T3 Dose For Hypothyroidism Matches Dr. Peat's Recommendations

[DaveFoster]

In their 2017 study, Celi and others studied the effects of liothyronine (T3) in the treatment of hypothyroidism, and they found that a 0.34 ratio of T3 to T4 resulted in a euthyroid state. For reference, this would be something like 34 mcg of T3 for every 100 mcg of T4, which matches exactly the ratio that Dr. Peat recommends in his article, Thyroid: Therapies, Confusion, and Fraud.

Relevant excerpts from either written piece lie below.

...we systematically assessed the differences in the targets of the TH action, measured at a clamped, euthyroid state in the pituitary. The 0.34 ± 0.05 μg/μg ratio of l-T3/l-T4 daily dose is in agreement with previous estimates obtained by compartmental analysis (29). Although the mean serum T3 level remained within the normal range, l-T3 treatment resulted in significantly higher T3 serum concentrations. This is not surprising because type-2 deiodinase (30) is particularly active in the thyrotroph, and it is thought to play a major role in the hypothalamus-pituitary-thyroid axis (27, 31). Hence, this axis is probably more responsive to the inhibitory effects of T4 than T3.

The brain concentrates T3 from the serum, and may have a concentration 6 times higher than the serum (Goumaz, et al., 1987), and it can achieve a higher concentration of T3 than T4. It takes up and concentrates T3, while tending to expel T4. Reverse T3 (rT3) doesn't have much ability to enter the brain, but increased T4 can cause it to be produced in the brain. These observations suggest to me that the blood's T3:T4 ratio would be very "brain favorable" if it approached more closely to the ratio formed in the thyroid gland, and secreted into the blood. Although most synthetic combination thyroid products now use a ratio of four T4 to one T3, many people feel that their memory and thinking are clearer when they take a ratio of about three to one. More active metabolism probably keeps the blood ratio of T3 to T4 relatively high, with the liver consuming T4 at about the same rate that T3 is used.

 

[michael94]

Do you know the ratio in cynoplus off the top of your head?

 

[DaveFoster]

Do you know the ratio in cynoplus off the top of your head?

It's around one part T3 to four parts T4.

 

[RPDiciple]

Cool. I would like to see their dosing frequency etc. Seems like research does not think you need to space out the thyroid dosage but RP says dont to much t3 at once.

 

[ecstatichamster]

 

[managing]

Cool. I would like to see their dosing frequency etc. Seems like research does not think you need to space out the thyroid dosage but RP says dont to much t3 at once.

Perhaps the .34 ratio resolves that?

 

[Pufas Shmoofas]

Something in between Cynoplus and TyroMix would be the sweet spot it seems!

 

[sweetpeat]

I'm not sure it means what you think it means. None of the study participants used a t3/t4 combination. They used either t3 only or t4 only.

Here is the stated objective for the study: "Our objective was to evaluate the efficacy of thyroid hormone replacement with l-T4 or l-T3 at doses producing equivalent normalization of TSH."

They discovered that the substitution rate of t4 to t3 is .34. So substituting, say, 34mcg t3 for 100mcg t4 should give an equivalent TSH. T3 seems to be basically 3 times as strong as t4, at least in regards to affecting TSH. This could, of course, have implications for t3/t4 combination therapy, but that's not what they were studying.

@RPDiciple They took either t3 or t4 three times a day before meals.

 

[Sagitarrius90]

So 25-50 mcg seems to be the full replacement dose - 25 mcg full replacement with someone whose healthy 50mcg being a full replacement with someone with no functioning thyroid.

 

[Sagitarrius90]

So why would one want to take that amount exogenously when it would cause suppression and you get off then become hypothyroid again?

 

[NewACC]

So why would one want to take that amount exogenously when it would cause suppression and you get off then become hypothyroid again?

in fact, even milligram doses of t3, which caused a severe thyroid storm and completely suppressed endogenous thyroid function, returned to normal in just 2-3 days. And these were almost toxic doses of t3 for human