Androgen Treatment Highly Effective For Breast Cancer

haidut

Member
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
The first study (animal) looked at various approaches and found that removal of the pituitary caused the complete disappearance of breast cancer in ALL of the studied animals. The administration of DHT caused almost complete regression in 82% (14 out of 17) of the animals. The HED for DHT was 0.7mg/kg. The second study (human case study) used a combination of testosterone (T) and the aromatase inhibitor (AI) anastrozole. You can think of the DHT in the first study as having the same effect as the T + AI combo in the second one - i.e. androgenic and anti-estrogenic. So, in effect both studies observed the same effect, and they were done 7 decades apart. The human study observed 12-fold reduction in tumor size in period of just 3 months! If this effect was achieved by a novel pharma drug it would be on TV 24 hours a day for months. But alas, it was just a humble combination of T and an out-of-patent AI. The human study also refers to a potentially even better approach - using DHEA, with or without AI. DHEA has shown better cancer-inhibiting properties in pre-clinical studies. So, the OTC combination to implement the same approach would be a DHEA + progesterone or DHEA + pregnenolone combination.
An interesting side note is that DHT caused marked increase in normal breast size while inhibiting tumor growth. This matches well the studies I posted on DHEA being able to increase breast size when applied topically. So, androgens are not only for men :):

RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS
"...Many of the induced carcinomas, indeed the majority of them, regressed markedly in size when ovarian function was abolished by ovariectomy or by hypophysectomy; removal of the pituitary always was followed by the greatest decline in tumor size. Cancers behaving in this way are by definition hormone- dependent. This decrease in size was not due to necrosis but to atrophy of the epithelial cells, resulting in a characteristic histologic appearance. Similarly, the administration of dihydrotestosterone caused hormone- dependent cancers to decrease in size; this compound, in common with other androgenic substances, is known to induce a decline of ovarian function yet, notably, promotes growth intensely in the normal mammary epithelium of the rat (27, 28). It was of interest to observe vigorous growth of the normal mammary tree in rats injected with dihydrotestosterone whilst the mammary cancers became atrophic in the same animals."

Rapid response of breast cancer to neoadjuvant intramammary... : Menopause
"...Follow-up mammogram (Fig. 2) and US (Fig. 3) on week 13, again performed at the same radiology facility, revealed that the size of the carcinoma had continued to decrease, measuring 1.5 × 0.8 × 0.6 cm on US, with a tumor volume of 0.42 cm3. This 12-fold reduction in tumor volume from the original measurement equates to a 2.78% decrease per day (after therapy) and a half-lifeb of 23 days. The logarithmic response of the carcinoma to T + A therapy is evidenced by an R2 value greater than 0.99 (Fig. 4). In addition, many of the patient’s symptoms, including memory loss, physical fatigue, urinary incontinence, sleep disturbance, depression, and pain, improved with testosterone therapy. Adequate serum levels of testosterone, without elevation of E2, were confirmed on day 7 postinsertion (testosterone, 473 ng/dL; E2 <5 pg/mL), day 46 postinsertion (testosterone, 366 ng/dL; E2 <5 pg/mL), and again on day 7 after the second intramammary insertion procedure (testosterone, 345 ng/dL; E2 <5 pg/mL). Interestingly, the patient was able to discontinue several medications in addition to tamoxifen, including duloxetine HCl, lisinopril, and atorvastatin. There have been no adverse drug events with therapy. The patient “feels better than she has in years,” is no longer using a walker, and is driving her car again. She continues to refuse any surgical intervention."
 
Last edited:

Lightbringer

Member
Joined
Jan 24, 2014
Messages
235
An interesting side note is that DHT caused marked increase in normal breast size while inhibiting tumor growth. This matches well the studies I posted on DHEA being able to increase breast size when applied topically. So, androgens are not only for men

I was reading about the Star Wars actress (Daisy Ridley) talking about PCOS which I assume is related to an excess of androgens ?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
I was reading about the Star Wars actress (Daisy Ridley) talking about PCOS which I assume is related to an excess of androgens ?

Nope, it is actually driven by estrogen even though the superficial symptoms are related to local androgen metabolism. Search the forum and Peat's website. There is a ton of info on how estrogen irritates the adrenals
 
Last edited:
Joined
Nov 11, 2014
Messages
584
I was reading about the Star Wars actress (Daisy Ridley) talking about PCOS which I assume is related to an excess of androgens ?

It's not wonder -- have a look at her meals and exercise routine on instagram.

The majority of Hollywood actresses/actors are continuously running on adrenaline and cortisol with their low-carb high-resistance training routines. I'm also noticing varicose veins in the temple area of foreheads in people in their early 20s. Estrogen is everywhere.
 

dand

Member
Joined
Jul 3, 2014
Messages
228
Bravo bravo! I hope you're saving all of this material to somewhere. I would not put it past the pharmas trying to come around and shut things down. THANK YOU FOR THIS!
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
Bravo bravo! I hope you're saving all of this material to somewhere. I would not put it past the pharmas trying to come around and shut things down. THANK YOU FOR THIS!

Thanks Dan! Yes, saving my posts in the separate database just in case. I think @charlie is also making unscheduled forum backups and hiding them under his pillow :):
 

Koveras

Member
Joined
Dec 17, 2015
Messages
719
The first study (animal) looked at various approaches and found that removal of the pituitary caused the complete disappearance of breast cancer in ALL of the studied animals. The administration of DHT caused almost complete regression in 82% (14 out of 17) of the animals. The HED for DHT was 0.7mg/kg. The second study (human case study) used a combination of testosterone (T) and the aromatase inhibitor (AI) anastrozole. You can think of the DHT in the first study as having the same effect as the T + AI combo in the second one - i.e. androgenic and anti-estrogenic. So, in effect both studies observed the same effect, and they were done 7 decades apart. The human study observed 12-fold reduction in tumor size in period of just 3 months!!! If this effect was achieved by a novel pharma drug it would be on TV 24 hours a day for months. But alas, it was just a humble combination of T and an out-of-patent AI. The human study also refers to a potentially even better approach - using DHEA, with or without AI. DHEA has shown better cancer-inhibiting properties in pre-clinical studies. So, the OTC combination to implement the same approach would be a DHEA + progesterone or DHEA + pregnenolone combination.
An interesting side note is that DHT caused marked increase in normal breast size while inhibiting tumor growth. This matches well the studies I posted on DHEA being able to increase breast size when applied topically. So, androgens are not only for men :):

RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS
"...Many of the induced carcinomas, indeed the majority of them, regressed markedly in size when ovarian function was abolished by ovariectomy or by hypophysectomy; removal of the pituitary always was followed by the greatest decline in tumor size. Cancers behaving in this way are by definition hormone- dependent. This decrease in size was not due to necrosis but to atrophy of the epithelial cells, resulting in a characteristic histologic appearance. Similarly, the administration of dihydrotestosterone caused hormone- dependent cancers to decrease in size; this compound, in common with other androgenic substances, is known to induce a decline of ovarian function yet, notably, promotes growth intensely in the normal mammary epithelium of the rat (27, 28). It was of interest to observe vigorous growth of the normal mammary tree in rats injected with dihydrotestosterone whilst the mammary cancers became atrophic in the same animals."

Rapid response of breast cancer to neoadjuvant intramammary... : Menopause
"...Follow-up mammogram (Fig. 2) and US (Fig. 3) on week 13, again performed at the same radiology facility, revealed that the size of the carcinoma had continued to decrease, measuring 1.5 × 0.8 × 0.6 cm on US, with a tumor volume of 0.42 cm3. This 12-fold reduction in tumor volume from the original measurement equates to a 2.78% decrease per day (after therapy) and a half-lifeb of 23 days. The logarithmic response of the carcinoma to T + A therapy is evidenced by an R2 value greater than 0.99 (Fig. 4). In addition, many of the patient’s symptoms, including memory loss, physical fatigue, urinary incontinence, sleep disturbance, depression, and pain, improved with testosterone therapy. Adequate serum levels of testosterone, without elevation of E2, were confirmed on day 7 postinsertion (testosterone, 473 ng/dL; E2 <5 pg/mL), day 46 postinsertion (testosterone, 366 ng/dL; E2 <5 pg/mL), and again on day 7 after the second intramammary insertion procedure (testosterone, 345 ng/dL; E2 <5 pg/mL). Interestingly, the patient was able to discontinue several medications in addition to tamoxifen, including duloxetine HCl, lisinopril, and atorvastatin. There have been no adverse drug events with therapy. The patient “feels better than she has in years,” is no longer using a walker, and is driving her car again. She continues to refuse any surgical intervention."

Interesting in conjunction with this - Inhibiting Lipolysis May Treat / Cure Cancer ...that androgens inhibit lipolysis in women.

Screen Shot 2018-01-11 at 1.03.42 PM.png Screen Shot 2018-01-11 at 1.05.02 PM.png

Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.

I'd always found it confusing that androgens were said to promote insulin resistance in women (as in PCOS for example) - but it seems that the androgens themselves still promote insulin sensitivity, but the increased insulin sensitivity in fat cells + reduction in lipolysis + (most importantly) a shitty diet = increased gain in fat mass ...which follows with insulin resistance once those fat cells are full due to the diet.

Another nice graphic from the same study - has been covered before - but good luck losing weight with calorie restriction when testosterone is sub-optimal in men

Screen Shot 2018-01-11 at 1.06.57 PM.png
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,787
Location
USA / Europe
Would aromasin go well with 10mg dhea daily

I would not take a 10mg dose to start with. A 5mg dose a few times daily is probably much safer. Also, progesterone (and possibly androsterone/DHT) are preferable as AI than something like aromasin.
 
Similar threads
Thread starter Title Forum Replies Date
A Urobolin/Urolithin B increases androgen receptors more than testosterone? Diet 1
haidut DHT, not T, likely the "active" androgen in heart and brain Scientific Studies 0
GorillaHead According to this study the androgen receptor is basically repressed Hair & Nails 1
H Progest-e dosages for a girl w est/androgen dominance Ask For Help or Advice 41
Mauritio Dutasteride / Finasteride cause fibrosis of the penis and prostate; decrease androgen receptors, increase estrogen receptors Scientific Studies 9
Zsazsa Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein Scientific Studies 0
TheBeard Fetal androgen exposure is a determinant of adult male metabolic health Thyroid and Hormones 3
Hgreen56 High sugar consumption could cause the body to become unable to regulate androgen levels? Hormones 21
D Is Beard Growth Androgen, Estrogen, or Nitric Oxide related? Or all the above? Male Issues 30
5 Chronic, High-Dose Androgen Use and Adrenal Suppression Male Issues 0
Mito Early decline of androgen levels in healthy adult men: an effect of aging per se? Scientific Studies 1
johnwester130 Anti-Peat DHEA is an anti-androgen Debate - Anti-Peat 8
Spartan300 Low Androgen Symptoms - Tests Ok - Time To Rethink Male Issues 33
haidut Dietary PUFA Causes (reversible) Male Infertility And Androgen Deficiency Scientific Studies 4
S DHT And Reversing Androgen-receptor Deficiency Ask For Help or Advice 21
J CPT1 And Androgen Receptor Male Issues 0
Lokzo Estrogen Up-regulates Androgen Receptors (AR) In The Brain Scientific Studies 5
Lokzo Inhibition Of Androgen Receptor Can Decrease Fat Metabolism In Skeletal Muscles Of Trained Mice Scientific Studies 0
Hans What Androgen Related Symptoms Do You Suffer From? Polls 6
R The Gut Microbiota Is A Major Regulator Of Androgen Metabolism In Intestinal Contents Scientific Studies 1
haidut Drop In Androgen Levels Causes Parkinson Disease (PD), DHT Reverses It Scientific Studies 39
W ANDROGEN BLOCKERS Male Issues 0
L 2 Recent Studies On Cortisol/androgen Relationship Scientific Studies 0
L The Anabolic Potencies Of Different Androgen Hormones? Thyroid and Hormones 3
Cameron Forskolin Estrogenic Or Powerful Androgen Booster Through Camp? Supplements, Pharmaceutical Drugs 1
jase_11six How To Increase Androgen Receptors In My Cheek ? Hair & Nails 133
Cameron Low Dose (3-5mg) Test And Dht Topical For Massive Androgen Increase Male Issues 54
Lokzo Serotonin Regulates Prostate Growth Through Androgen Receptor Modulation Scientific Studies 3
Sajid Androgen Receptor Sensitivity Ask For Help or Advice 2
alex00 Androgen Receptors Question Supplements, Pharmaceutical Drugs 21
haidut High Estrogen (Androgen Deficiency) Causes Low Vitamin D; DHT Is Therapeutic Scientific Studies 14
T LSD1 Has Dual Functions As A Major Regulator Of Androgen Receptor Transcriptional Activity Scientific Studies 4
haidut Androgen Deficiency As The Main Cause Of Chronic Disease In Males Scientific Studies 108
L Unexpected Central Role Of The Androgen Receptor In The Spontaneous Regeneration Of Myelin Scientific Studies 20
vulture "Physiological Normal Levels Of Androgen Inhibit Proliferation Of Prostate Cancer Cells In Vitro" Scientific Studies 5
jacknap RU58841 Crash Story (Anti-Androgen Seems Like Post Finasteride Sydndrome) Blood Work, Labs 13
M How To Reduce Adrenal Androgen Excess Supplements 1
Black Ops Are The B-vitamins Important For Androgen Production? (Which Ones Specifically) Vitamins 10
haidut Palmitic Acid Is Androgen Agonist, Increases Androgen Synthesis, Decreases Cortisol Scientific Studies 27
haidut PUFA Is Estrogenic And Androgen/Progesterone Antagonist Scientific Studies 2
haidut Omega-3 (DHA, EPA) Degrades The Androgen Receptor Scientific Studies 7
Drareg The Cortisol And Androgen Pathways Cross Talk In High Temperature-Induced Masculinization: The 11β-H Scientific Studies 0
haidut Optimal Dose Of Pregnenolone For Androgen Synthesis Scientific Studies 109
haidut 5α-Dihydroprogesterone (5α-DHP) Is Androgen/Progesterone Agonist And Pro-hormone For DHT Scientific Studies 25
H METHYLENE BLUE AND ANDROGEN SYNTHESIS Methylene Blue 1
haidut Nitrates / Nitrites Inhibit Androgen Synthesis By Raising NO Scientific Studies 17
haidut Pineal Gland Chemicals Inhibit Androgen Synthesis Scientific Studies 2
haidut DIM Is A Potent Androgen Antagonist And Estrogen Agonist Scientific Studies 27
haidut Pregnenolone & Progesterone Are Both Agonists Of The Androgen Receptor Scientific Studies 24
haidut Estrogen Or Anti-androgen Therapy Shrinks Brain And Destroys Grey Matter Scientific Studies 3

Similar threads

Top