The synthesis of inflammatory chemoattractant leukotriene B4 increases as lipoxygenase increases, resulting in recruiting neutrophils to generate more ROS. Inhibition of this process will improve acne
There's truth to this. A while back I came across papers stating a connection between skin problems and mast cell activation and oxidative stress, and all of that is exacerbated by bugs. I started suffering from dermatitis, acne, scaliness, etc, since a few years ago and neither diet nor supplements have helped significantly. So out of curiosity, without too many expectations, I put the mast cell and oxidative stress theory to test. I made my own cream containing a 5-lipoxygenase inhibitor (because 5-LOX is one of the main non-mitochondrial sources of ROS and generates leukotrienes), a mast cell activation/degranulation inhibitor and an antimcrobial. After a few days of my cream treatment, my skin was better than ever, dermatitis and itchy patches gone, pores normalized, acne gone, even tone, silkiness, porcelain texture, great elasticity, so much so people started commenting on my skin! It's impressive.Anti-inflammatory ability, anti-microbial activity against P acnes and a potential to reduce sebum production
The connection with mast cells is that these are abundant in the skin and they can get activated or degranulated under chronic stress conditions. The factors they produce have been shown to play key roles in increased sebum production and/or promote proliferation of sebaceous glands, vasodilation, proliferation of nerve fibers in the skin that add to increased sensitivity, besides producing factors that increase oxidative stress.
Thanks for sharing!
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