Coronavirus spike protein creates inflammation via CD147, antibiotics treat

Mauritio

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Another study on the infamous spike protein:

So there's several studies showing that the SARS-cov-2 spike protein binds to a protein called basigin or CD147 . This can damage the pericytes in the heart, which can lead to aneurysms and other problems. CD147 is a marker of inflammation and another way of entry for the virus into the body.

"Importantly, we show that the recombinant S protein alone elicits cellular signalling through the CD147 receptor in cardiac PCs, thereby inducing cell dysfunction and microvascular disruption in vitro.
This study suggests that soluble S protein can potentially propagate damage to organs distant from sites of infection, promoting microvascular injury. Blocking the CD147 receptor in patients may help protect the vasculature not only from infection, but also from the collateral damage caused by the S protein."

"Together, our study reveals a novel virus entry route, CD147-spike protein, which provides an important target for developing specific and effective drug against COVID-19."
(CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells - Signal Transduction and Targeted Therapy)

Even wikipedia admits it :
"More recent studies suggests CD147 as SARS-CoV-2 entry receptor of platelets and megakaryocytes, leading to hyperactivation and thrombosis, that differs from common cold coronavirus CoV-OC43. Incubation of megakaryocytecells with SARS-CoV-2 resulted in a significant increase in the proinflammatory transcripts LGALS3BP and S100A9. Notably, CD147 antibody-mediated blocking significantly reduced the expression of S100A9, and S100A8 on megakaryocytes following incubation with SARS-CoV-2. These data indicate that megakaryocytes and platelets actively take up SARS-CoV-2 virions, likely via an ACE-2-independent mechanism.[21]"

This study shows that this might not only affect our hearts but also our brains:
"CD147 is highly expressed in mouse brain tissue compared to lung tissue, suggesting that SARS-CoV-2 may bind to CD147 in the brain [24]."
(The Effect of COVID-19 on NF-κB and Neurological Manifestations of Disease)

Cd147 might also have a strong anti-metabolism /pro-cancer effects.
CD147 induces MCTs (CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression - PubMed) ,which is the lactate transporter on which highly malignant tumors are dependent.

"Highly malignant tumors rely heavily on anaerobic glycolysis (metabolism of glucose to lactic acid even under presence of oxygen; Warburg effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death".[4][5]"
(Monocarboxylate transporter - Wikipedia)

So this adds another way through which the spike protein creates damage and inflammation:
1. ACE2 (Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19) - PubMed)

2. TLR4 (SARS-cov-2 spike protein activates endotoxin receptor TLR4)

3. HSPA4
(Testosterone, progesterone, caffeine and thymoquinone inhibit Coronavirus through HSP-binding)

4. CD147


In terms of treatment I couldn't find much on the usual suspects like testosterone or aspirin. The most promising candidates seem to be antibiotics :

-Doxycycline
(Zhang et al. [63] provided evidence that chimeric antigen receptor T cells induced by doxycycline targeting BSG could be used in the treatment of liver cancer. Another study also found that doxycycline inhibited the proliferation of gallbladder cancer cells by downregulating the expression levels of BSG and induced an early apoptosis response in cancer cells [64].
(Immunohistochemical basigin expression level in thyroid cancer tissues - World Journal of Surgical Oncology)

-Minocycline
"Minocycline intervention significantly reduced the activity of CD147."
(Effect of minocycline on carotid atherosclerotic plaques - PubMed)

- Azithromycin (CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement - PubMed)
 
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Birdie

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Dr Zev's original protocol using Azithromycin or Doxy.. More evidence here. Thanks @Mauritio. I need to keep reading stuff like this when all the bull**** hits, which is almost always.
 
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Mauritio

Mauritio

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Dr Zev's original protocol using Azithromycin or Doxy.. More evidence here. Thanks @Mauritio. I need to keep reading stuff like this when all the bull**** hits, which is almost always.
Yeah I think adding low dose antibiotics to the "covid stack" would be good. Especially the tetracyclines have good anti-inflammatory effects , even in low doses.
We're all exposed to spike proteins and the more you ,the better you can defend yourself.

What else does this doc suggest?
 
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Mauritio

Mauritio

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Doxycycline to the rescue again!
There's a strong relation between MMP-concentration and covid severity. Doxycycline inhibits MMPs even in sub-antimicrobial dosages.

"We further studied MMP-1 enzymatic activity and multiple endothelial cell (EC) activation markers (soluble forms of CD146, intercellular adhesion molecule 1 [ICAM-1], and vascular cell adhesion molecule 1 [VCAM-1]) and found that they were highly dysregulated in COVID-19 patients."

"In conclusion, serum MMP3 may help to early predict the severity of COVID-19 and both proteins, MMP3 and MMP9, may contribute to define severe COVID-19 patients that may benefit from a targeted therapy on MMPs."

"Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles."
 
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Mauritio

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tankasnowgod

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"Importantly, we show that the recombinant S protein alone elicits cellular signalling through the CD147 receptor in cardiac PCs, thereby inducing cell dysfunction and microvascular disruption in vitro.

You didn't emphasize the word "recombinant," but it's pretty important. That's what tells you this is a synthetic version of the alleged "Spike Protein." I think all of these in vitro experiments would have to use a synthetic version, as neither the alleged "Novel Corona Virus" nor the alleged "Spike Protein" has ever been isolated and purified.

This experiment got me thinking...... how did they manage to isolate and purify the "Spike Protein" from SARS-Cov-2, when they never even managed to isolate and purify this "Novel Corona Virus" from the other cellular material when they allegedly "discovered" it in the first place?


The short answer is..... they didn't. The study itself doesn't even make such a claim (contrary to how the title is written). The whole story is told in right here, in the Abstract-



Did you gloss over that word "recombinant?" You shouldn't. It means this is a synthetic protein.










As always, the "Materials and Methods" section gives further detail-





Here is the listing from ProSci-


They can claim this synthetic protein is the same as the "Spike Protein" from "SARS-Cov-2, but since neither the alleged virus, nor the alleged spike protein has been isolated and purified, how would anyone possibly know?

Although, since ProSci charges over $500 for 0.1 mg (!!!!), I'm guessing they don't care. And probably prefer no one ask that question.
 
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Mauritio

Mauritio

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You didn't emphasize the word "recombinant," but it's pretty important. That's what tells you this is a synthetic version of the alleged "Spike Protein." I think all of these in vitro experiments would have to use a synthetic version, as neither the alleged "Novel Corona Virus" nor the alleged "Spike Protein" has ever been isolated and purified.
There's a great interview with Peat by patrick timpone. I think it was in March or February of 2021 where he talks about the "it hasn't been isolated" argument.

You don't have to purify chemicals to identify them"
"You dont have to isolate a chemical to be confident that it exists."
-RP
 

tankasnowgod

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There's a great interview with Peat by patrick timpone. I think it was in March or February of 2021 where he talks about the "it hasn't been isolated" argument.

You don't have to purify chemicals to identify them"
"You dont have to isolate a chemical to be confident that it exists."
-RP
This is irrelevant to the point I made.

The above experiment used a genetically modified protein that they are claiming is identical to the alleged "spike protein" on the alleged "Novel Corona Virus."

Taking Peat's quotes at face value, the following picture may indeed be enough to claim that SARS-Cov-2 exists, even though it's clearly only microns away from the cell that it apparently came from (the arrows in D point to it)

Covid.jpg


But is that enough to correctly genetically sequence it? And then identify the part of the sequence that correctly belongs to the "Spike Protein," and "Spike Protein" only? And is it enough to recreate a "recombinant" version? And to be sure this "recombinant" version will have all the exact same qualities as the alleged "Spike Protein?"

Side note- Did Peat go over what he thought about these so called "isolation" experiments? If you look at the "Materials and Methods," it seems like they do a lot of questionable things to arrive at image in D. Like, adding Fetal Bovine Serum, using antibiotics and antimycotics, and trypsinizing the cells. It seems like this adds genetic contamination and damages the cell. Even if the sample doesn't have to be "purified," I would think you would at least want to refrain from adding contaminants, and using substances to damage the cells you are working with.

But if Peat has a good explanation for why this is okay, it might be worth a listen
 
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