Hello @haidut , I really need your advice. I have been taking high doses(32mg per day) of cypro for a week now, which I have done successfully before and everything was fine and now my condition is just as great, but I am afraid this began to give severe side effects on the liver: when I stopped caffeine, week with huge doses of cypro made my liver to bother me - my stool turned yellow and when I added caffeine again as an experiment i completely lost my tolerance and my standard five espressos gave me such a shitty stress feeling, also my kidneys started to hurt a little, I drank huge doses of caffeine and silymarin and then symptoms disappeared. Do you think it really was liver damage and does that mean that I can never go back to taking cypro? Although it works wonders for everything else .... And then I do not understand how patients with Cushing's syndrome could tolerate such huge doses of cypro with a crappy diet and very likely avoiding caffeine and aspirin?I have taken up to 24mg daily, back in 2012-2013 timeframe and it can be done but the key is to first use low dose (2mg-4mg daily) for 7-10 days, as after that the drowsiness and catatonic feelings go away. Most studies for Cushing disease/syndrome use cypro doses in the 24mg-32mg daily range and those people functioned just fine...aside from the severe initial drowsiness.