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Jan 6, 2015
Even subantimicrobical dose, improves bone quality .

And apparently minocycline is the best tetracycline. But doxycycline is also interesting.

Effects of tetracyclines on bones: an ambiguous question needs to be clarified. - PubMed - NCBI

Effects of tetracyclines on bone metabolism. - PubMed - NCBI


Doxycycline induces bone repair and changes in Wnt signalling

MMPs degrade virtually all constituents of the extracellular matrix. MMPs are critical for connective tissue remodelling and healing as well as bone healing after tooth extraction.11, 12 The molecular environment of chronic wounds contains high levels of pro-inflammatory cytokines and MMPs, which impair normal healing. This process is positively affected by DOX.13, 14 Previously, the systemic administration of DOX has been found to prevent both root resorption and bone loss in rats.15

Furthermore, the Wnt signalling pathway (involving proteins that pass signals into a cell through cell surface receptors) plays a key role in bone development and homeostasis. Wnt ligands promote bone growth, thereby leading to the hypothesis that Wnt signalling activation may stimulate bone healing.16 Dysregulation of this pathway greatly inhibits bone formation and the healing process, thus suggesting that this pathway has an essential role in bone regeneration.17 Wnt signalling is activated by wounding and participates in every stage of the healing process, from the control of inflammation and programmed cell death to the mobilisation of stem cell reservoirs within the wound site.18

Furthermore, signalling via the classical Wnt pathway is critical for bone deposition and bone remodelling. Among other mechanisms, this signalling pathway is regulated by Dickkopf proteins (Dkks), which bind and promote the internalisation of lipoprotein receptor-related protein (LRP)5 or LRP6. Blocking these Wnt receptor components effectively downregulates Wnt signalling. Dkk has been implicated in bone formation and bone diseases. The induction of the Wnt signalling pathway promotes bone formation, whereas its inactivation by Dkk leads to osteopenic states.19

Given the anti-inflammatory and MMPs inhibitory properties of DOX, the objectives of the present work were to use histological and histomorphometric methods to evaluate the effects of DOX on alveolar bone repair after tooth extraction in rats. In addition, we performed immunohistochemistry detecting Wnt-10b and its inhibitor Dkk-1.
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