glycine

  1. haidut

    Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

    A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also...
  2. haidut

    Glycine has a universal anti-viral effect

    While the study below does not go as far as to say that glycine would be an appropriate intervention for the current COVID-19 pandemic, it does describe an anti-viral mechanism for glycine that is (at least in theory) applicable to ALL viruses. Namely, glycine prevents for formation of capsids...
  3. Lokzo

    Glycine Reduces NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome - 2020

    Amino acids alleviate liver disease Glycine is known to be reduced in patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), diseases with no approved treatments. Rom et al. found that glycine biosynthetic genes showed reduced expression in humans and...
  4. Ras

    Glycine Ameliorates NAFLD By Modulating FAO, Glutathione Synthesis, And The Gut Microbiome

    Altered the title to make it fit. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome Full text ABSTRACT Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic...
  5. explosionlord

    Aspirin + K2 + Glycine Poor Reaction; Anybody Else?

    Hey folks, This morning I took a mixture of ~3g glycine powder, 90 ug K2 (MK7), and 650 mg typical otc aspirin. About an hour later, my eyes became bloodshot, followed by lightheadedness and reddened skin. Probably a long shot, but has anyone tried this combo and had anything near these...
  6. haidut

    Aging Likely Caused By Decreased Respiration / Metabolism, Not Genetic Mutations

    It looks like after a century of utter idiotism in biology and medicine, those two disciplines may finally be getting on the right course. Despite the fact that the "rate of living" theory is still the dominant theory of aging in the halls of academia, a new generation of scientists is emerging...
  7. haidut

    Insects Can Feel Both Acute And Chronic Pain, Can Even Develop Insect-PTSD

    Probably not many forum users know it, but to this day surgery on babies or other painful procedures is often performed without anesthesia. The rationale for this horrific torture is that the nervous system of babies is not developed yet, so they don't feel pain. It takes a special kind of...
  8. Captain_Coconut

    Chamomile Boosts Biosynthesis Of Glycine

    A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion http://www.wipm.cas.cn/jgsz/yjdw/cigongzhenyingyong/shengwuyixue/yanjiuchengguo/201204/W020120525419285123515.pdf According to this study: two weeks of daily chamomile tea...
  9. haidut

    Cosmic Radiation Can Create Life-building Blocks From Ammonia & CO2

    Peat mentioned this in a few of his articles and the process of formation of basic amino acids from simpler chemicals is well-known. But up until now the "trigger" or "spark" of this process was not known. The study below shows that low-energy electrons from cosmic radiation can serve as that...
  10. haidut

    Glycine May Treat Lung, Brain And Other Cancers

    Lung and brain (glioblastoma) cancer are among the deadliest. The 5 year survival rates of both are below 20%. So, any progress in treating those cancer types would be a huge leap forward for oncology. As the study says, there is a growing realization that cancers are highly metabolically...
  11. P

    Glycine Enhances Expression Of Adiponectin And IL-10 In 3T3-L1 Adipocytes Without Affecting Adipogen

    https://www.ncbi.nlm.nih.gov/pubmed/29356901 Amino Acids. 2018 Jan 22. doi: 10.1007/s00726-018-2537-3. [Epub ahead of print] Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis. Chen J1, Ma X1, Yang Y1, Dai Z1, Wu Z2,3, Wu G1,4...
  12. haidut

    GABA And Glycine Have The Same Effects In The CNS

    I am posting this simply as a pointer for those that suspect they have GABA signalling deficiency. Accodring to this study, instead of supplementing with GABA (which is hard to find in good quality) supplementing with glycine may have the same effects/benefits. Peat spoke about the similarity of...
  13. haidut

    Glycine Is Directly Anabolic AND Anticatabolic For The Muscle

    I posted a few interesting studies about glycine in the past. Among the interesting properties are lowering cortisol, increasing DHT synthesis, improving insulin sensitivity, and serving as a biomarker of stress. Glycine Powerfully Lowers Cortisol Glycine Strongly Upregulates 5-alpha Reductase...
  14. haidut

    Glycine Can Be Abundant (and Cheap) Source Of Electricity

    This is not a biochemical study, so it may not be of much value to most forum users. However, I thought I'd post it anyways due to the curious properties of glycine, which Peat has written about for a long time and which continue to mesmerize and confuse the medical profession. Peat wrote a few...
  15. haidut

    Glycine May Treat Hearing Issues Caused By NSAID (aspirin?)

    It is common knowledge that several NASID drugs, including aspirin, cause hearing issues at higher doses. This new research found that the mechanism of action is by competition with chloride ions for activation of the hearing protein called prestin. This suggests a possible method of blocking...
  16. haidut

    Cheetahs In Captivity Die Early Due To High PUFA / Low Glycine Diet

    I know cheetahs are not the most applicable model to humans but the dramatic decrease in life expectancy for captive cheetahs caught my eye, as well as the fact that the two factor (high PUFA, low glycine) were the only metabolic abnormalities identified so far. I think the glycine deficiency is...
  17. haidut

    C. Difficile Gut Infection Or Even IBD May Be Due To Low Vitamin D Or PPI Drugs

    As the study says, the direct cause is high intestinal levels of calcium but as the study also says these are usually due to poor calcium absorption. And unless a person has IBD (which is rare) the low vitamin D status or PPI drug (GERD) use stand out as the most likely causes, even more so...
  18. haidut

    Aspirin (but Not Other NSAID) Treats Barrett’s Esophagus And Possibly GERD

    The good news for aspirin just keep on coming. I posted a few studied in the past about GERD and its progressions Barrett’s esophagus, and esophageal cancer being caused by inflammation and not stomach acid. As such, PPI drugs are probably useless for treating and preventing GERD (since they...
  19. haidut

    Glycine May Protect From Heart Disease In Women

    The study looked at carriers of a specific variant of the gene CPS1 and the control this gene exerts over specific metabolites. Carriers of this gene variant had significantly increased glycine levels in the blood and lower levels of urea cycle metabolites, especially citrulline (which is a...
  20. Amazoniac

    Swore By Their Favorite Plush Toy: Supplemental Gelatin Might Require Extra Vitamin B12

    ..and can exacerbate a deficiency, especially in large amounts. Toxicity of Glycine for Vitamin B12-Deficient Chicks.† <- Crosses like this are scary. "Twenty-eight day-old White Leghorn chicks which had been fed the vito B12-deficient diet shown in Table I from the day of hatching were used...
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