Niacinamide + Vit C = Niacin?


Mar 27, 2018
Recently I saw an ad for a popular skincare brand called "The Ordinary" which contains 10% Niacinamide.
The commercial stated that if you use any sort of Vitamin-C containing product, to use it apart from the Niacinamide cream. That is, several hours apart.

Their rationale for this was that Vitamin C can catalyze the formation of Niacin from the Niacinamide, and as we know Niacin is responsible for skin flushing/redness.

I thought this was a small concern, because I used to mix my OJ with Niacinamide.

Niacinamide is a pretty “tough” ingredient; light and air don’t have the same effect on it as they do on antioxidants like vitamin C. What’s important for niacinamide is that the product be formulated at a pH that’s close to neutral. Vitamin C (pure ascorbic acid), on the other hand, does best in a low-pH (acidic) environment. However, nicotinic acid—the undesirable by-product of niacinamide and vitamin C—becomes an issue only when the niacinamide and vitamin C are combined in a high-temperature environment for a long time. That temperature is higher than you’d find in most at-home scenarios, including leaving a box of skin care products sitting outside in the sun for a couple of days.
Can Niacinamide and Vitamin C Be Used Together? | Paula's Choice

This article doesn't state what that "high-temeprature" is but I wonder if being combined in a 98.6 degree stomach and being churned around is sufficient to catalyze the formation of Niacin from Niacinamide+Vit C.
Obviously a cosmetics manufacturer is not a "scientific" source, but they would be inclined to produce a product that benefits skin, and does not cause further issues - which Niacin does
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