Okay thanks for the explanation. I can definitely see the merits in this, since it's been shown that prolactin is elevated in the scalp of balding men (along with a variety of other stress hormones). And even something as basic as stopping frequent ejaculation (which drastically triggers prolactin) has stopped the itching and slowed hair loss in a lot of men. I can see how this medication could help some people. Also, Peat recently recommended Bromocriptine to someone reporting skin issues, who also had slightly elevated prolactin. The bromo fixed all of his skin problems. If this medication is successful, it may also help against some skin problems, sebhorric dermatitis, etc.The pituitary PRL secretion can be inhibited by use of bromocriptine and other dopamine receptor 2 agonists (Nature Clinical Practice Endocrinology and Metabolism 2(10): 571-581, 2006). These agents, however, do not suppress extrapituitary PRL synthesis that can compensate successfully for the inhibition of pituitary PRL synthesis leading to almost unimpaired PRLR-mediated signaling (Endocrine Reviews 19:225-268, 1998).
(WO2019011719A1 - Prolactin receptor antibody for male and female pattern hair loss - Google Patents)
Hair follicles synthesize their own prolactin which remains unphased by common means of reducing systemic prolactin. BAY 1158061 is a prolactin receptor antibody which effectively neutralizes PRL inside of the cell. The hair growth trials showed it continued to work even for months after quitting the drug, so clearly it does something that just taking B6 or Bromo cannot do.
I guess we could debate what the reason is for prolactin being a problem in the follicles but as long as it gives people who can't tolerate antiandrogens an alternative with less side effects (or positive ones), I'm not going to be too fussed whether it's the "right" way of fixing this.
But I still don't believe it will help everyone, and I'm sure there will be some negatives effects, as with all medication. I'm sure a bioenergetic approach along with this would still be greatly beneficial. And this may be years away, if it even does get approved, so best to start now for anyone who may be waiting for this.
We should try to keep on topic however, and bring this back to DHT. Something which I didn't mention before, the guy in the photos I linked has reported that since 7-8 months ago, his T and DHT levels have skyrocketed. So there's one more anecdote to add to the 'DHT doesn't cause hair loss'.
Also great post @Hans. And great interview with Sam Empie. I've already recommended these to a few of my friends.