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Human Study Confirms Alzheimer As A Metabolic Condition (brain Diabetes)

Discussion in 'Scientific Studies' started by haidut, Oct 19, 2017.

  1. haidut

    haidut Member

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    Over the last 3 years I posted quite a few studies on Alzheimer disease (AD) and have discussed it at length in the Danny Roddy podcasts. Among the most successful interventions are niacinamide and methylene blue (MB) both of which are in human clinical trials, thyroid and aspirin.
    Alzheimer Disease (AD) Is Likely A Metabolic Disorder
    Glucose Deprivation In The Brain Is A Causative Factor In Alzheimer's Dieases (AD)
    Delirium (and Dementia/AD) Is Caused By Inability To Oxidize Glucose
    Blocking PUFA Metabolism May Reverse Alzheimer Disease (AD)
    Another Study Links PUFA To Alzheimer Disease (AD)
    Salicylate For Alzheimers (Aspirin)
    Methylene Blue Fail Alzhemiers Trial - (No It Didn't)


    In a new and very important study that looks like it has been written by Peat himself (except for the estrogen part), scientists have finally provided solid human evidence that AD is a metabolic condition characterized by the inability to oxidize sugar. For women, apparently the adverse changes likely begin pre-menopause with signs of hypometabolism evident even in their early 40s.
    What is particularly disturbing about this study is the complete inability of scientist to make the link between high estrogen and the induction of "starvation mode" in brain metabolism which they found in AD patients. Estrogen does this by directly increasing fatty acid oxidation and blocking glucose oxidation through the well-known Randle cycle (The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise. - PubMed - NCBI). In fact, no other hormone is known to cause this "shock state" change in metabolism, not even cortisol or adrenaline. I suppose the mantra "estrogen is low in menopause" is just too sacred for any scientist to publicly challenge...
    At the very least this study should serve as evidence that the stress reaction (and its mediators estrogen, serotonin, cortisol, adrenaline, prolactin, growth hormone, NO and endorphins) is not something that should be left unopposed and the chronic rise in fatty acid oxidation is anything but benign.

    Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery
    Menopause triggers changes in brain that may promote Alzheimer’s | Cornell Chronicle
    "...The tests revealed the women who had undergone menopause or were peri-menopausal had markedly lower levels of glucose metabolism in several key brain regions than those who were pre-menopausal. Scientists in prior studies have seen a similar pattern of “hypometabolism” in the brains of patients in the earliest stages of Alzheimer’s – and even in mice that model the disease. In addition, menopausal and peri-menopausal patients showed lower levels of activity for an important metabolic enzyme called mitochondrial cytochrome oxidase, as well as lower scores on standard memory tests. The strong contrast with pre-menopausal patients remained even when accounting that the menopausal and peri-menopausal women were older."

    "...More specifically, the authors suggest that the menopausal fall in estrogen may trigger a shift to a “starvation reaction” in brain cells – a metabolic state that is beneficial in the short term but can be harmful in the long term."
     
  2. paymanz

    paymanz Member

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    Thanks haidut,

    Is there any reference showing estrogen increases FFA level?

    Of curse if you meant it with this:
     
  3. paymanz

    paymanz Member

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  4. OP
    haidut

    haidut Member

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    There is a TON. Have you searched Pubmed or Google? Peat has also mentioned it in pretty much every article where he mentioned estrogen. Here are two studies. The second one is especially damning as it shows directly the glucose blocking effects of estrogen through the Randle cycle.
    Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats. - PubMed - NCBI
    The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise. - PubMed - NCBI
     
  5. paymanz

    paymanz Member

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    I especially want know about FFA level correlation with estrogen.

    I was under the impression that FFA level is biggest factor affecting randle cycle.

    Some studies show higher FFA with estrogen deficiency. Maybe estrogen lowers FFA level by stimulating beta oxidation?
     
  6. OP
    haidut

    haidut Member

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    Did you read the second study??
     
  7. paymanz

    paymanz Member

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    Yes ,thank you , I read it now. I was on a phone so I didn't read it at first,sorry.

    But there is mixed studies, especially in case of subcutaneous fat tissue, estrogen inhibits lipolysis here.according to some studies.
     
  8. Fractality

    Fractality Member

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    What about other neurodegenerative diseases like progressive supranuclear palsy? My father was diagnosed with this and the behavioral symptoms are similar to Alzheimer's, so there could be parallels. My father's rapid deterioration was preceded by excessive exercise which of course raises free fatty acids.
     
  9. OP
    haidut

    haidut Member

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    Excessive fatty acids release has been so far confirmed in every chronic disease. So lowering them should be beneficial. I would try niacinamide and aspirin, especially since niacinamide's recent trials with Huntington, Duchenne dystrophy, Myasthenia gravis, etc.
     
  10. danishispsychic

    danishispsychic Member

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    i think the first thing to think about it Alz is that is more of a syndrome than a disease. im sure a lot of people would not agree- but there are so many versions of dementia and many roads that lead to what is currently called Alz. one day, i bet that all of Ray Peats work will be used in the prevention and treatment and of course Big Pharma will try to find a way to make it their idea , as they always do . also i dont think you can rule out the DNA of it all either, the genetic markers and variants matter- but what you do about them matters more. also- it matters what crap vaccines you are pumped full of, how much metal you have/ had in your teeth and how about aspartame? how about whole generations that are gluten intolerant and dont know it- and it blocks all their b12 and what THAT does to the brain/gut ? the one doctor that tested my pregnegolone levels ( yay him and it was super low ) told me that anyone over 50 should be putting it in there morning smoothie, it is THAT important for the brain and hormones. interesting that my mother was diagnosed Alz and grew up in the depression. she told me that many days they had nothing to eat and had to pick potatoes on the side of the road to have ANY food.... starvation cannot help the situation. How about all the women who took those terrible fertility DES shots in the 60s? I am a DES daughter so naturally i am estrogen dominant.... it is a WHOLE thing. so many factors at work here .
     
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