• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

High-dose Vitamin K2 Supplementation

Lucy

Member
Joined
Oct 29, 2012
Messages
70
Ray gave me several recommendations lately, for myself and my parents, that included a high-dose vitamin K supplementation. He said vitamin K could help with blood pressure reduction, building bone density, mental clarity, and he also recommended it as an anti-estrogen agent (against cancer and for prolactin reduction). The amounts he mentioned were quite high, 15 mg and 40 mg daily.

Does anyone here have experience with supplementing higher amounts of vitamin K?
 

kiran

Member
Joined
Aug 9, 2012
Messages
1,054
I've done 15mg MK4 x3 daily, before Ray Peat. IIRC it caused a temporary crash as calcium levels dropped instantly, but then in a bit I felt better.

So perhaps you should take some calcium with it?
 

tomisonbottom

Member
Joined
Apr 17, 2013
Messages
907
Hi Lucy,

Did you end up doing the High K supplementation then?
If so, how did it effect you?
 

firelion

New Member
Joined
May 11, 2014
Messages
1
How do you know that mk4 depleted your calcium levels, did you have them checked?

I've been taking 15mg of mk4 daily, without any Vitamin D supplementation. Does anyone know if this would have a negative effect?
 

yoshiesque

Member
Joined
Mar 9, 2014
Messages
365
Lucy said:
Ray gave me several recommendations lately, for myself and my parents, that included a high-dose vitamin K supplementation. He said vitamin K could help with blood pressure reduction, building bone density, mental clarity, and he also recommended it as an anti-estrogen agent (against cancer and for prolactin reduction). The amounts he mentioned were quite high, 15 mg and 40 mg daily.

Does anyone here have experience with supplementing higher amounts of vitamin K?


Can you please explain to me why he gave these recommendations for you and your family? Was there a current health issue/genetic issue that was at play, in order for him to give this to you?

THanks!
 

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
The thing about K2 is that it can cause an imbalance of the salts -- Calcium, Magnesium, Potassium, etc. If I were supplementing that high I would probably do a reboot of my diet and watch for signs of imbalance or depletion. Muscle aches and twitches are a sure sign of Mg deficiency, and you get charlie horses and cramps if you are low on potassium. Low calcium will crash your thyroid and possibly bring your blood pressure too high or low.

If you're going to supplement that much just keep an eye on it day to day.
 

HDD

Member
Joined
Nov 1, 2012
Messages
2,042
messtafarian said:
The thing about K2 is that it can cause an imbalance of the salts -- Calcium, Magnesium, Potassium, etc. If I were supplementing that high I would probably do a reboot of my diet and watch for signs of imbalance or depletion. Muscle aches and twitches are a sure sign of Mg deficiency, and you get charlie horses and cramps if you are low on potassium. Low calcium will crash your thyroid and possibly bring your blood pressure too high or low.

If you're going to supplement that much just keep an eye on it day to day.

That's interesting, messtafarian, I always thought my charlie horses were magnesium related.
 

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
HDD said:
messtafarian said:
The thing about K2 is that it can cause an imbalance of the salts -- Calcium, Magnesium, Potassium, etc. If I were supplementing that high I would probably do a reboot of my diet and watch for signs of imbalance or depletion. Muscle aches and twitches are a sure sign of Mg deficiency, and you get charlie horses and cramps if you are low on potassium. Low calcium will crash your thyroid and possibly bring your blood pressure too high or low.

If you're going to supplement that much just keep an eye on it day to day.

That's interesting, messtafarian, I always thought my charlie horses were magnesium related.

In my experience, as an ex-lowcarb dieter and thyroid problem person, potassium and magnesium deficiencies "feel" different. Mg is a clear muscle tug, twitch, tremor or spasm; potassium feels more arthritic and achy.
 

Peata

Member
Joined
Jun 12, 2013
Messages
3,402
I'm taking 15 mg. day for about a week. I am not certain of the effects yet. I do feel a little ache sometimes in my rib where I fractured it 1.5 year ago. I don't know if K2 is doing something there. I can't think of anything that could be causing me to feel a sensation there -no coughing, straining, etc. I'll keep an eye on it.
 

Amazoniac

Member
Joined
Sep 10, 2014
Messages
8,586
Location
Not Uganda
The menaquinone content in milch is mainly menatetrenone, it's clearance is rapid.
Zeus belives that there are active metabolites despite its disapperance.
Babyzords consume them spread throughout the day and the milch isn't skimmed.
Undigested plant material in the colon should supply adults with a steady stream of vit K to cover most if not all needs.
In that sense, there would be no signal for adapting to an ample.. reservoir. Which is what we find in ruminant liver. In other words, a steady supply is needed.
Transdermal absorption is steadier, but I think that with either route it's best to spread the doses.

Some people drink skim milch, don't eat greens, have gut problems and take a single 15mg load of mk4. Diokine, Travisord and Westside probably disapprove the combination. If so, I join the choir.

And yes, I miss Such's posts.
 

Makrosky

Member
Joined
Oct 5, 2014
Messages
3,570
I had really wonderful results with high dose K2 supplementation but after a few days I crashed badly probably due to calcium/potassium deficiency. I had pain in my tendons/ligaments/TMJ.
 

omnivoracious

Member
Joined
Aug 1, 2017
Messages
51
I've been taking a supplement that has 25mg of MK4. I didn't intent to take such a high dose, I just like the fact the supplement has K1, MK4 and MK7. It also contains Astaxanthin. No real issues as far as I can tell, I had my cholesterol measured last month and it was 194. The small LDL-P is elevated and it states plainly on the Vit K bottle that the supplement can result in an increase in the diameter and number of LDL so what I will probably do is dial down the dosage and see if that gets the small LDL-P to drop down to the normal range. I did a calcium scan about a year and half ago and got a totally clean bill of health and will probably test it again this month just to make sure everything looks good and if that's the case I'll go down to a lower dose and see how that impacts small LDL-P.
 

rw39

Member
Joined
Dec 1, 2015
Messages
62
I've been taking a supplement that has 25mg of MK4. I didn't intent to take such a high dose, I just like the fact the supplement has K1, MK4 and MK7. It also contains Astaxanthin. No real issues as far as I can tell, I had my cholesterol measured last month and it was 194. The small LDL-P is elevated and it states plainly on the Vit K bottle that the supplement can result in an increase in the diameter and number of LDL so what I will probably do is dial down the dosage and see if that gets the small LDL-P to drop down to the normal range. I did a calcium scan about a year and half ago and got a totally clean bill of health and will probably test it again this month just to make sure everything looks good and if that's the case I'll go down to a lower dose and see how that impacts small LDL-P.

What’s the name and brand of this supplement?
 

Amazoniac

Member
Joined
Sep 10, 2014
Messages
8,586
Location
Not Uganda
No, you can't really overdose on mk4, but no need to take more than 1-2mg (from what I've read), to be honest. Unless you're treating a condition.
That's also what people who supplement vit C in megadoses claim. Just because they're safe in great amounts, doesn't mean that those won't come with negative effects. I respect you regardless of your current version.
 
Last edited:

Tom2.0

Member
Joined
Feb 3, 2018
Messages
8
That's also what people who supplement vit C in megadoses claim. Just because they're safe in great amounts, doesn't mean that those won't come with negative effects. I respect you regardless of your current version.

Well let me reiterate, there are those who take a pharmacological dose of 45 mg/d, which is the dose that has been used to treat osteoporosis. But is anyone really foolish enough to take a megadose of mk4 with the intent to cause harm to one's self? Most mk4 supplements are in the low range of 0.2 - 2mg, even taking 2mg 3 times a day won't cause anything.
 

Similar threads

Top