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When the dose is effective it treats so many symptoms for me: a weird, exaggerated anxiety, depressed sensations, restless muscles, & related insomnia. When I get the dose right I just feel like a better me. Again, apologies. I haven't got a rhythm yet.
I think the minocycline price has to do with patents
I have tried doxy and penicillin, doses of 25-50mg at a time. Doxy gives me good vibes, clear head etc. I only take it intermittently, and only low doses as per Peat's methods.
Somewhere around 25 mg is my lowest dose, that's only for mood enhancement, I wouldn't bother with tapering unless I was taking 100mg or more. I don't take AB very often, if i had disbiosis, I would take it steadily at low doses multiple xs a day in conjunction with charcoal, and careful food intake.What kinda of doses are low doses for you? Do you taper off of it?
Somewhere around 25 mg is my lowest dose, that's only for mood enhancement, I wouldn't bother with tapering unless I was taking 100mg or more. I don't take AB very often, if i had disbiosis, I would take it steadily at low doses multiple xs a day in conjunction with charcoal, and careful food intake.![]()
I do, I don't take them at the same time.Interesting, thanks.
And you don't worry about the charcoal absorbing the antibiotic?
I've used it, I feel as though it is a more powerful anti biotic and using it haphazardly risks disbiosis. Also, it does not give a feeling of well being like doxy.Any experiences with Penicillin VK? Why no mention?
I suspected that in the past although I can't prove it was the doxycycline because I had a lot of issues at the time. This post might interest you if you haven't seen it before.Any one had water retention and water weight gain from their tetracycline (doxy or mino)?
Fat gain?
I posted a study about a month ago showing that the tetracycline class of antibiotics are potent inhibitors for a large number of cancer types. The proposed mechanism of action in that study was the fact that the tetracyclines were very toxic to the tumor mitochondria.
This study found that the tetracyclines inhibit mitochondrial respiration in normal cells too. I wonder what would Ray say about that and what the impact is for people using those antibiotics on a regular basis for gut issues.
Perhaps more interestingly (and in support of Peat's endorsement of the tetracyclines), despite the decrease in mitochondrial respiration organisms treated with a tetracycline antibiotic were more agile as they aged - i.e. they did not exhibit decline in physical/mental fitness with age.
So, what's going on here - tetracyclines cause lower respiration/metabolism but improved fitness??
http://www.the-scientist.com//?articles ... ochondria/
"... Two years ago, study coauthor Johan Auwerx, an energy metabolism researcher at the École Polytechnique Fédérale in Lausanne, Switzerland, and his colleagues observed that the tetracycline class of antibiotics, which target mitochondrial translation, led to an imbalance between mitochondrial and nuclear protein translation in both worms and mammalian cell lines. Expanding on this observation, the researchers have now shown that even low concentrations of tetracyclines can inhibit mitochondrial function and lead to changes in both mitochondrial and nuclear protein expression. Across four commonly used human cell lines, as little as 1 microgram of the drug per milliliter resulted in a decrease in cellular respiration, signaling impaired mitochondrial activity. Treatment with amoxicillin, an antibiotic that does not target protein synthesis in the mitochondria, did not lead to these effects. Further, genome-wide expression data showed global repression of mitochondrial protein synthesis in the presence of the tetracycline doxycycline.
In C. elegans and D. melanogaster, doxycycline exposure during development resulted in developmental delays as well as decreased oxygen consumption when the animals reached adulthood. However, both the doxycycline-treated worms and the fruit flies were more agile throughout their lives compared to those not exposed to the antibiotic, Auwerx and his colleagues found. This observation was consistent with the authors’ previous findings that blocking mitochondrial translation can partly prevent a decline in physical fitness with age."