Thiamine (Vitamin B1) And Fatigue In Inflammatory Bowel Diseases

charlie

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Results: Ten patients out of twelve showed complete regression of fatigue, while the remaining two patients showed nearly complete regression of fatigue compared to the chronic fatigue syndrome scale scores before therapy.

Conclusions: The absence of blood thiamine deficiency and the efficacy of high-dose thiamine in our patients suggest that fatigue is the manifestation of a thiamine deficiency, likely due to a dysfunction of the active transport of thiamine inside the cells, or due to structural enzymatic abnormalities. The administration of large quantities of thiamine increases the concentration in the blood to levels in which the passive transport restores the normal glucose metabolism in all cells and leads to a complete regression of fatigue.

More at link: Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study - PubMed
 

Maljam

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"Depending upon the body weight of each patient, dosage ranged from 600 mg/day (60 kg) to 1,500 mg/day (90 kg)."

Just adding this part in case the study ever disappears for some reason!
 

S-VV

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I think it's becoming more clear that very high dose thiamine (even the plain HCl) has powerful effects on the CNS
 

charlie

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"Depending upon the body weight of each patient, dosage ranged from 600 mg/day (60 kg) to 1,500 mg/day (90 kg)."

Just adding this part in case the study ever disappears for some reason!
Good call!

Another important part is blood Thiamine levels can test normal while still having a deficiency. Even people with Wieneke's Encephalitis can show normal blood levels of Thiamine. Simply put, the typical Thiamine blood tests to look for deficiency is almost useless.

"Fatigue was measured using the chronic fatigue syndrome scale, and the determination of thiamine and thiamine pyrophosphate levels in the blood was carried out through blood tests. The levels of thiamine and thiamine pyrophosphate in the blood were normal."
 

Recoen

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Good call!

Another important part is blood Thiamine levels can test normal while still having a deficiency. Even people with Wieneke's Encephalitis can show normal blood levels of Thiamine. Simply put, the typical Thiamine blood tests to look for deficiency is almost useless.

"Fatigue was measured using the chronic fatigue syndrome scale, and the determination of thiamine and thiamine pyrophosphate levels in the blood was carried out through blood tests. The levels of thiamine and thiamine pyrophosphate in the blood were normal."
Exactly, even transketolase has problems. The OAT can be beneficial but I really think most should try some B1 - low and slow because of refeeding syndrome. And I would try HCl, ttfd, and benfo.
 
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