I saw this comment on a thread (about thiamine)
It made me think about something I experienced with niacin months ago. I was taking about a gram every day. The first few days there was mental spaciness. Short-term memory issues. It felt like some part of my brain wasn't working right.
Maybe this was due to the liberation of toxins from fat—something niacin is known for.
But according to TheSir it could be indicating I was deficient.
Niacin deficiency is associated with skin problems, cognitive decline like memory problems and dementia, and GI problems like loose stool. For most of my life (I'm in my early twenties right now) I have had cognitive problems and chronic loose stool. Unable to work because my mind has no energy and also insomnia.
Elliot of EO Nutrition has talked about how nutritional deficiencies could theoretically only be affecting certain organs. So perhaps my skin was never deficient, but my my brain and GI system were.
In addition to this, I experienced something on the fourth and fifth day of supplementing. It was remarkable and indeed made me feel as if I was severely deficient. You have heard of the Limitless Pill probably. Infinite energy, boosts IQ, abundance of confidence and motivation. Well this is what I felt on those days. As if a major deficiency had been corrected and cellular energy across my body was restored to how it should be. (there are more details in my thread if interested)
This was not mania because it had actually relaxed me, my nerves, my head. I was able to feel a sleepy sensation. It cured my insomnia. Additionally I noticed a change in stool quality. It had fixed my gut during those days.
The puzzle is that ever since that fourth and fifth day I haven't felt anywhere near to that. The way I feel is exactly like before that experience. Zero energy. Insomnia. Loose stool.
Does this sound like a deficiency? Does the paradoxical reaction occur with nutrients other than thiamine?
The only permanent change I've noticed since taking niacin is it has allowed me to go from using 3 lb dumbbells to 20 lbs. (for years I was trying to gain strength and never could)
With schizophrenia it can take years of supplementing niacin before improvements are seem. There is also an approach where massive doses are used to see results quicker.
How is that possible if it is only correcting a deficiency? (according to Dr. Abram Hoffer)
The best theory I've come up with is that maybe a leaky blood-brain barrier allowed lots of niacin into my brain at the beginning but then it repaired the blood-brain barrier.
pubmed.ncbi.nlm.nih.gov
This would limit the amount of niacin getting to the brain, preventing a full recovery because a certain threshold of supply is never met due to the NAD-starved cells too quickly picking up and spending any niacin that gets in.
But then again, I don't even know if I was/am deficient...
If you want to see the results of 50 gram+ check out this thread. I will be evaluating the BBB-bottleneck theory. The thread addresses safety concerns.
raypeatforum.com
It made me think about something I experienced with niacin months ago. I was taking about a gram every day. The first few days there was mental spaciness. Short-term memory issues. It felt like some part of my brain wasn't working right.
Maybe this was due to the liberation of toxins from fat—something niacin is known for.
But according to TheSir it could be indicating I was deficient.
Niacin deficiency is associated with skin problems, cognitive decline like memory problems and dementia, and GI problems like loose stool. For most of my life (I'm in my early twenties right now) I have had cognitive problems and chronic loose stool. Unable to work because my mind has no energy and also insomnia.
Elliot of EO Nutrition has talked about how nutritional deficiencies could theoretically only be affecting certain organs. So perhaps my skin was never deficient, but my my brain and GI system were.
In addition to this, I experienced something on the fourth and fifth day of supplementing. It was remarkable and indeed made me feel as if I was severely deficient. You have heard of the Limitless Pill probably. Infinite energy, boosts IQ, abundance of confidence and motivation. Well this is what I felt on those days. As if a major deficiency had been corrected and cellular energy across my body was restored to how it should be. (there are more details in my thread if interested)
This was not mania because it had actually relaxed me, my nerves, my head. I was able to feel a sleepy sensation. It cured my insomnia. Additionally I noticed a change in stool quality. It had fixed my gut during those days.
The puzzle is that ever since that fourth and fifth day I haven't felt anywhere near to that. The way I feel is exactly like before that experience. Zero energy. Insomnia. Loose stool.
Does this sound like a deficiency? Does the paradoxical reaction occur with nutrients other than thiamine?
The only permanent change I've noticed since taking niacin is it has allowed me to go from using 3 lb dumbbells to 20 lbs. (for years I was trying to gain strength and never could)
With schizophrenia it can take years of supplementing niacin before improvements are seem. There is also an approach where massive doses are used to see results quicker.
How is that possible if it is only correcting a deficiency? (according to Dr. Abram Hoffer)
The best theory I've come up with is that maybe a leaky blood-brain barrier allowed lots of niacin into my brain at the beginning but then it repaired the blood-brain barrier.
Niacin mitigates blood-brain barrier tight junctional proteins dysregulation and cerebral inflammation in ketamine rat model of psychosis: Role of GPR109A receptor - PubMed
Dysregulated inflammatory responses and blood-brain barrier (BBB) dysfunction are recognized as central factors in the development of psychiatric disorders. The present study was designed to evaluate the effect of niacin on BBB integrity in ketamine-induced model of psychosis. Meanwhile...
pubmed.ncbi.nlm.nih.gov
This would limit the amount of niacin getting to the brain, preventing a full recovery because a certain threshold of supply is never met due to the NAD-starved cells too quickly picking up and spending any niacin that gets in.
But then again, I don't even know if I was/am deficient...
If you want to see the results of 50 gram+ check out this thread. I will be evaluating the BBB-bottleneck theory. The thread addresses safety concerns.
Super Dosing Niacin -- A Half Cup and More
What justifies you doing this? Extensive knowledge about nutraceuticals. Chronic debilitating problems with health. Unable to seek professional help due to life circumstances. Risk minimized by careful planning and consideration. There have been reports of 100 grams of niacin consumed at...
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