Giraffe
Member
- Joined
- Jun 20, 2015
- Messages
- 3,730
My Vitamin D stays at 40 despite Supplementation of 50.000 IU per day.
I think that a vitamin D level at 40 ng/ml is quite OK.
I tried Magnesium but didnt feel like it did something
Whats the missing cofactor?
According to an article in German (link) it can happen that someone's vitamin D level is low because too much is converted to calcitriol (the active form). Several diseases and drugs can cause this. They mention:
- kidney disease
- diseases of the gall bladder or liver
- certain genetic disorders (e.g., a mutation of 1-a-hydroxylase)
- diseases of the parathyroid gland
- granulomatous diseases
- tumors
- taking certain medications (e.g., antiepileptic drugs)
- magnesium deficiency.
- Ravani, Pietro, et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney international, 2009, 75. Jg., Nr. 1, S. 88-95.
- Gonzalez, Esther A., et al. Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. American journal of nephrology, 2003, 24. Jg., Nr. 5, S. 503-510.
- Levin, A., et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney international, 2007, 71. Jg., Nr. 1, S. 31-38.
- Arteh, J., Narra, S., & Nair, S . Prevalence of vitamin D deficiency in chronic liver disease. Digestive diseases and sciences, 2010, 55. Jg., Nr. 9, S. 2624-2628.
- Long, R. G., et al. Serum-25-hydroxy-vitamin-D in untreated parenchymal and cholestatic liver disease. The Lancet, 1976, 308. Jg., Nr. 7987, S. 650-652.
- Jones, G., & Prosser, D. E. The activating enzymes of vitamin D metabolism (25-and 1a-hydroxylases). Vitamin D, 2011, 1. Jg., S. 23-42.
- Valdivielso, J. M., & Fernandez, E . Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta, 2006, 371. Jg., Nr. 1, S. 1-12.
- Silverberg, S. J. (2007), Vitamin D Deficiency and Primary Hyperparathyroidism. J Bone Miner Res, 22: V100–V104. doi: 10.1359/jbmr.07s202
- Grey A , Lucas J , Horne A , Gamble G , Davidson JS , Reid IR 2005 Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency. J Clin Endocrinol Metab 90:2122–2126
- Adams JS , Hewison M 2006 Hypercalcemia caused by granuloma-forming disorders. In: , Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th ed. Washington, DC: American Society for Bone and Mineral Research; 200–202
- Sharma, Om P. Hypercalcemia in granulomatous disorders: a clinical review. Current opinion in pulmonary medicine, 2000, 6. Jg., Nr. 5, S. 442-447.
- Hewison, M., Kantorovich, V., Liker, H. R., Van Herle, A. J., Cohan, P., Zehnder, D. and Adams, J. S. (2003), Vitamin D-Mediated Hypercalcemia in Lymphoma: Evidence for Hormone Production by Tumor-Adjacent Macrophages. J Bone Miner Res, 18: 579–582. doi: 10.1359/jbmr.2003.18.3.579
- Sweet R.A., et al. Vitamin D metabolite levels in oncogenic osteomalacia. Annals of internal medicine, 1980, 93. Jg., Nr. 2, S. 279-280.
- Noel Weidner. Review and Update: Oncogenic Osteomalacia-Rickets Ultrastructural Pathology 1991 15:4-5 , 317-333
- Niv, Y., Sperber, A. D., Figer, A., Igael, D., Shany, S., Fraser, G. and Schwartz, B. (1999), In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma. Cancer, 86: 391–397. doi: 10.1002/(SICI)1097-0142(19990801)86:3<391::AID-CNCR5>3.0.CO;2-A
- Collins, N., et al. A prospective study to evaluate the dose of vitamin D required to correct low 25-hydroxyvitamin D levels, calcium, and alkaline phosphatase in patients at risk of developing antiepileptic drug-induced osteomalacia. QJM, 1991, 78. Jg., Nr. 2, S. 113-122.
- Bouillion, Roger, et al. The effect of anticonvulsant therapy on serum levels of 25-hydroxy-vitamin D, calcium, and parathyroid hormone. The Journal of Clinical Endocrinology & Metabolism, 1975, 41. Jg., Nr. 6, S. 1130-1135.
- Zittermann, Armin. Magnesium deficit? overlooked cause of low vitamin D status?. BMC medicine, 2013, 11. Jg., Nr. 1, S. 229.
- Reddy V, Sivakumar B. Magnesium-dependent vitamin-D-resistant rickets. Lancet. 1974 May 18;1(7864):963-5. PubMed PMID: 4133647.