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Doxycycline is beeing increasingly studied for its anti-inflammatory effects at sub-antimicrobial doses.
This study shows how and that it might be helpful in avoiding liver scarring/fibrosis.
It shows that MMP-8, which is released in response to LPS, activates the hepatic stellate cells...
High molecular weight coffee melanoidins are inhibitors for matrix metalloproteases. - PubMed - NCBI
Abstract
High molecular (above 10 kDa) melanoidins isolated from coffee beans of varying roasting degree were found to be efficient inhibitors for the zinc-containing matrix metalloproteases...
Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline
Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline
D R Bach
, A Tzovara
& J Vunder
Molecular Psychiatry
doi:10.1038/mp.2017.65
Download Citation
Neuroscience
Received:
05...
Lol sorry , couldn't find better tittle for this.
Probably low, nonantibacterial dose of doxycycline is what we need for these effects. Like 20-40mg a day.
Antioxidant Response of Osteoblasts to Doxycycline in an Inflammatory Model Induced by C-reactive Protein and Interleukin-6
Objectives...
Even subantimicrobical dose, improves bone quality .
And apparently minocycline is the best tetracycline. But doxycycline is also interesting.
Effects of tetracyclines on bones: an ambiguous question needs to be clarified. - PubMed - NCBI
Effects of tetracyclines on bone metabolism. -...
Here probably i only post positives about igf1, as ray seeing it generally on reparative ,constructive side.(according to danny roddy,thanks to him)
it is interesting most nutrient deficiencies lower igf1 but not GH!
Hypothyroids have lower level of igf1...
I probably will edit this post and update it.
Magnesium and tnf alpha interaction
Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. - PubMed - NCBI
Adequate zinc intake is necessary for protection against tnf alpha and pufa
Zinc nutrition and...
Meet your new beauty ingredient - ketotifen. UV light exposure is one of the main triggers of visible signs of skin aging and contributes to lipofuscin formation as well. It looks like ketotifen may be able to prevent that damage and given its leukotriene and histamine antagonism it may be a...