Study Unlocks Which Form Of K2 Has Higher Bioavailability


The Law & Order Admin
Jan 4, 2012
USA ... mobile=off

Study Unlocks Which Form of K2 Has Higher Bioavailability
November 27, 2012

Consuming vitamin K2 in its MK-7 form is better for raising levels of the vitamin in serum than K2 in the MK-4 form, says a new study from Japan and the Netherlands.

The results indicate that the "nutritional values of vitamin K2 homologues should be differentiated with regard to bioavailability and efficacy," wrote scientists from Maastricht University in The Netherlands and Kagawa Nutrition University in Japan in the Nutrition Journal.

There are two main forms of vitamin K: phylloquinone, also known as phytonadione (vitamin K1), which is found in green leafy vegetables such as lettuce, broccoli and spinach and makes up about 90% of the vitamin K in a typical Western diet; and menaquinones (vitamin K2), which make up about 10% of Western vitamin K consumption and can be synthesized in the gut by microflora.

Menaquinones (MK-n: with the n determined by the number of prenyl side chains) can also be found in the diet; MK-4 can be found in animal meat, MK-7, MK-8 and MK-9 are found in fermented food products like cheese, and natto is also a rich source of MK-7.

"Because all vitamin K homologues can be converted to MK-4 in vivo, MK-4 is considered to have specific functions other than gamma-carboxylation of vitamin K-dependent proteins," explained the researchers.

"In this study, we demonstrated that a nutritional dose of MK-7 is well absorbed in humans, and significantly increases serum MK-7 levels, whereas MK-4 had no effect on serum MK-4 levels."

The researchers tested the effects of a single dose of MK-4 (420 mcg) or MK-7 (420 mcg) consumed with a standardized breakfast in 10 healthy Japanese women. Results showed that MK-7 was well absorbed and was measurable in serum samples up to two days after consumption. MK-4 was not detectable in serum.

A second study that used consecutive administration of MK-4 (60 mcg) or MK-7 (60 mcg) for seven days again with 10 healthy Japanese women indicated again that MK-4 did not increase MK-4 levels. On the other hand, MK-7 was found to increase MK-7 levels.

"The current study shows that MK-4 has a poor bioavailability at a nutritional level dose, whereas MK-7 is well absorbed and detectable in the blood at nutritional levels," the researchers wrote.

"In a previous rat study from our group, the intake of a nutritional dose of MK-4 did not increase the MK-4 levels in extrahepatic tissues, whereas MK-7 significantly increased MK-4 in extrahepatic tissues," they added. "Thus, MK-7 is a better supplier for MK-4 in vivo than MK-4 itself."

Nutrition Journal 11(1):93, 2012


therefore, the opposite is true? (happens often in medical studies)
Last edited by a moderator:


Aug 9, 2012
That is kinda interesting. I guess this is why Ray recommends Super-K, because it's not entirely clear which one will turn out to be better overall.
Last edited by a moderator:


Nov 25, 2012
One potential issue is that all of the commercial K2 MK7 I've been able to find is soy (Natto) derived, and hence may have phytoestrogenic effects.

I wish we knew what the "standardized breakfast" is. I know for certain at least the MK4 is fat soluble and should be taken with a fat-containing meal. The Thorne MK4 is sold as a solution in MCT oil.
Last edited by a moderator:


Nov 26, 2012

When I asked Peat which supplement will be good for my crohn's (beside thyroid) he told me that either Carlson or life extension's vitamin K should be good.
So, like you said, super K is a mixed of K1 and K2 from mk4 and mk7 but Carlson is only mk4.
And, so far, I don't know what to pick so I rotate between the two....
Last edited by a moderator:
Similar threads
Thread starter Title Forum Replies Date
GorillaHead Is this study about vitamin A most likely a lie to protect the use of isotretinoin? Skin 0
Rick K Interesting study in curing cancer Cancer 3
B Ray Peat KMUD Vaccinations, study of villages info? Interviews 5
F DANGER! DANGER! Fauci is running the study that will show whether or not the vaccines stop transmission! Breaking News 1
A Huge Ivermectin study that showed massive positive results against COVID was totally faked. Scientific Studies 20
Mito Children Should Not Be Forced To Wear Masks Due To CO2 Levels, New Study Suggests Miscellaneous Health Discussions 1
S Ageing process is unstoppable, finds unprecedented study Ask For Help or Advice 24
charlie The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study Scientific Studies 8
Hgreen56 Ray said: "animals on coconut oil got lean". this study say the opposite? Coconut Oil 3
G PFA's Toxic ‘forever chemicals’ widespread in top makeup brands, study finds Thyroid and Hormones 7
md_a First case of postmortem study in a patient vaccinated against SARS-CoV-2 Scientific Studies 125
Mito For men, low testosterone means high risk of severe COVID-19, study suggests Miscellaneous Health Discussions 0
G Looking for study on gamma ray, frogs, red light Radiation 2
miles Stillbirth risks higher with Covid according to study Ask For Help or Advice 8
GorillaHead According to this study the androgen receptor is basically repressed Hair & Nails 1
miles New Study From Harvard Shows “Systemic” Presence of Spike Proteins in Blood Following Vaccination Vaccines 7
D Cowan and Kaufman on Lanka's recent study - pathogenic viruses never isolated and purified Viruses, Parasites, Fungus, Vaccines 4
VendettaRed911 What do you guys make of this study -- Wellbutrin? Supplements, Pharmaceutical Drugs 4
D Alternatives to radiography for motility study Digestion 0
R Bullied youths are much more likely to have violent fantasies, new study shows Scientific Studies 1
V Marine PUFAs linked to lower mortality (Study) Polyunsaturated Fats, Seed Oils 4
haidut MIT Study: Social distancing, occupancy limits likely useless Health 30
P Study: Vitamin A theory of vaccine injury Scientific Studies 26
D Link between depression/obesity and PUFA in this study? Polyunsaturated Fats, Seed Oils 0
A Study says low serotonin causes mice and rabbits to become gay Scientific Studies 3
Mito A third of COVID survivors suffer neurological or mental disorders: study Miscellaneous Health Discussions 20
J Study: Excessive ingestion of honey has long lasting feminization tendency. Sugar, Honey 23
D Study: Lithium Is As Effective For ADHD As Methylphenidate Articles & Scientific Studies 20
Lizb Ferret study - mRNA Animals 3
Philomath Need help debunking or confirming- Study claims reduction in cognitive performance due to wearing masks, and their increase in CO2. Scientific Studies 27
charlie CDC: Face Masks Don’t Prevent COVID-19, Study Finds Masks Have Negligible Impact On Coronavirus Numbers Articles & Scientific Studies 14
Drareg German Study: Laboratory Accident Most Likely Cause of Coronavirus Pandemic Society 38
AlexR Teflon "Forever Chemical" Detox Through Phlebotomy Study Science 6
charlie An Open-Label Pilot Study With High-Dose Thiamine in Parkinson's Disease Scientific Studies 5
ddjd New Study By Dr. Steven Quay Concludes that SARS-CoV-2 Came from a Laboratory Ask For Help or Advice 3
S The SECAR study: Sodium selenite reverses chemotherapy resistance Cancer 5
I 2015 Study ; Beverage Hydration Index Scientific Studies 4
I Study Showing Mitochondria moving between cells Scientific Studies 0
Hgreen56 Anti-Peat Study reveals how sugars wipe out important bacteria in gut Debate - Anti-Peat 17
I 2008 Study ; Comparison of lipid and fatty acid profiles of commercially raised pigs with laboratory pigs and wild-ranging warthogs Scientific Studies 0
ecstatichamster Can you Debunk this asymptomatic spreader study on an airplane Articles & Scientific Studies 9
ecstatichamster Yet another stupid asymptomatic spread Covid study Articles & Scientific Studies 8
jpgio Interesting study claims Vitamin K2 should be classified as a hormone Supplements, Pharmaceutical Drugs 9
ecstatichamster asymptomatic spreaders - a fake study? Scientific Studies 3
Mauritio Autism Study Suggests Connection Between Repetitive Behaviors And Gut Problems Scientific Studies 9
Drareg COVID T CELL Study In The UK Articles & Scientific Studies 10
A Exploratory Controlled Study Of The Migraine-Suppressing Effects Of Psilocybin Articles & Scientific Studies 2
H A Cross-sectional Study Of Plasma Trace Elements And Vitamins Content In Androgenetic Alopecia In Me Articles & Scientific Studies 0
ecstatichamster Study Shows Lockdowns Cause More Infection Than Not Scientific Studies 3
Gadreel Has Anyone Else Heard Of A 8 Wk 400mg Dhea Study? Supplements, Pharmaceutical Drugs 24

Similar threads