KyleKingsly
Member
- Joined
- Feb 15, 2018
- Messages
- 97
I'm fairly certain I have pretty bad insulin resistance based on my high fasting blood sugars and A1C (I have pre-diabetes that I'm pretty concerned about), along with the fact that it's incredibly difficult for me to get to the point of feeling satisfied after a meal. I'm pretty sure there's some degree of fatty liver going on too given that I've gained a ton of weight (50+ lbs) in the past year and feel like my ability to store glycogen is highly compromised because I keep waking up after 6 or less hours of sleep feeling shaky and hungry.
I think my insulin resistance is the most important issue for me to fix right now because it's really destroying my ability to sleep, focus, and eat in a healthy way. So I've been doing a ton of research on the best ways to improve insulin sensitivity and one very promising suggestion I've found is berberine. It's pretty similar to metformin which I know is highly looked down upon here and is a "metabolic toxin" according to @haidut so I am somewhat hesitant about it.
It apparently inhibits mitochondrial 1 complex, lowers the NAD/NADH ratio, and inhibits lactate dehydrogenase and pyruvate dehydrogenase. I don't really understand the precise science behind all of that beyond the fact that all of those things seem to be pretty important for metabolism. However, I'm wondering if I can avoid some of the damage berberine might cause by using things like CoQ10, Energin, and Pansterone (among other things). Also, Berberine apparently protects against metformin induced lactic acidosis, so I'm guessing it's not nearly as bad as metformin in the lactic acid department. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
On the other band, berberine is supposed to be really good at blocking the creation of new fat, nutrient partitioning, meaning that glucose gets into the muscles and not stored as fat, reversing fatty liver, improving gut health, and strongly boosting insulin sensitivity. It seems like it could really benefit me so I'd really like to give it a try if y'all think it's safe.
If not, what are the strongest things you would suggest for boosting insulin sensitivity? I've seen aspirin and niacinamide mentioned here a lot but I've also heard that they can hinder fat loss which I don't think would be good for my fatty liver or my overall health. Suggestions for strong things that can help me eat less while feeling more satisfied and most importantly sleep through the night would be greatly appreciated. I can only afford to buy one supplement for around $35 or so right now so I'm really trying to get the most value for my money.
Thanks so much! Any and all advice is greatly appreciated!
I think my insulin resistance is the most important issue for me to fix right now because it's really destroying my ability to sleep, focus, and eat in a healthy way. So I've been doing a ton of research on the best ways to improve insulin sensitivity and one very promising suggestion I've found is berberine. It's pretty similar to metformin which I know is highly looked down upon here and is a "metabolic toxin" according to @haidut so I am somewhat hesitant about it.
It apparently inhibits mitochondrial 1 complex, lowers the NAD/NADH ratio, and inhibits lactate dehydrogenase and pyruvate dehydrogenase. I don't really understand the precise science behind all of that beyond the fact that all of those things seem to be pretty important for metabolism. However, I'm wondering if I can avoid some of the damage berberine might cause by using things like CoQ10, Energin, and Pansterone (among other things). Also, Berberine apparently protects against metformin induced lactic acidosis, so I'm guessing it's not nearly as bad as metformin in the lactic acid department. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
On the other band, berberine is supposed to be really good at blocking the creation of new fat, nutrient partitioning, meaning that glucose gets into the muscles and not stored as fat, reversing fatty liver, improving gut health, and strongly boosting insulin sensitivity. It seems like it could really benefit me so I'd really like to give it a try if y'all think it's safe.
If not, what are the strongest things you would suggest for boosting insulin sensitivity? I've seen aspirin and niacinamide mentioned here a lot but I've also heard that they can hinder fat loss which I don't think would be good for my fatty liver or my overall health. Suggestions for strong things that can help me eat less while feeling more satisfied and most importantly sleep through the night would be greatly appreciated. I can only afford to buy one supplement for around $35 or so right now so I'm really trying to get the most value for my money.
Thanks so much! Any and all advice is greatly appreciated!