Eugenol increases sex hormones lowers COX2 and protects liver in diabetic model

[Mauritio]

Here they looked at what eugenol did to a rat model of diabetes.
They found that it lowered Glucose , triglycerides and LDL-cholsterol, which decreased especially strongly from 50 to 6 in the highest eugenol group. Just for reference the control groups level was 30, so it lowered below their level.

It increased Testosterone, progesterone and estrogen levels compared to the diabetic group. Not sure why estrogen was increased, but compared to the control group it wasn't really increased, rather it restored the levels of diabetic mice to that of the control group. With one exception, it increased progesterone even slightly above the control group. It migth also be relevant that those were femalre rats.

It also increased anti-oxidant enzymes and lowered malonaldehyde and liver enzyme levels.

The dosage was 12 or 24mg/kg in rats, which translates to 150 / 300mg in humans. the 150mg dose was slightly superior in most values they looked at. I'm starting to think that a dose of 100-200mg of eugenol is optimal.

- https://assets.researchsquare.com/f...-80f9-4a9d-a28e-2b3962115a1b.pdf?c=1662158168

 

[ddjd]

Eugenol is in sage from what I remember. Sage has such an array of healing benefits

Phytoestrogen is having an anti-estrogenic effect.....Sage (Salvia officinalis) tea

Sage also has antimicrobial effects, which can neutralize microbes that promote dental plaque. In one study, a sage-based mouthwash was shown to effectively kill the Streptococcus mutans bacteria, which is notorious for causing dental cavities https://pubmed.ncbi.nlm.nih.gov/26668706/...

raypeatforum.com

 

[Mauritio]

Eugenol is in sage from what I remember. Sage has such an array of healing benefits

Phytoestrogen is having an anti-estrogenic effect.....Sage (Salvia officinalis) tea

Sage also has antimicrobial effects, which can neutralize microbes that promote dental plaque. In one study, a sage-based mouthwash was shown to effectively kill the Streptococcus mutans bacteria, which is notorious for causing dental cavities https://pubmed.ncbi.nlm.nih.gov/26668706/...

raypeatforum.com

eugenol is also in clove oil, as matter of fact ,it is its main component.

 

[sunny]

Talking about eugenol

Aspirin / eugenol can remove lipofuscin from cells

One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...

raypeatforum.com

 

[David PS]

Talking about eugenol

Aspirin / eugenol can remove lipofuscin from cells

One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...

raypeatforum.com

The lipofuscin that I am concerned about is in my internal organs. Lipofuscin is the reason that I add 2-3 drops into my coffee. @Mauritio - It is good to learn that this is a good dose. Thanks

 

[laleto12]

Don’t let the guy from twitter who overdosed on Eugonel see this

 

[Highserotonin90]

@David PS 2-3 drops of clove essential oil? Can you estimate how many mg d of Eugenol are?

 

[David PS]

@David PS 2-3 drops of clove essential oil? Can you estimate how many mg d of Eugenol are?

This was done yesterday in this thread.

 

[baron]

Don’t let the guy from twitter who overdosed on Eugonel see this

I don't think he overdosed, just a regular dose and aspirin caused alot of PUFA to be released from fat stores and started collecting in his foot.

 

[Mossy]

The lipofuscin that I am concerned about is in my internal organs. Lipofuscin is the reason that I add 2-3 drops into my coffee. @Mauritio - It is good to learn that this is a good dose. Thanks

Have you been doing this for a while? I ask because I'm curious about the response of your body to this.

 

[David PS]

Have you been doing this for a while? I ask because I'm curious about the response of your body to this.

I have been adding eugenol to my first cup of coffee in the morning since early March 2023 when Haidut started the thread "Aspirin / eugenol can remove lipofuscin from cells". I did not expect to subjectively feel any response and I did not experience anything. Note - I have been keeping my PUFA intake low and I have been adding adding aspirin to my coffee (with vitamin K) for years. I am just trying to 'wring' the last bit of lipofuscin out of my body.

This older thread "Clove Oil (eugenol) Inhibited 97.3% Lipid Peroxidation And Decreases TGF‐β1 Expression" suggested that eugenol may be 5 times more potent than aspirin.

I have been aiming to add only 1 drop into my coffee but I seem to end up adding 2-3 drops. And, that is not a bad thing.

 

[Mossy]

I have been adding eugenol to my first cup of coffee in the morning since early March 2023 when Haidut started the thread "Aspirin / eugenol can remove lipofuscin from cells". I did not expect to subjectively feel any response and I did not experience anything. Note - I have been keeping my PUFA intake low and I have been adding adding aspirin to my coffee (with vitamin K) for years. I am just trying to 'wring' the last bit of lipofuscin out of my body.

This older thread "Clove Oil (eugenol) Inhibited 97.3% Lipid Peroxidation And Decreases TGF‐β1 Expression" suggested that eugenol may be 5 times more potent than aspirin.

I have been aiming to add only 1 drop into my coffee but I seem to end up adding 2-3 drops. And, that is not a bad thing.

Good to know nothing negative after many months. I had tried a drop of clove oil on my tooth brush but it was too much. I think 1-3 drops with food would go down easier.

I did see that thread, which was my inspiration for wanting to supplement it, with aspirin—just as you are doing.

 

[Elie]

I have been adding eugenol to my first cup of coffee in the morning since early March 2023 when Haidut started the thread "Aspirin / eugenol can remove lipofuscin from cells". I did not expect to subjectively feel any response and I did not experience anything. Note - I have been keeping my PUFA intake low and I have been adding adding aspirin to my coffee (with vitamin K) for years. I am just trying to 'wring' the last bit of lipofuscin out of my body.

This older thread "Clove Oil (eugenol) Inhibited 97.3% Lipid Peroxidation And Decreases TGF‐β1 Expression" suggested that eugenol may be 5 times more potent than aspirin.

I have been aiming to add only 1 drop into my coffee but I seem to end up adding 2-3 drops. And, that is not a bad thing.

How does clove oil affect the taste of coffee?

 

[David PS]

How does clove oil affect the taste of coffee?

It was noticeable when I started but now I do not even notice the taste. Now it is just normal. It was never a bad taste.

 

[Elie]

It was noticeable when I started but now I do not even notice the taste. Now it is just normal. It was never a bad taste.

does the bottle the concentration of Eugenol?

 

[David PS]

does the bottle the concentration of Eugenol?

Amazon product
View: https://www.amazon.com/gp/product/B07PC64LMX/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&th=1

 

[Elie]

View attachment 55570Amazon product
View: https://www.amazon.com/gp/product/B07PC64LMX/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&th=1

 

[Elie]

thank you

 

[Mauritio]

I don't think he overdosed, just a regular dose and aspirin caused alot of PUFA to be released from fat stores and started collecting in his foot.

WTF how does that manifest ?

 

[NewACC]

Here they looked at what eugenol did to a rat model of diabetes.
They found that it lowered Glucose , triglycerides and LDL-cholsterol, which decreased especially strongly from 50 to 6 in the highest eugenol group. Just for reference the control groups level was 30, so it lowered below their level.

It increased Testosterone, progesterone and estrogen levels compared to the diabetic group. Not sure why estrogen was increased, but compared to the control group it wasn't really increased, rather it restored the levels of diabetic mice to that of the control group. With one exception, it increased progesterone even slightly above the control group. It migth also be relevant that those were femalre rats.

It also increased anti-oxidant enzymes and lowered malonaldehyde and liver enzyme levels.

The dosage was 12 or 24mg/kg in rats, which translates to 150 / 300mg in humans. the 150mg dose was slightly superior in most values they looked at. I'm starting to think that a dose of 100-200mg of eugenol is optimal.

- https://assets.researchsquare.com/f...-80f9-4a9d-a28e-2b3962115a1b.pdf?c=1662158168

@haidut What is the best way to consume eugenol and clove oil without completely numbing your mouth?