Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Click Here if you want to upgrade your account
If you were able to post but cannot do so now, send an email to admin at raypeatforum dot com and include your username and we will fix that right up for you.
burtlancast said:Well, that's very interesting.
THC seems to have similar effects on libido as progesterone .
Blossom said:Several years ago I read a book called Botany of Desire that devoted an entire chapter to cannabis. As a person who grew up around it in the home, but never personally liked it myself, it gave me a better understanding of the plant and it's appeal. I know you definitely can't overdose on it like alcohol and most street drugs and narcotics so in that respect it is safer than many substances. I always hated seeing people intubated in the ER just because they were stoned. Obviously those physicians needed to brush up on their toxicology! It does something for some people or it wouldn't be so widely popular. I'm just glad I never developed the habit because of the estrogenic properties. My weakness was always nicotine. Oh to be human.
I know a friend that made some up in the high desert out in California, legally. He didn't make it for cancer, he just made it for an experiment. But yeh I have been aware of Rick Simpson for many years.burtlancast said:Have you heard about Rick Simpson and his cannabis oil ?
The stuff is incredible as far as treating many diseases.
Blossom said:I suppose it could be valuable if it kept one away from even more dangerous medical interventions.
Blossom said:I hadn't heard of him. My daughter's college roommate was an herbalist who made a tincture with it using vodka. I often thought that might be helpful for people trying to stop smoking it, at least no more harm to the lungs would occur.
http://www.takepart.com/article/2014/03 ... foodinc-fbA recent study shows that more Americans now believe that weed is the lesser of two evils. The Hart Research Associates polled 1,000 adults, asking them which substance they thought caused the most harm to a person’s health: tobacco, alcohol, sugar, or marijuana.
Of course marijuana is estrogenic.
Marijuana: interaction with the estrogen receptor.Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9-tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabinol metabolites also failed to compete with estradiol for its receptor. Of several other common cannabinoids tested, only cannabidiol showed any estrogen receptor binding. This was evident only at very high concentrations of cannabidiol. Apigenin, the aglycone of a flavinoid phytoestrogen found in cannabis, displayed high affinity for the estrogen receptor. To assess the biological significance of these receptor data, estrogen activity was measured in vivo with the uterine growth bioassay, using immature rats. Cannabis extract in large doses exhibited neither estrogenic nor antiestrogenic effects. Thus, although estrogen receptor binding activity was observed in crude marijuana extract, marijuana smoke condensate and several known components of cannabis, direct estrogenic activity of cannabis extract could not be demonstrated in vivo.
Antiestrogenic effects of marijuana smoke condensate and cannabinoid compoundsThe antiestrogenic effects of marijuana smoke condensate (MSC) and three major cannab-inoids, i.e., Δ9-Metrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN), were evaluated usingin vitro bioassays,viz., the human breast cancer cell proliferation assay, the recombinant human estrogen receptor (ER) competitive binding assay, and the reporter gene assay. The inhibitory effects on estrogen were also examined using the ethoxyresorufin-O-deethylase (EROD) assay, the aromatase assay, and the 17β-estradiol (E2) metabolism assay. The results showed that MSC induced the antiestrogenic effectvia the ER-mediated pathway, while THC, CBD, and CBN did not have any antiestrogenic activity. This suggests that the combined effects of the marijuana smoke components are responsible for the antiestrogenicity of marijuana use.
It's interesting though because in Ray Peat's most recent newsletter he lists drinking coffee or alcohol, smoking, and taking aspirin as protective to the substansia nigra in context of Parkinson's disease. So perhaps it's more complicated than calling something either estrogenic/adrenergic?It's ironic that my pharmocologist cousin just yesterday recommended I use vaporized marijuana for nausea and he's the same guy that gave me unsolicited dietary advice to avoid sugar! It's a mixed up world I tell ya! I still love him I just wouldn't necessarily take his advice.
Have you still quit weed Cliff?Smoke is estrogenic. I think getting high creates a stress response and surge of adrenaline, I've recently quit smoking marijuana pretty much all together for this reason.
If you do it using a vaporizer or ingesting it orally is probably your best bet.