raypeatclips
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Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer
Cancer Res. Author manuscript; available in PMC 2015 Aug 15.
Published in final edited form as:
Cancer Res. 2014 Aug 15; 74(16): 4398–4408.
Published online 2014 Jun 17. doi: 10.1158/0008-5472.CAN-13-2820
PMCID: PMC4134774
NIHMSID: NIHMS606705
PMID: 24938764
Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer
Stacey Meeker,1 Audrey Seamons,1 Jisun Paik,1 Piper M. Treuting,1 Thea Brabb,1 William M. Grady,2 andLillian Maggio-Price1
"One week after diet initiation, mice were inoculated with broth or H. bilis and were necropsied at several time points post-inoculation to assess inflammation, dysplasia, and neoplasia incidence. At 16 weeks post infection, 11% of mice fed high vitamin D diet had cancer compared to 41% of mice fed maintenance diet (p=0.0121). Evaluation at an early time point (1 week post-infection) showed that animals fed high vitamin D had decreased MAPK (p-p38 and p-JNK) activation in lamina propria leukocytes as well as decreased NFκB activation in colonic epithelial cells. Reduction in MAPK and NFκB activation correlated with decreased IBD scores (2.7 vs 15.5, p<0.0001) as well as decreased inflammatory cell infiltrates and reduced expression of proinflammatory cytokines in cecal tissue. These findings suggest that increased dietary vitamin D is beneficial in preventing inflammation-associated colon cancer through suppression of inflammatory responses during initiation of neoplasia or early stage carcinogenesis."
Cancer Res. Author manuscript; available in PMC 2015 Aug 15.
Published in final edited form as:
Cancer Res. 2014 Aug 15; 74(16): 4398–4408.
Published online 2014 Jun 17. doi: 10.1158/0008-5472.CAN-13-2820
PMCID: PMC4134774
NIHMSID: NIHMS606705
PMID: 24938764
Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer
Stacey Meeker,1 Audrey Seamons,1 Jisun Paik,1 Piper M. Treuting,1 Thea Brabb,1 William M. Grady,2 andLillian Maggio-Price1
"One week after diet initiation, mice were inoculated with broth or H. bilis and were necropsied at several time points post-inoculation to assess inflammation, dysplasia, and neoplasia incidence. At 16 weeks post infection, 11% of mice fed high vitamin D diet had cancer compared to 41% of mice fed maintenance diet (p=0.0121). Evaluation at an early time point (1 week post-infection) showed that animals fed high vitamin D had decreased MAPK (p-p38 and p-JNK) activation in lamina propria leukocytes as well as decreased NFκB activation in colonic epithelial cells. Reduction in MAPK and NFκB activation correlated with decreased IBD scores (2.7 vs 15.5, p<0.0001) as well as decreased inflammatory cell infiltrates and reduced expression of proinflammatory cytokines in cecal tissue. These findings suggest that increased dietary vitamin D is beneficial in preventing inflammation-associated colon cancer through suppression of inflammatory responses during initiation of neoplasia or early stage carcinogenesis."