orewashin
Member
- Joined
- Jun 16, 2020
- Messages
- 327
CFS is probably caused by midbrain damage, causing failure to heal the brain and body after exertion-induced injury. There's evidence for midbrain regression and prefrontal compensation.
Taking it easy (letting the midbrain heal and NOT using the prefrontal areas) seems conductive to healing.
Caffeine probably reduces its healing. I find it acts like a type of exertion and causes fatigue afterward.
I wonder about thyroid. I sleep better from T3 and feel better psychiatrically. My body turns T4 into reverse-T3 or something and I get the opposite effect of T3. The body reduces T3 during injury, infection, starvation, etc. What if the low-T3 syndrome is actually adaptive in this case? People with CFS have a higher incidence of low-T3 syndrome.
Pregnenlolone and progesterone don't cross the BBB, IIRC. It's T3 that turns cholesterol into these hormones in the brain, which is why it may aid mylelination of the midbrain and heal it.
Recently, RP said that the body has an adaptive fasting response, in times of infection, for example. I have a chronic lack of appetite, does it mean I shouldn't eat?
Even serotonin in this case seems protective. If the prefrontal areas are activated due to a low-serotonin state, then it could slow healing.
Taurine and niacinamide may be useful in this case for inhibiting the cortex. CO2 and sodium the same. I found that sodium reduces muscle pain. Gelatin could also be good.
What if red light promotes healing of the midbrain, but light in general puts strain on the system, thus why people sometimes avoid light? People with CFS are prone to overstimulation from noise, light, etc.
People with CFS have a reduced inflammatory response to injury. What kind of effect would aspirin have if a person doesn't even have an issue with inflammation? Would it be useless?
Normal Peaty advice doesn't seem to apply in the case of CFS, and it's resistant to stuff like PUFA restriction. PUFAs cause an inflammatory state, impairing healing, but people with CFS aren't effected by inflammation, rather a lack of proper inflammation.
Sources:
Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression
Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome
Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study
A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis
Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome - PubMed
Intra brainstem connectivity is impaired in chronic fatigue syndrome - PubMed
A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques - PubMed
Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans - PubMed
Taking it easy (letting the midbrain heal and NOT using the prefrontal areas) seems conductive to healing.
Caffeine probably reduces its healing. I find it acts like a type of exertion and causes fatigue afterward.
I wonder about thyroid. I sleep better from T3 and feel better psychiatrically. My body turns T4 into reverse-T3 or something and I get the opposite effect of T3. The body reduces T3 during injury, infection, starvation, etc. What if the low-T3 syndrome is actually adaptive in this case? People with CFS have a higher incidence of low-T3 syndrome.
Pregnenlolone and progesterone don't cross the BBB, IIRC. It's T3 that turns cholesterol into these hormones in the brain, which is why it may aid mylelination of the midbrain and heal it.
Recently, RP said that the body has an adaptive fasting response, in times of infection, for example. I have a chronic lack of appetite, does it mean I shouldn't eat?
Even serotonin in this case seems protective. If the prefrontal areas are activated due to a low-serotonin state, then it could slow healing.
Taurine and niacinamide may be useful in this case for inhibiting the cortex. CO2 and sodium the same. I found that sodium reduces muscle pain. Gelatin could also be good.
What if red light promotes healing of the midbrain, but light in general puts strain on the system, thus why people sometimes avoid light? People with CFS are prone to overstimulation from noise, light, etc.
People with CFS have a reduced inflammatory response to injury. What kind of effect would aspirin have if a person doesn't even have an issue with inflammation? Would it be useless?
Normal Peaty advice doesn't seem to apply in the case of CFS, and it's resistant to stuff like PUFA restriction. PUFAs cause an inflammatory state, impairing healing, but people with CFS aren't effected by inflammation, rather a lack of proper inflammation.
Sources:
Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression
Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome
Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome: A Case–Control Study
A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis
Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome - PubMed
Intra brainstem connectivity is impaired in chronic fatigue syndrome - PubMed
A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques - PubMed
Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans - PubMed