ImprovingDaily
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- Joined
- Jan 4, 2017
- Messages
- 278
I've seen some negative things said about thc and cannabis in general, when it comes to being peaty. Any idea how CBD stacks up in the peat world?
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You're welcome. I looked it up recently because so many people are promoting it as a panacea.Awesome. Thanks!
You're welcome. I looked it up recently because so many people are promoting it as a panacea.
400mg is A LOT. I suspect placebo too. Its much milder than THC, but to feel nothing at all on that dose would surprise me.I just got dosed 400mg orally today as part of a clinical trial run by The Victorian State Government. Felt nothing. Maybe I got placebo lol.
400mg is A LOT. I suspect placebo too. Its much milder than THC, but to feel nothing at all on that dose would surprise me.
Yeah. For reference, cannabis is legal where I live. Most doses--THC or CBD--are in the 5-10mg range. Plenty of people will do 2-4 doses at a time, but still a lot less. CBD in 5-10 mg reduces pain, relaxes muscles, gives a sense or relaxation and calm. Not at all unpleasant. I don't think a dose of 400mg would have a long term neg affect. In fact, in terms of acute response it seems impossible to overdose in practical terms.I ended up noticing potent sluggishness, anhedonia, reduced mood and motivation 2 hours after the dose. I also noticed intense dizziness and light-headedness. I think it was definitely real. 400mg was a lot.
Great stuff. In my experience it has no negative effects on libido. At least not occasional moderate doses.http://www.theroc.us/researchlibrary/Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol- A Chemical Compound of Cannabis sativa.pdf
Here's an interesting review on the anxiolytic and antidepressant effect of CBD in rats. In general it appears to be anxiolytic and perhaps antidepressant. Most substances that generate those effects in general usually affect sexual function (SSRI's, Benzodiazepines). The paper does give off the vibe that CBD is a great substance with no negative effects, so I take these results with caution.
Also the doses used were anywhere from 2.5 to 20 mg/kg in rats. I don't know how that corresponds to humans, but if were to use the same dosage for humans, that is anywhere from 175mg to 1400mg for a 70kg human.
I think it's potentially a useful substance to have for those who face inescapable stress for social situations, performance anxiety, etc.... but probably shouldn't be used as a daily crutch. The paper mentioned near the end how cannabinoids modulate serotonergic neurotransmission, but does not elaborate on those effects. If CBD lowered cranial serotonin, then CBD would most definitely be Peaty.
I've experimented with CBD a little and I'm pretty sure all its essentially doing is raising nitric oxide. This explains the relaxation, vasodilation and other benefits people attest to it's "magical" effect.I've seen some negative things said about thc and cannabis in general, when it comes to being peaty. Any idea how CBD stacks up in the peat world?
I've experimented with CBD a little and I'm pretty sure all its essentially doing is raising nitric oxide. This explains the relaxation, vasodilation and other benefits people attest to it's "magical" effect.
As we know from peat, long term, high nitric oxide is very destructive
Thanks for sharing.Ray Peat email response regarding CBD:
It can probably be helpful for lowering nitric oxide in some situations, but there’s some evidence that it increases prostaglandins, which could be harmful in a person whose tissues have a lot of PUFA. The acidic form, CBDA, seems likely to be more broadly protective.