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Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart
"Our results also indicate that decreased lysine acetylation of FA oxidation enzymes with MB treatment positively correlates with a decrease in the overall FA β-oxidation pathway, suggesting a protective effect of this compound on the excessive reliance of the heart on FA oxidation in diabetes."
It does so by lower the activity of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase enzyme.
The dose was 10mg/kg in the rats, which would be about 1.43mg/kg in humans. It's a bit high dose, but methylene blue accumulates in the mitochondria and could possibly be achieved by long term use at smaller doses.
"Our results also indicate that decreased lysine acetylation of FA oxidation enzymes with MB treatment positively correlates with a decrease in the overall FA β-oxidation pathway, suggesting a protective effect of this compound on the excessive reliance of the heart on FA oxidation in diabetes."
It does so by lower the activity of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase enzyme.
The dose was 10mg/kg in the rats, which would be about 1.43mg/kg in humans. It's a bit high dose, but methylene blue accumulates in the mitochondria and could possibly be achieved by long term use at smaller doses.
