Serotonin Causes Liver Cancer And Metastases In Colon Cancer

haidut

Member
Joined
Mar 18, 2013
Messages
17,429
Location
USA / Europe
The role of serotonin in fibrosis is well-known despite the public lies thrown around by Big Pharma. I opsted about the behind-the-scenes acquisition of the serotonin antagonist terguride, which Pfizer is now hoping to be able to treat ANY fibrotic condition (as shown by a recently filed FDA application). Serotonin is closely associated with prolactin and both are known in the transplant industry as growth hormones - i.e. short term rise in their levels can benefit the regeneration of partially resected/removed organs like liver, kidneys, GI tract and spleen. However, chronic rise of their levels is known to cause a number of issues including fibrosis and cancer of the GI tract that collectively lead to the well-known "carcinoid sydrome". For decades mainstream medicine has been denying that serotonin has a causative role in fibrosis and cancer promotion despite the fact that people with the carcinoid syndrome die from fibrosis and not the actual cancer and its metastases.
This new study may change some of that preception in the medical circles as it found that serotonin is the primary cause of liver tumor (re)emergence and the development of metastases in colon cancer. I suppose the moment Pfizer see this study it will add yet another "indication" for their blockbuster drug, while continuing to sell SSRI. Hey @aguilaroja I think you will like this.
Btw, cyproheptadine has been shown to be therapeutic in liver, colon and other GI tract cancers and that fits perfectly with the study results below. The fact that vitamin K2 is about to be approved by the FDA for both prevention and treatment of liver cancer suggests that at least one of the mechanisms of that vitamin is antagonism to serotonin.

Bivalent role of intra-platelet serotonin in liver regeneration and tumor recurrence in humans. - PubMed - NCBI
Industry, Latest Industry News, Health News - ET HealthWorld
er-regeneration-following-liver-resection-for-liver-cancer-but-also-supports-early-tumour-regrowth/61142833
"..."The findings from this study are therefore of major importance for platelet-based treatment of post-operative liver failure," explains Patrick Starlinger, "While raising the amount of growth factors contained in the platelets, such as serotonin, has hitherto been regarded as an attractive treatment, we now see that this therapy also has a downside. Although higher serotonin levels reduce the risk of complications, in parallel, they increase the risk of developing early tumour recurrence within the first six months following liver resection with curative intent." Serotonin was found to have this double-edged effect not only in primary liver tumours but also in metastases of colorectal cancer."
 

Regina

Member
Joined
Aug 17, 2016
Messages
3,181
Location
Chicago
The role of serotonin in fibrosis is well-known despite the public lies thrown around by Big Pharma. I opsted about the behind-the-scenes acquisition of the serotonin antagonist terguride, which Pfizer is now hoping to be able to treat ANY fibrotic condition (as shown by a recently filed FDA application). Serotonin is closely associated with prolactin and both are known in the transplant industry as growth hormones - i.e. short term rise in their levels can benefit the regeneration of partially resected/removed organs like liver, kidneys, GI tract and spleen. However, chronic rise of their levels is known to cause a number of issues including fibrosis and cancer of the GI tract that collectively lead to the well-known "carcinoid sydrome". For decades mainstream medicine has been denying that serotonin has a causative role in fibrosis and cancer promotion despite the fact that people with the carcinoid syndrome die from fibrosis and not the actual cancer and its metastases.
This new study may change some of that preception in the medical circles as it found that serotonin is the primary cause of liver tumor (re)emergence and the development of metastases in colon cancer. I suppose the moment Pfizer see this study it will add yet another "indication" for their blockbuster drug, while continuing to sell SSRI. Hey @aguilaroja I think you will like this.
Btw, cyproheptadine has been shown to be therapeutic in liver, colon and other GI tract cancers and that fits perfectly with the study results below. The fact that vitamin K2 is about to be approved by the FDA for both prevention and treatment of liver cancer suggests that at least one of the mechanisms of that vitamin is antagonism to serotonin.

Bivalent role of intra-platelet serotonin in liver regeneration and tumor recurrence in humans. - PubMed - NCBI
Industry, Latest Industry News, Health News - ET HealthWorld
er-regeneration-following-liver-resection-for-liver-cancer-but-also-supports-early-tumour-regrowth/61142833
"..."The findings from this study are therefore of major importance for platelet-based treatment of post-operative liver failure," explains Patrick Starlinger, "While raising the amount of growth factors contained in the platelets, such as serotonin, has hitherto been regarded as an attractive treatment, we now see that this therapy also has a downside. Although higher serotonin levels reduce the risk of complications, in parallel, they increase the risk of developing early tumour recurrence within the first six months following liver resection with curative intent." Serotonin was found to have this double-edged effect not only in primary liver tumours but also in metastases of colorectal cancer."
:thumbsup::darts:
 

michael94

Member
Joined
Oct 11, 2015
Messages
2,133
I'm quite positive that sero-tonin has the same effects on vile duct dilation/constriction as blood vessels, which isn't really any surprise I guess...

The fibrosis may be trying to contain the damage though, depending on the circumstances. Eros-tonin constricts love in order to prevent it from being corrupted...
 

Amazoniac

Member
Joined
Sep 10, 2014
Messages
7,748
Location
Not Uganda
Doctors are now more careful with their words. It's all more subtle and safer now, no open statements, no open condemnation of a patient. There's no clear positioning anymore, except when the family manifests any desire to remove the patient and refuse the pushed procedures, then the constant menaces start to appear. All else is very vague.
I'm mentioning this because when a patient is openly condemned, the family mobilizes the will that it needs to take action when the standard procedures are failing, or when they feel that the person was abandoned by the hospital. However, with the "oh, we never know how the body is going to respond", "there's always a chance, but we can't be sure", etc. The family is left deluded that a miracle is going to happen if they keep hoping.
There are simple measures that if taken in time could change the course of a person's life. Ray's idea of providing small doses of T3 every hour, nutritional support with antibiotics while restricting iron, increments of cyproheptadine, light, and so on. If only the monitoring tools of the hospital could be used along with those, but doctors prefer to let the person die than to.. risk saving a life against the norms.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,429
Location
USA / Europe
Does that mean K2 will be banned?

Yes, once it gets approved it will likely become prescription drug like Glakay in Japan. The FDA has already banned vitamins in the past because they were declared drugs based on a company's study.
Pyridoxamine - Wikipedia
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,429
Location
USA / Europe
Similar threads
Thread starter Title Forum Replies Date
Mauritio Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO Scientific Studies 0
haidut Prenatal Stress Ups Serotonin, Which Causes Autism And Mental Disease In Offspring Scientific Studies 0
haidut Serotonin Causes Anhedonia. And Mental Illness In General Scientific Studies 2
haidut Serotonin Causes The Startle Response, And Likely PTSD As Well Scientific Studies 19
Such_Umami Fruit Causes Adrenaline Energy And Starch Produces Serotonin Energy Ask For Help or Advice 4
Gadsie (Anti Peat?) Serotonin Depletion Causes Hypothermia Scientific Studies 2
Dessert_All_Day When Grasshoppers Go Biblical: Serotonin Causes Locusts To Swarm Articles & Scientific Studies 22
haidut Serotonin Causes Bipolar Disorder (through Mitochondrial Dysfunction) Scientific Studies 3
goodandevil Serotonin Causes Obesity Scientific Studies 0
haidut Serotonin Causes Obesity And Diabetes In Humans Scientific Studies 62
haidut Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked Scientific Studies 39
ecstatichamster If Serotonin Excess Causes Fibrosis, Why Do Drugs Inhibiting Serotonin Cause Fibrosis Cortisol, Serotonin, Histamine 14
haidut Stress Activates A Serotonin Gene In Pregnant Women And That Causes Autism Scientific Studies 8
haidut Maternal Inflammation Causes Brain Damage (autism) By Raising Serotonin Scientific Studies 18
haidut Poverty Causes Depression By Increasing Serotonin Activity Scientific Studies 53
haidut Serotonin Causes Autism; Blocking It May Treat Autism Scientific Studies 35
haidut Serotonin And Nitric Oxide Are The True Causes Of Migraine Scientific Studies 8
Mito Serotonin Pathway in Cancer Cancer 1
deliciousfruit I Think High Serotonin Is Holding Me Back Ask For Help or Advice 9
N The "safest" drug to increase serotonin Mental Issues 19
Mito Serotonin receptor 4 in the hippocampus modulates mood and anxiety Articles & Scientific Studies 0
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 15
Mauritio 10-methoxy-harmalan ,an anti-serotonin chemical? IdeaLabs 34
Lokzo Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED Supplements, Pharmaceutical Drugs 2
GelatinGoblin Low-Moderate sugar meal with no Protein, Serotonin inducing? Ask For Help or Advice 5
Mito Serotonin is elevated in COVID- 19-associated diarrhoea Miscellaneous Health Discussions 39
Atma Ray Peat Interview #30: LSD, Serotonin, and Hallucinations | PUFA and Lipofuscin | Strategy of Tension | William Blake Interviews 4
haidut Serotonin promotes (futile) patience and (false) faith in future rewards Scientific Studies 18
haidut Serotonin (and SSRI drugs) can cause anxiety and PTSD Scientific Studies 0
haidut Serotonin may cause schizophrenia, Parkinson, and Alzheimer diseases Scientific Studies 2
deliciousfruit cyproheptadine increasing serotonin? Cyproheptadine 23
GorillaHead Is the key to procrastination patience? And is serotonin the key patience? Mental Issues 13
Lokzo This Is How The Carnivore Diet Lowers Serotonin... Diet, Recipes 7
Mauritio Serotonin Depletion Amplifies Distinct Human Social Emotions As A Function Of Individual Differences Scientific Studies 4
Lokzo Do You Have Too Much Serotonin? Miscellaneous Health Discussions 0
DANIEL A High Serotonin Society | Morning Routines, Self-Improvement, Habit Tracking Miscellaneous 1
Lokzo Understand Your Serotonin: What Is Serotonin & How Is It Made? Cortisol, Serotonin, Histamine 3
Lokzo The Expanded Biology Of Serotonin Scientific Studies 0
pauljacob Is Serotonin Good Or Bad? Supplements, Pharmaceutical Drugs 3
haidut Irritable Bowel Syndrome (IBS) Caused By Histamine And Serotonin Scientific Studies 3
M Brain Supplement Recommendations For People With Serotonin Sensitivity Ask For Help or Advice 2
N Girlfriend And I Took LSD And She Got Terrible Stomach Aches - Serotonin/dopamine? Cortisol, Serotonin, Histamine 16
A Serotonin And Diarrhea? Ask For Help or Advice 3
MaxVerstappen Microdosing Mushrooms To Reduce Serotonin Autism 36
Amazigh The Serotonin Receptors: Comparing The Binding Affinity Of 5 Psychedelics Scientific Studies 1
M Does "improving" Serotonin Receptors Help Or Hinder Serotonin Sensitivity? Ask For Help or Advice 5
Energizer Ray Peat Interview What's So Happy About Serotonin? Butter Living (8/6/2020) Interviews 6
David PS What's So Happy About Serotonin? With Ray Peat (Butter Living Podcast) Interviews 0
metabolizm The Varicocele: Elevated Serotonin And Infertility (1980) Scientific Studies 9
D Possible Ways To Lower Serotonin In Young Children Autism 10

Similar threads

Top