to help her but I feel for her and she is a bit panicked. A friend has recently been diagnosed with this condition and she is suffering. MD...
  13. haidut

    Theanine As A Novel Painkiller

    The placebo effect has been confirmed in many studies, and there have even been calls to change its name since the current one is at best a misnomer - i.e. we seem to have a much more fundamental and physical connection with our environment than the presence or lack of chemicals/drugs can...
  14. haidut

    Opioids Increase Pain Through Endotoxin Receptor, Minocycline Reverses The Effect

    Most people here know Peat's opinion about opioids due to their effects on histamine, estrogen, and promoting tissue growth. A few weeks ago I posted a link in regards to the so-called "endotoxin receptor" known as TLR4, and how opioids are the main class of substances that activate that...
  15. Pointless

    T3 And Neuropathic Pain

    I bought some T3 and T4 from USA Peptide in separate bottles. I take the T3 3 times a day, and with the last dose, I take twice as much T4 along with it. They are both in 200 mcg/mL, which would be an approximate dose of 10 mcg/drop. I try to eat it with food to prolong the spike in...
  16. haidut

    Itching May Be Driven By Serotonin

    I have always wondered about this phenomenon and why it is that people with chronic conditions or depression seem to have a problem with excessive itching. It turns out that itching is closely related to pain and as such the release of serotonin. I already posted about the relationship between...
  17. S

    Pain Causes Relapse In A Model Of Multiple Sclerosis

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model
  18. haidut

    Babies Feel Pain Just Like Adults

    Ray is often critical of the tendency of modern science to consider living organisms in a hierarchy of "consciousness", with organisms lower in the hierarchy considered to be "less than fully alive" and certainly not able to experience the full gamut of what humans are capable of. Here is a...
  19. haidut

    Why Ray Peat May Be Advising Against (strong) Spices

    Ray has written on the topic of de-ennervation and how it negatively affects the tissues where nerves die off or have reduced communication efficiency. He wrote that some spices, especially capsaicin, are known to cause de-ennervation and he tries to avoid those. This recent study seems to...
  20. R

    Aspirin - Causing "pain"!

    Yes, aspirin seems to reveal some kind of pain. It's not actually a problem, no severe pain, but I wonder what it's all about. I have mentioned in another thread that I have problems on the left side of my body, and now when I take aspirin I "feel" stuff going on in my hip, shoulder and along...
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