Last Before And After NDT - Cholesterol Higher With Lower TSH

[rmorloc1]

Hello -

After years of running, low carb and low sugar eating with lots of green smoothies.... I came across Ray Peat. Below are initial labs, labs following high dose niacin to lower cholesterol, and labs after 5-6 weeks of NDT. The initial 5-6 weeks of diligent Peating (OJ, milk, collagen, sugar, coffee, aspirin, EstroBan) the labs show TSH and cholesterol not moving as anticipated - lowering TSH is not lowering cholesterol. Pulse is up (high 70s low 80s) and temps are up from 97.3-97.5 to 97.5-97.8. Welcome any thoughts/comments/recommendations.

July 21, 2016 - INITIAL Labs
Total Cholesterol=268 mg/dL
HDL=48 mg/dL
Trig=132 mg/dL
LDL=194 mg/dL

T3 Uptake=32
T4 (Throxine) Total=8.5mcg/dL
Free T4 Index (T7)=2.7
TSH=3.9 mIU/L

T3 Reverse, LC/MS/MS=20
T3 Total=104
T4 Free=1.3

September 9, 2016 - Labs Following 2-3 grams of niacin per day for 5-6 weeks
Total Cholesterol=207 mg/dL
HDL=54 mg/dL
Trig=64 mg/dL
LDL=140 mg/dL
TSH = 3.5 mIU/L

November 2, 2016 - Labs following 5-6 weeks of NDT with last 2 weeks 2.0-2.5 grains per day and No Niacin. Labs pulled 6 hours after last dose of NDT.
Total Cholesterol=275
HDL=34
Trig=204
LDL=200

T3 Uptake=33 (22-25%)
T4 (Throxine) Total=7.3 (4.5-12)
Free T4 Index (T7)=2.4 (1.4-3.8)

TSH=1.87 mIU/L (0.40-4.50)
T3 Reverse, LC/MS/MS=11 ng/dL (8-25)
T3 Total=123 ng/dL (76-181)
T4 Free=1.1 ng/dL (0.8-1.8)
T3, Free=4 ng/dL (2.3-4.2)
THYROGLOBULIN ANTIBODIES=3 IU/mL (<1)

THYROID PEROXIDASE ANTIBODIES=367 (<9)


This week I am starting 3 grains NDT a day (1 grain 3 times a day) as I try to increase temps. Peat does not recommend niacin... it did lower my cholesterol - I am planning to reintroduce it for the next 5-6 weeks and then run cholesterol and thyroid labs again. Welcome any thoughts/comments/recommendations.

Thanks,
Rob

 

[Steve]

Doesn't the TPO point to autoimmune thyroid disease? You're at 356 & supposed to be <9.
I just started NDT 34 days ago & have had absolutely no change in temperature or pulse. Just started 2 grains 5 days ago.
Did you notice changes right away?

 

[rmorloc1]

Hi Steve,
Apparently this indicates Hashimoto's Disease. As far as I can tell, treatment for hypo is the same with or without Hashimoto. I noticed some increased energy in the 2nd week and then it went away. This week, 3 grains a day (3am, 8am, and 1pm) seems to be creating more energy and I like being back on Niacin. Planning to pull labs again in 4-5 weeks and we'll see if I can get TSH below 1 and lower cholesterol and trigs.
Thanks for replying.
Rob

 

[Steve]

I think treatment as far as thyroid replacement would be the same, but since you have an autoimmune disease that's a whole 'nother subject. Apparently it's possible to get it into remission, but what a pain in the **** trying to figure it out !