Searching best supps/pharma for soft tissue calcification

[Candeias]

Cyproheptadine

Cyproheptadine Prevents / Reverses Soft Tissue Calcification

"Human equivalent dose was about 12mg daily, duration was just 4 days. Cyproheptadine prevented AND reversed soft tissue calcification by acting as an anti-heparin agent, which is similar to what vitamin K2 does.

EFFECT OF CYPROHEPTADINE ON A TOPICAL CALCIFICATION IN THE RAT - PubMed

""...In the rat, cyproheptadine prevents the soft-tissue calcification elicited by various mast-cell depletors at their subcutaneous injection site. This action does not appear to result from the anti-histaminic anti-serotonin properties of cyproheptadine, which showed in addition an in vitro anti-heparin effect.""
@haidut


Topic: Cyproheptadine And Vitamin D Seem To Go Very Well Together
@lampofred


Magnesium (and reduction of phosphorous)

Treatment of soft tissue calcifications with magnesium

Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats

Acute Induction of Soft Tissue Calcification with Transient Hyperphosphatemia in the KK Mouse by Modification in Dietary Contents of Calcium, Phosphorus, and Magnesium

"(...)Addition of magnesium or reduction of phosphorus in the diet completely prevented the development of all these changes(...)The present findings suggest that relative deficiency in magnesium is mainly responsible for the development."

Vitamin K

The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

"(...)Matrix Gla protein (MGP) is a major inhibitor of soft tissue calcification and contributes to preventing both intimal and medial vascular calcification. Vitamin K may also inhibit progression of vascular calcification by enhancing the activity of MGP through facilitating its γ-carboxylation."


Famotidine

Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo

"(...)Famotidine administration suppressed calcification in the Achilles tendon of ttw mice, a mouse model of ectopic ossification. These data suggest that famotidine inhibits osteogenic differentiation of tendon cells in vitro, and this inhibition may underlie the anti-calcification effects of the drug in vivo."


Famotidine Lowers PTH By Almost 50%


If you know of more accessible substances, please post.

 

[Logan-]

Vitamin D
Calcium
Thyroid
Salt
Vitamin K
Vitamin C
Magnesium

If you have low calcium intake, or low vitamin D, or have gut problems, you will experience calcification. Research “calcium paradox”.

 

[Candeias]

Vitamin D
Calcium
Thyroid
Salt
Vitamin K
Vitamin C
Magnesium

If you have low calcium intake, or low vitamin D, or have gut problems, you will suffer from that problem. Research “calcium paradox”.

Vitamin D can cause calcification very quickly, mainly due to its magnesium depletion (PTH can also be suppressed in this case).
"Excess" vitamin C turns into oxalate, creating kidney calcification.
Hyperthyroidism can also cause hypercalcemia.

 

[zorba990]

A little beyond me, but it appears the B12 has some action in relation to escorting calcium ions into the mitochondria:

Modulation of intracellular Ca(2+) concentration by vitamin B12 in rat thymocytes - PubMed

We have studied several novel effects of vitamin B12 (cyanocobalamin) on cellular Ca(2+) homeostasis in rat thymocytes. We determined the effect of various concentrations of vitamin B12 on intracellular Ca(2+) concentration ([Ca(2+)]i) and parameters of Ca(2+)in signaling using the fluorescent...

pubmed.ncbi.nlm.nih.gov

100 nM-10 mM B12 induced the accumulation of Ca(2+) in mitochondria. Somewhat higher concentrations of B12 (1-10 microM) had no effect on [Ca(2+)]i. A further increase in B12 concentration with range from 50 microM to 1 mM caused a dose-dependent elevation of [Ca(2+)]i from the basal level (115 +/- 5 nM) up to 200 +/- 50 nM in thymocytes, and this elevation was partially blocked in Ca(2+)-free media. This high concentration of vitamin B12 caused a gradual decrease of endoplasmic reticulum Ca(2+) stores by means of Ca-ATPase inhibition. The B12-induced increase in [Ca(2+)]i was not observed after depletion of intracellular Ca(2+) stores, induced by addition of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ), an inhibitor of endoplasmic reticulum Ca (2+)-ATPase, concanavalin A, or arachidonic acid. These studies show that vitamin B12 regulates [Ca(2+)]i via several different mechanisms at different B12 concentrations. Participation of G proteins and calmodulin activity in B12-mediated [Ca(2+)]i increase is discussed.

So this might, perhaps indicate that B12 deficiency could cause stagnation of calcium flow in some tissues, though concluding that would need more evidence. I do recall B12 being used for bursitis treatments long ago, but having difficulty finding the references.

 

[Candeias]

A little beyond me, but it appears the B12 has some action in relation to escorting calcium ions into

100 nM-10 mM B12 induced the accumulation of Ca(2+) in mitochondria. Somewhat higher concentrations of B12 (1-10 microM) had no effect on [Ca(2+)]i. A further increase in B12 concentration with range from 50 microM to 1 mM caused a dose-dependent elevation of [Ca(2+)]i from the basal level (115 +/- 5 nM) up to 200 +/- 50 nM in thymocytes, and this elevation was partially blocked in Ca(2+)-free media. This high concentration of vitamin B12 caused a gradual decrease of endoplasmic reticulum Ca(2+) stores by means of Ca-ATPase inhibition. The B12-induced increase in [Ca(2+)]i was not observed after depletion of intracellular Ca(2+) stores, induced by addition of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ), an inhibitor of endoplasmic reticulum Ca (2+)-ATPase, concanavalin A, or arachidonic acid. These studies show that vitamin B12 regulates [Ca(2+)]i via several different mechanisms at different B12 concentrations. Participation of G proteins and calmodulin activity in B12-mediated [Ca(2+)]i increase is discussed.

So this might, perhaps indicate that B12 deficiency could cause stagnation of calcium flow in some tissues, though concluding that would need more evidence. I do recall B12 being used for bursitis treatments long ago, but having difficulty finding the references.

Effects of vitamin B12 in culture medium for calcified nodule formation by rat dental pulp cells

I think it can redirect calcium to the places it should be.. but its a little beyond me too!

 

[ddjd]

vitamin d3 must be taken with magnesium, b6p5p and k2mk4 to work

 

[Candeias]

vitamin d3 must be taken with magnesium, b6p5p and k2mk4 to work

What dose of p5p? p5p causes a decrease in B12 very quickly.

 

[S.Holmes]

Bump

 

[liam183]

Vitamin K2 mk-4 all day everyday.

 

[tasfarelel]

I wonder if ketotifen also works in this direction as it is a powerful mast cell stabilizer and has also some anti serotonin effects. This was already asked in the thread by @haidut with no answer.

 

[Validus]

I would say high dose vitamin k2 mk-7 and high dose nattokinase, serrapeptase and lumbrokinase.

I would also check your ApoB levels and reduce them as much as possible.

Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular

www.ncbi.nlm.nih.gov

"Vitamin K2 as MK-7 is unique because it impacts arterial calcification, and no other compound (drug or vitamin) has been shown to do this."

 

[TheSir]

Potassium and sodium are the solvents that keep calcium out of extracellular tissue. Their levels are modulated by thyroid and adrenal activity. The more active these glands are, the less calcification there will be.

 

[Razvan]

Ciproheptadine is amazing for that, but only in high enough dosages.

 

[Candeias]

Ciproheptadine is amazing for that, but only in high enough dosages.

Do you have any experience or studies with dosages that can confirm this?

 

[Candeias]

Vitamin K2 mk-4 all day everyday.

I would say high dose vitamin k2 mk-7 and high dose nattokinase, serrapeptase and lumbrokinase.

I would also check your ApoB levels and reduce them as much as possible.

Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular

www.ncbi.nlm.nih.gov

"Vitamin K2 as MK-7 is unique because it impacts arterial calcification, and no other compound (drug or vitamin) has been shown to do this."

From my research on people's reports, the mk7 has actually more descaling capacity than the mk4, someone correct me if I'm wrong

 

[Razvan]

Do you have any experience or studies with dosages that can confirm this?

Yes, i have experience with it. It made me grow very small amounts of hair follicles near the tamples and made my hair generally grow much faster, also stopped my flaky scalp.
All of these which i correlated with the decalcification effect, i was talking also sodium bicarbonate and magnesium carbonate every day with it. I wasnt taking it for that, just noticed these extra effects after a period.
Dosage range from 8mg to 20mg.

 

[Regina]

kuinone!!!