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Niacin And Niacinamide At The Same Time?

Discussion in 'Vitamins' started by Lucenzo01, Feb 17, 2018.

  1. Lucenzo01

    Lucenzo01 Member

    Joined:
    May 17, 2016
    Messages:
    341
    Found this on another forum:

    "Simply speaking, the body's natural liver detoxification process involves two steps; Phase 1 and Phase 2. A toxin initially enters Phase 1, the P-450 cytochrome system, and is reduced to smaller fragments. These fragments then progress to Phase 2, where they are bound to molecules such as glutathione, glycine and sulfate. This process creates a new non-toxic molecule that can be excreted in the bile, urine or stool.

    In effect, Phase 1 either directly neutralizes a toxin, or modifies the toxic chemical to form activated intermediates which are then neutralized by one of more of the several Phase 2 enzyme systems. In Phase 1, a toxic chemical is converted into a less harmful chemical. This is achieved by various chemical reactions (such as oxidation, reduction and hydrolysis), and during this process free radicals are produced which, if excessive, can damage the liver cells. Antioxidants reduce the damage caused by these free radicals. If antioxidants are lacking and toxin exposure is high, toxic chemicals become far more dangerous. Some may be converted from relatively harmless substances into potentially carcinogenic substances.

    One or both detoxification phases can be inefficient or overloaded. A particularly damaging combination in an ill person is an excessive overload of toxins coming into Phase 1, with an inefficient Phase 2. In some cases this combination is believed to be the cause of marked environmental sensitivities, drug intolerances and interactions that characterize many chronic fatigue and fibromyalgia patients."

    http://www.diagnose-me.com/treat/T355489.html

    Niacinamide slows down phase 1, while niacin speeds up phase 2. Niacin is also known as inositol hexanicotinate, vitamin B3 and nicotinic acid.

    As an interesting aside, there was a study last year at I believe Caltech Berkley, where they used high doses of niacinamide with 100% success in reversing the rodent equivalent of Alzheimer's. Naturally, the researchers cautioned against anyone trying to do the same thing with humans and of the dangers of taking supplements - despite the fact that niacin and niacinamide have a virtual 100% safety record. I believe that the proper interpretation was to not take any such supplements until they can produce a patentable version to market.

    All the best,

    DQ
     
  2. DesertRat

    DesertRat Member

    Joined:
    Mar 10, 2014
    Messages:
    116
    Very interesting. I think it would be helpful to know two things:
    how much time between Phase I and Phase II -- in order to space out the niacinamide and niacin
    and, does excess niacinamide convert to niacin, or vice versa?

    I foudn this intersting as my Phas 1 tested very rapid at the time I developed chemical sensitivity, and I do quite well on niacinamide. But I didn't like taking niacin at all.
     
  3. ddjd

    ddjd Member

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    2,780
    Is slowing down phase 1 a good thing?
     
  4. DK580

    DK580 Member

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    Jul 30, 2017
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    Yes, because sometimes the result of phase 1 is an even more toxic substance than what was started wuth, in which case it's better to have phase 1 slowed down so it doesn't make the body more toxic faster than phase 2 can handle it.

    Reference:
    Detoxification pathways in the liver.
    Detoxification pathways in the liver. - PubMed - NCBI
    "However, some chemicals may also be converted to more toxic metabolites"
     
  5. MrThyroid

    MrThyroid Member

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    what do you think about taking liposomal glutathion, beside eating glutathion boosting foods
     
  6. magnesiumania

    magnesiumania Member

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    Hey, im new to this forum. Im a little concerned that niacin is made from coal tar derivatives and formaldehyde. Does Ray Peat recommend synthetic niacin i higher doses?
     
  7. ddjd

    ddjd Member

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    im also keen to know this. a lot of haiduts supplements actually work to lower GSH!
    so another reason why niacinamide is much more preferable to regular niacin
     
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