I'm not sure, it does give some dosage instructions on the page I linked to, down towards the bottom of the page. It recommends starting out with two capsules.Yeah, I knew it was NDT, but since it is not an extract, I was wondering if that affected the dosage rate if someone was going to compare it to an extract. I agree that it is probably the closest to the real thing, like eating thyroid glands the way our ancestors would do. Haven't tried it yet, currently doing Tyromix, but I want to give it a go sometime to see how it is.