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Peater Piper
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- Mar 18, 2016
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The author's actually mentioned the liver. They didn't think NAFLD would have set in yet, but didn't actually perform any tests. However. the relatives of the diabetics responded similarly to the controls when tested with a high carbohydrate meal. I would have expected either increased glucose due to the liver not shutting down gluconeogenesis, or elevated insulin, if the liver is starting to fatten up.I think one of the problems with this contradiction you are seeing is that people often report the actions in the whole body, in a specific tissue (like liver), or in a cellular preparation, as the same. As we all know, muscle burns more fatty acids at rest than liver or the brain, and how they are affected by substrate availability and the hormonal signals is different as well. So at the whole body level, what you describe could be the effect and that is confusing. It's still possible, however, that the livers of those prediabetic people are having trouble using glucose, and that could be balanced out by muscle burning more glucose than fat compared to the healthy individuals. I think what the liver does (or doesn't do) is probably the most important for diabetic symptoms.