Candida Overgrowth Is A Major Factor In (alcoholic) Liver Damage / Cirrhosis

Discussion in 'Scientific Studies' started by haidut, May 23, 2017.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    Over the last 5 years or so it has become very fashionable among many "naturopaths" to throw the diagnosis "Candida overgrowth" at every symptom of gut dysfunction people present with at the doctor. Peat has spoken about Candida overgrowth and how the fungus typically only becomes an issue in people with suppressed immune systems or people on low-carb diets attempting to starve the fungus.
    This study shows that Candida can in fact contribute to the development of alcoholic liver disease and its effects can be blocked by administering an anti-fungal agent. Another interesting finding is that the Candida overgrowth was caused by alcohol abuse itself, due to reduced bacterial count and reduced diversity of remaining bacteria in the gut of alcoholics. In addition, alcohol increased the permeability of the intestine and the absorption of beta-glucans into the bloodstream. The beta-glucans are the fungal equivalent of bacterial endotoxin (LPS) and are found in some bacteria as well. Perhaps more importantly, the beta-glucans are also agonists of the infamour TLR4 receptor, which has been implicated in virtually all liver/gut conditions. All in all, it looks like the mechanism for liver damage is virtually the same as in bacterial endotoxin - alcohol increases intestinal permeability and endotoxin levels in the blood, which then reaches the liver through the portal system and causes chronic inflammation via activation of TLR4, and ultimately liver fibrosis.
    Given charcoal's anti-fungal (as well as anti-bacterial) effects, it could serve the same purpose as the anti-fungal medication and protect against endotoxin. Alternatively, a TLR4 antagonist could also help mitigate the inflammatory damage exerted by these fungal byproducts. Some OTC anti-fungal remedies include methylene blue, niacinamide, and aspirin and incidentally all 3 have shown beneficial effects in various liver pathologies.

    JCI - Intestinal fungi contribute to development of alcoholic liver disease

    "...Commensal fungi have important functions in health, but alterations in the intestinal mycobiota have been associated with disease (8, 31). Our study links compositional changes of the intestinal mycobiota to progression of alcoholic liver disease. Chronic alcohol abuse is associated with fungal dysbiosis in mice and humans. Fungal cell wall components, mainly β-glucan, translocate from the intestinal lumen to extraintestinal spaces that include the liver. Binding of β-glucan to CLEC7A on Kupffer cells and possibly other bone marrow–derived cells promotes alcoholic liver disease by inducing hepatic inflammation, ultimately leading to steatosis and cell death of hepatocytes. Preventing fungal overgrowth protects mice from ethanol-induced liver disease (Figure 7). In our human cohort, the degree of exposure to fungal products correlates with mortality of patients with cirrhosis from alcohol abuse but not viral hepatitis. Although a larger, prospective study is required to confirm data from our retrospective analysis of a human cohort with a relatively small number of patients, our findings support the importance of the mycobiota for patients with alcoholic liver disease."

    "...We have identified a cross-talk between bacterial and fungal pathogen-associated molecular patterns (PAMPs) during alcoholic liver disease. Hepatic IRAK3, a negative regulator of TLR signaling (24), was increased after reduction of an alcohol-associated increase in intestinal fungi. IRAK3-deficient mice are more susceptible to alcohol-induced liver injury (39). This indicates that in the absence of fungal PAMPs, bacterial signaling through TLRs and MYD88 is inhibited. A synergism between bacterial and fungal PAMPs is necessary for development of ethanol-induced liver disease."

    "...Our study demonstrates an important role of fungal dysbiosis in the development of alcoholic liver disease. We found that antifungal drugs prevented ethanol-induced steatohepatitis in mice. This therapeutic strategy can easily be translated into clinical practice, because oral amphotericin B has no systemic side effects and is well tolerated by patients. Alcohol-associated fungal dysbiosis in humans is characterized by a large increase in Candida, which is susceptible to amphotericin B. The effects of this drug should be tested in patients with alcohol-related liver disease, who are in urgent need of new therapeutics. Manipulation of the intestinal mycobiome might be an effective strategy for attenuation of alcohol-related liver disease."
     
  2. TubZy

    TubZy Member

    Joined:
    Sep 30, 2016
    Messages:
    1,649
    Gender:
    Male
    Location:
    USA
    Also, naltrexone. It is a TLR4 antagonist as well along with other mechanisms of being anti inflammatory let alone being a strong immune modulator. The only reason it popped in my head is because I have been experimenting with it this week.

    What also makes sense is that naltrexone is also used for alcohol withdrawals...
     
  3. beachbum

    beachbum Member

    Joined:
    Nov 10, 2014
    Messages:
    423
    Gender:
    Female
    If I heard it correctly on a radio interview with RP that he mentions flowers of sulfur for candida and maybe something else too.

    edit: I found this:
     
  4. Lucenzo01

    Lucenzo01 Member

    Joined:
    May 17, 2016
    Messages:
    345
    Keep this in mind: everything that it's good for health is antifungal in some way. The best way to check if you have candida is measuring your levels of beta-alanina in the blood. If it's high, you have Candida overgrowth. I would bet that 95% of people have Candida if not more. Antibiotics are killing us and it's the worst face of the Peaty world.
     
  5. Tarmander

    Tarmander Member

    Joined:
    Apr 30, 2015
    Messages:
    2,940
    Gender:
    Male
    Anyone know Peats take on beta glucans? They are found in yeast like this study shows, but I know they are also found in oat meal and mushrooms, but perhaps there are different kinds? Would be curious if anyone has ever heard him say anything about those. Haidut?
     
  6. Dobbler

    Dobbler Member

    Joined:
    Jun 19, 2016
    Messages:
    493
    Gender:
    Male
    Many people at different forums have managed to "cure" candida with zero fat fruitarian diet (10/10/80). I wonder if Peat diet with 0 fat could do the same. Mby it has something to do with PUFA.
     
  7. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    Yes, thanks. Naltrexone is also a great option.
     
  8. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    That's a great find, thanks. So, towards the end of the excerpt he says that the sulfur can clean the intestine from bacteria as well. I wonder why he does not recommend this as a periodic and safer treatment for gut issues instead of antibiotics??
     
  9. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    I don't know his take on them but they are not much different from LPS as per the study, as they also activate TLR4. Not sure if the dietary sources have the same effect, but I would not load myself up on beta glucans if possible. I know it is promoted as gut cleansing treatment on some blogs, and I think that is dangerous.
     
  10. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    If sulfur works as well as Peat claims, then using it for 2-3 days is probably safer and less drastic than going on fat-free diet for a month.
     
  11. Tarmander

    Tarmander Member

    Joined:
    Apr 30, 2015
    Messages:
    2,940
    Gender:
    Male
    Thanks! Seeing as Ray did not mention the beta glucans in Mushrooms, I am guessing it was not worth worrying about given proper cooking.
     
  12. Regina

    Regina Member

    Joined:
    Aug 17, 2016
    Messages:
    1,869
    Gender:
    Female
    Location:
    Chicago
    Maybe Dave can come up with a witty name for an Idea Labs version.
     
  13. Such_Saturation

    Such_Saturation Member

    Joined:
    Nov 26, 2013
    Messages:
    7,368
    o_O
     
  14. Lucenzo01

    Lucenzo01 Member

    Joined:
    May 17, 2016
    Messages:
    345
    "Another interesting finding is that the Candida overgrowth was caused by alcohol abuse itself, due to reduced bacterial count and reduced diversity of remaining bacteria in the gut of alcoholics"

    Directly from the study. Antibiotics do exactly the same thing.
     
  15. Such_Saturation

    Such_Saturation Member

    Joined:
    Nov 26, 2013
    Messages:
    7,368
    So does a beer reach the colon unabsorbed, and gets concentrated into an antibiotic 50% concentration of alcohol?
     
  16. TubZy

    TubZy Member

    Joined:
    Sep 30, 2016
    Messages:
    1,649
    Gender:
    Male
    Location:
    USA
    Most of the threads/logs I read on here didn't notice anything from flowers of sulfur, not sure why though
     
  17. Lucenzo01

    Lucenzo01 Member

    Joined:
    May 17, 2016
    Messages:
    345
    Not only the colon has beneficial bacteria.
     
  18. Such_Saturation

    Such_Saturation Member

    Joined:
    Nov 26, 2013
    Messages:
    7,368
    But this veers pretty sharply from Ray Peat ideas... are you only here for the anti Candida parts? For example, Ray Peat likes tetracyclines for more than their antibiotic action.
     
  19. bzmazu

    bzmazu Member

    Joined:
    Oct 29, 2015
    Messages:
    1,211
    Gender:
    Male
    Location:
    Corozal, Belize
  20. beta pandemic

    beta pandemic Member

    Joined:
    Jul 25, 2016
    Messages:
    153
    Gender:
    Male
    Location:
    Melbourne
    are you suggesting a link between infections (including candida) and cancer?

    Dont want to derail the thread but I'd like to know what dose you took and for how long. This is huge and could help a lot of people. maybe make a thread
     
Loading...