Vitamin D not increasing

[Giraffe]

My Vitamin D stays at 40 despite Supplementation of 50.000 IU per day.

I think that a vitamin D level at 40 ng/ml is quite OK.

I tried Magnesium but didnt feel like it did something
Whats the missing cofactor?

According to an article in German (link) it can happen that someone's vitamin D level is low because too much is converted to calcitriol (the active form). Several diseases and drugs can cause this. They mention:

- kidney disease
- diseases of the gall bladder or liver
- certain genetic disorders (e.g., a mutation of 1-a-hydroxylase)
- diseases of the parathyroid gland
- granulomatous diseases
- tumors
- taking certain medications (e.g., antiepileptic drugs)
- magnesium deficiency.

1. Ravani, Pietro, et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney international, 2009, 75. Jg., Nr. 1, S. 88-95.
2. Gonzalez, Esther A., et al. Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. American journal of nephrology, 2003, 24. Jg., Nr. 5, S. 503-510.
3. Levin, A., et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney international, 2007, 71. Jg., Nr. 1, S. 31-38.
4. Arteh, J., Narra, S., & Nair, S . Prevalence of vitamin D deficiency in chronic liver disease. Digestive diseases and sciences, 2010, 55. Jg., Nr. 9, S. 2624-2628.
5. Long, R. G., et al. Serum-25-hydroxy-vitamin-D in untreated parenchymal and cholestatic liver disease. The Lancet, 1976, 308. Jg., Nr. 7987, S. 650-652.
6. Jones, G., & Prosser, D. E. The activating enzymes of vitamin D metabolism (25-and 1a-hydroxylases). Vitamin D, 2011, 1. Jg., S. 23-42.
7. Valdivielso, J. M., & Fernandez, E . Vitamin D receptor polymorphisms and diseases. Clinica Chimica Acta, 2006, 371. Jg., Nr. 1, S. 1-12.
8. Silverberg, S. J. (2007), Vitamin D Deficiency and Primary Hyperparathyroidism. J Bone Miner Res, 22: V100–V104. doi: 10.1359/jbmr.07s202
9. Grey A , Lucas J , Horne A , Gamble G , Davidson JS , Reid IR 2005 Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency. J Clin Endocrinol Metab 90:2122–2126
10. Adams JS , Hewison M 2006 Hypercalcemia caused by granuloma-forming disorders. In: , Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th ed. Washington, DC: American Society for Bone and Mineral Research; 200–202
11. Sharma, Om P. Hypercalcemia in granulomatous disorders: a clinical review. Current opinion in pulmonary medicine, 2000, 6. Jg., Nr. 5, S. 442-447.
12. Hewison, M., Kantorovich, V., Liker, H. R., Van Herle, A. J., Cohan, P., Zehnder, D. and Adams, J. S. (2003), Vitamin D-Mediated Hypercalcemia in Lymphoma: Evidence for Hormone Production by Tumor-Adjacent Macrophages. J Bone Miner Res, 18: 579–582. doi: 10.1359/jbmr.2003.18.3.579
13. Sweet R.A., et al. Vitamin D metabolite levels in oncogenic osteomalacia. Annals of internal medicine, 1980, 93. Jg., Nr. 2, S. 279-280.
14. Noel Weidner. Review and Update: Oncogenic Osteomalacia-Rickets Ultrastructural Pathology 1991 15:4-5 , 317-333
15. Niv, Y., Sperber, A. D., Figer, A., Igael, D., Shany, S., Fraser, G. and Schwartz, B. (1999), In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma. Cancer, 86: 391–397. doi: 10.1002/(SICI)1097-0142(19990801)86:3<391::AID-CNCR5>3.0.CO;2-A
16. Collins, N., et al. A prospective study to evaluate the dose of vitamin D required to correct low 25-hydroxyvitamin D levels, calcium, and alkaline phosphatase in patients at risk of developing antiepileptic drug-induced osteomalacia. QJM, 1991, 78. Jg., Nr. 2, S. 113-122.
17. Bouillion, Roger, et al. The effect of anticonvulsant therapy on serum levels of 25-hydroxy-vitamin D, calcium, and parathyroid hormone. The Journal of Clinical Endocrinology & Metabolism, 1975, 41. Jg., Nr. 6, S. 1130-1135.
18. Zittermann, Armin. Magnesium deficit? overlooked cause of low vitamin D status?. BMC medicine, 2013, 11. Jg., Nr. 1, S. 229.
19. Reddy V, Sivakumar B. Magnesium-dependent vitamin-D-resistant rickets. Lancet. 1974 May 18;1(7864):963-5. PubMed PMID: 4133647.

 

[GTW]

Highlighting earlier reference statement:
High Vitamin D supplementation causes severe magnesium deficiency.
50,000 units is nothing but high.

 

[pondering]

Highlighting earlier reference statement:
High Vitamin D supplementation causes severe magnesium deficiency.
50,000 units is nothing but high.

This is very helpful to know. Do you think high vitamin D from sun can also cause magnesium deficiency?

 

[RPDiciple]

Highlighting earlier reference statement:
High Vitamin D supplementation causes severe magnesium deficiency.
50,000 units is nothing but high.

It does not

 

[GTW]

The claim was that high dose *supplementation with Vitamin D causes severe magnesium depletion.
Reading the whole report, achieving blood levels 50 and greater with D supplementation implies magnesium deficiency and with magnesium supplementation would not be possible.

 

[peter88]

I’ve never been able to raise vit d levels from the sun but taking a d3 supplement for a month fixed my level.

 

[Jonk]

I’ve never been able to raise vit d levels from the sun but taking a d3 supplement for a month fixed my level.

Same here but I also react pretty bad to sun exposure. Just heard Ray in an interview that he was able to stay out in the sun after supplementing vitamin D, so I'm hoping it will make a difference next summer.