Anti-Psychotic Endocrine Disturbance Counters? + Some Back Story

Jwicks1995

Member
Joined
May 26, 2020
Messages
19
TLDR; Olanzapine (Zyprexa) is meant to majorly disturb the endocrine system, increase prolactin, lower testosterone etc. Is there a way to mitigate this? HCG? Pregnenolone? Not using the medication is not a possibility for this stage - at least until I stabilize. The dosage will be low - 2.5mg


So after many years of many varying pursuits at treating my health both physically and mentally, I think I've finally come across something that works. The Anti Psychotic - Zyprexa - although it is too early to tell - 2 days in I can actually FEEL again. My mind isn't stuck inside of a small box of avoidance and paranoia of every possibility of every bad thing possible.

My issues arose when I started to become EXTREMELY fatigued. Thought it was sleep apnea. Got tested. High AHI. although dodgy doctor looking back. Put on a CPAP. Things slowly got worse and worse. Got put on SSRI things got bad. Then discovered low carb/carnivore. BING BING BING! A light bulb in my head turns on! I'm cured! Or so I thought. After about a year on SSRI's I tapered off. And then surely but slowly things got REALLY BAD. I was extremely malnourished and super skinny. Not on any medication and eating OMAD Carnivore while still using a CPAP. (turns out I suffer from some sort of hypersensitvity to stimuli/allergies) and the CPAP was flaring my symptoms up so bad which presented as physical fatigue and mental disturbances i.e brainfog etc etc.

The icing on the cake was when I was experimenting with high doses of DHEA as it gave me alot more stamina and stress resistence. However, after about a month in i completely broke. Had a motorcycle accident because I was so anxious on the road, malnourished and stressed everynight hooked up to the hellish CPAP machine.

Since then I have been locked inside hell in my brain. Not as bad as before I stopped using CPAP though, the first night off that I wondered how the hell i'd never even gone one night off of it test what it'd feel like. Although I was much more tired the foggyness vanished like 50%. However most of these issues have stayed ever since.

Unfortunately, I'm back on an SSRI as I thought I'd screwed up my serotonin system. The past 3 months I've read much about raypeat. Implemented many of his methods. Cyproheptadine & Nortriptyline provided some relief - although it was hit and miss. And seemed to make me backed up. Anti- seretonin substances always seem to make me feel the most "normal" yet have never been able to find something that really works. Perhaps its actually the dopamine ANTAGONISM that is the icing on the cake for my brain. I've tried at least 30 different medications.

I feel so much more stable on Zyprexa - but I'm terrified about the weight gain and endocrine disturbances.
I have 5 adhp, progesterone & pregnenolone on hand luckily. My dose is small - going to go 5mg for the first week to tone down my hyperactive mind - and then down to 2.5mg for however long it takes to get to the route of my health. Whilst also SLOWLY tapering off of lexapro.
 

JudiBlueHen

Member
Joined
Jun 26, 2017
Messages
255
Recommend you stop all supplements while you stabilize on olanzapine (5mg, then to your goal at 2.5mg). Eat regularly and don't skip meals. Get some gentle exercise such as walking or easy cycling. Olanzapine is a very useful medication in spite of its known downsides. Get several weeks of increasing stability under your belt before you start experimenting with supplements, so you will know what effects they have and won't confuse them with your body's adjustment to zyprexa.
 

equipoise

Member
Joined
Jul 29, 2020
Messages
150
Location
Europe
Recommend you stop all supplements while you stabilize on olanzapine (5mg, then to your goal at 2.5mg). Eat regularly and don't skip meals. Get some gentle exercise such as walking or easy cycling. Olanzapine is a very useful medication in spite of its known downsides. Get several weeks of increasing stability under your belt before you start experimenting with supplements, so you will know what effects they have and won't confuse them with your body's adjustment to zyprexa.

Great post. OP take heed.
 

Uselis

Member
Joined
Feb 5, 2015
Messages
254
Here is my personal experience (just sharing so you can be more informed).

Due to my own stupidity I had very painful experience with psychiatry. Olanzapine was prescribed from 2.5mg and higher for insomnia. It took me very quickly to start gaining weight. Appetite became ravenous but my whole organism was so sedated that even walking became act of discipline. Emotions gone. Feeling like I was human being vanished.

During all of it I started to read a lot about Zyprexa and followed blogs on website where people were tapering such drugs. Here's what I found: nobody wins with Zyprexa long term (except manufacturers). Out of perhaps 20-30 personal stories I didn't find single one who wouldn't become overweight with time. Some people got diabetes from it. All of of them complained drug making them emotionless zombies also which I think is due to drug doing something to frontal lobe. Some got involuntary face movements (dyskynesia). I can't find exact post but some person digged up info where it's been counted that from Olanzapine invention till this day lots of people died from it. Number was in early thousands. People had really rough time tappering dose as low as 2.5mg and abrupt discontinuation send some to withdrawal lasting year.

I really think it's horrible drug and catches up quickly "long term". Not going to advice anything here but I felt I need to share this since I was on a drug myself and read decent amount of cases where Zyprexa did serious damage.
 

JudiBlueHen

Member
Joined
Jun 26, 2017
Messages
255
I took a low dose for about 6 months, gained 15 unwanted pounds, but was able to stop it without too much difficulty. It helped me get through a tough period. Can't say I'm a fan, but it was not terrible. I lost about 1/2 of the excess weight after stopping it.

It's hard to know if the deaths @Uselis mentioned were due solely to the drug - most likely there were other factors involved. With psychiatric drugs, there are usually multiple factors including the underlying illness, previous drug use, SMI-induced stress, etc.
 

aguineapig

Member
Joined
May 16, 2019
Messages
156
I would try other different 5-HT2A antagonists as that is probably where the therapeutic benefit is coming from.

Another quite safe drug to try (considered a pea shooter/placebo by most psychs) is buspirone, but it worked extremely well for me with no side effects. My theory is that it allows 5HT1A receptors (the negative feedback ones) to resensitize by shielding them from the much more powerful activation by our endogenous serotonin, which when chronically high would desensitize the receptors fairly quickly, and is often the case with psychiatric conditions
 
Similar threads
Thread starter Title Forum Replies Date
caspar Safer Alternatives To SNRI Cymbalta/Duloxetine And Anti-psychotic Abilify/Aripiprazole Supplements, Pharmaceutical Drugs 8
caspar Advice Getting Off SNRI And Anti-psychotic And Boosting Immune System Ask For Help or Advice 1
Michael Mohn Bifonazole, otc anti fungal, strong aromatase inhibitor, anti histamine, anti inflammatory Supplements, Pharmaceutical Drugs 2
Mauritio Allithiamine : a potent endotoxin-antagonist and anti-inflammatory Scientific Studies 3
Hans Top 6 Anti-Constipation Foods (#1 is a must eat) Articles & Scientific Studies 30
R Bixin carotenoide from annatto bean is anti-inflammatory, reduces carrageenan-induced paw edema in rats Scientific Studies 0
RealNeat The HighWire is the anti-venom to MSM Resources 0
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 15
Mauritio 10-methoxy-harmalan ,an anti-serotonin chemical? IdeaLabs 34
Mauritio Caprylic acid is anti-bacterial, lowers IL-8, helps Glioblastoma Fats 0
R Bad reaction to anti-biotic? Pharmaceutical Drugs 3
Harryedgar Anti -Peat - Fructose Increases Endotoxin? Sugar, Honey 0
D Good alternative to anti anxiety medication? Mental Issues 34
N Diamant / Adamantane usage as an anti-viral in the treatment of covid19? Ask For Help or Advice 0
haidut Glycine has a universal anti-viral effect Scientific Studies 38
haidut Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury Scientific Studies 2
haidut PUFA is catabolic, SFA is anti-catabolic (anabolic) Scientific Studies 0
D Anti Estrogenic Foods and Supplements Diet 3
johnwester130 Anti-Peat DHEA is an anti-androgen Debate - Anti-Peat 8
youngsinatra Unidentified Anti-Fatigue Factor in Beef Liver! Organ Meat 7
Lokzo Anti-Diabetic Herb No One Knows About Scientific Studies 0
L Minocycline Anti-depressive / SSRIs Pro-depressive Scientific Studies 1
O Methylene Blue As An Anti-COVID-19 Mouthwash In Dental Practice Articles & Scientific Studies 0
haidut Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho Scientific Studies 39
haidut Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho Scientific Studies 1
Jwicks1995 Seroquel/Quetiapine - Cortisol/Anti-Seretonin Cortisol, Serotonin, Histamine 37
JessFields Support For Anti-Snopes Sentiment? Ask For Help or Advice 20
Runenight201 Anti-natalism Meditation, Mindfullness, Religion, Spirituality 15
S Starting Anti Glycolytic Kettlebell Training Exercise 1
haidut Topical DHEA Has Potent Anti-aging Effects On Human Skin Scientific Studies 8
haidut Simply Diluting "old Blood" Has The Same Anti-aging Effects As Parabiosis Scientific Studies 43
Lewis Acid Eugenol: Helps Reduce Loss Of Dopamine / Protects From Aluminum / Neuro-protective & Anti-stress Scientific Studies 12
Randle Cyclist Cannabis: Pro Or Anti-metabolic? Alcohol, Tobacco, Drugs 73
F Testosterone "optimization" Stack And Anti-aromatase Ask For Help or Advice 13
F Need For An Anti-aromatase? Male Issues 28
F Anti Aromatase Needed In My Stack? Blood Work, Labs 0
F Refute Anti Peat Paper? (Unsaturated Cell Membranes Good) Scientific Studies 6
haidut Anti-histamines May Prevent, Treat Melanoma Scientific Studies 3
haidut "Anti-aging" Hormone (hGH) May Actually Shorten Life Scientific Studies 3
L RP Is Anti-authoritarian But I'm Starting To View RP As An Authority And Losing My Critical Thinking Miscellaneous 49
ImprovingDaily What Are Some Good Herbal Or Otc Anti Serotonin Supplements You've Tried? Cortisol, Serotonin, Histamine 5
Soren Brother Died Need Anti-depressant Advice Cortisol, Serotonin, Histamine 82
zarrin77 Ginkgo Biloba Is Anti-Serotonin And Pro-Dopamine Scientific Studies 7
Hans Serotonin, The Fraudulent Anti-depressant Articles & Scientific Studies 20
alywest Losartan As Anti-coagulant, Possible Explanation For Success In COVID Patients? Viruses, Parasites, Fungus, Vaccines 1
Broken man Anti-inflammatory Effects Of Benfotiamine Are Mediated Through The Regulation Of The Arachidonic Aci Scientific Studies 2
F Byeabetes: T1, Raffinose, Anti-Inflammatory Suggestions? Ask For Help or Advice 0
zarrin77 Glycine (and Serine) Have Potent “anti-depressive” Effects In Rodent Endotoxin Model Scientific Studies 0
jzeno Hydroxychloroquine And Now This: Anti-parasite Ivermectin Could Kill Off COVID-19 Cells In Two Days Articles & Scientific Studies 1
Hans Inhibiting Lipolysis Can Have Anti-aging Effects Scientific Studies 15

Similar threads

Top