Methylene Blue Inhibits Fatty Acid Oxidation And Improve Metabolic Flexibility In The Heart

Hans

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Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart
"Our results also indicate that decreased lysine acetylation of FA oxidation enzymes with MB treatment positively correlates with a decrease in the overall FA β-oxidation pathway, suggesting a protective effect of this compound on the excessive reliance of the heart on FA oxidation in diabetes."

It does so by lower the activity of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase enzyme.

The dose was 10mg/kg in the rats, which would be about 1.43mg/kg in humans. It's a bit high dose, but methylene blue accumulates in the mitochondria and could possibly be achieved by long term use at smaller doses.
 
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