Capsaicin increases Testosterone by 2,5 fold

[Mauritio]

In this study Capsicin had a huge effect on testosterone in mice. When given to pubertal mice for 40 days it increased T about 1,5 fold , but the real magic happened in the adult animals that got the pepper for 70 days: they increased their T by 2,5 fold!
I'm not sure how the dosage correlates to HED but the researchers called it a low dose (0.02%) , but I think that is a relativeley high dose. But lower doses might still be effective, they just didn't look for it.

I remember @Lokzo posted a study on a very androgenic pepper , maybe it was realted to its capsaicin content.
@cs3000 you'll want to see this.

- Effects of capsaicin on testis ghrelin expression in mice - PubMed

 

[Ras]

In this study Capsicin had a huge effect on testosterone in mice. When given to pubertal mice for 40 days it increased T about 1,5 fold , but the real magic happened in the adult animals that got the pepper for 70 days: they increased their T by 2,5 fold!
I'm not sure how the dosage correlates to HED but the researchers called it a low dose (0.02%) , but I think that is a relativeley high dose. But lower doses might still be effective, they just didn't look for it.

I remember @Lokzo posted a study on a very androgenic pepper , maybe it was realted to its capsaicin content.
@cs3000 you'll want to see this.
View attachment 55455
- Effects of capsaicin on testis ghrelin expression in mice - PubMed

That study is reviewed here: On a diet? Capsaicin keeps your testosterone level up

 

[Mauritio]

In this in vitro study capsaicin increased the expression of the androgen receptor.

"Capsaicin induced an increase in the AR expression that was reverted by the three TRPV1 antagonists."

- Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells - PubMed

 

[cs3000]

damn wild result. yeh dose would be damaging to gut cells

this one showed the opposite on low dose for some reason? without toxicity , 7 days

https://www.researchgate.net/publication/281381103_Expression_of_a_capsaicin_receptor_VR1_in_the_testes_of_mice_after_an_application_of_capsaicin

1mg/kg subcutaneously their test went down -50% (think subcutaneous & oral bioavailability is similar for capsaicin) , but only applied to the younger groups
So is the difference:
- inverse effect with low dose? or
- only lowers test during youth in development and raises when older? (no, 1st study saw test increase in both ages) or
- something else like does the VR1 (aka TRPV1) receptor get rekt when taken for long enough for opposite effect on testosterone? the older mice who had less vr1/TRPV1 got a test increase. that study was 7 days , wonder how long the 1st was for. test downregulates TRPV1 expression if that plays into it somehow


[their bodyweights went up & in the 1st study it raised ghrelin
so could be useful substance for restoring appetite , thanks]

but here Some like it hot: Testosterone predicts laboratory eating behavior of spicy food
spicy food preference correlates with test in men

 

[Mauritio]

damn wild result. yeh dose would be damaging to gut cells

this one showed the opposite on low dose for some reason? without toxicity , 7 days

https://www.researchgate.net/publication/281381103_Expression_of_a_capsaicin_receptor_VR1_in_the_testes_of_mice_after_an_application_of_capsaicin

1mg/kg subcutaneously their test went down -50% (think subcutaneous & oral bioavailability is similar for capsaicin) , but only applied to the younger groups
So is the difference:
- inverse effect with low dose? or
- only lowers test during youth in development and raises when older? (no, 1st study saw test increase in both ages) or
- something else like does the VR1 (aka TRPV1) receptor get rekt when taken for long enough for opposite effect on testosterone? the older mice who had less vr1/TRPV1 got a test increase. that study was 7 days , wonder how long the 1st was for. test downregulates TRPV1 expression if that plays into it somehow


[their bodyweights went up & in the 1st study it raised ghrelin
so could be useful substance for restoring appetite , thanks]

but here Some like it hot: Testosterone predicts laboratory eating behavior of spicy food
spicy food preference correlates with test in men

One might try capsaicin on the penis or scrotum dissolved in mct, if they are brave lol, penis is probably safer . But that would enable you to get around damaging the gut and it would also have less of an systemic NO increase.

 

[Elie]

Recently I has to dive a bit deeper into natural agent that increase testosterone. What I noticed was that the results in animals typically are far greater than in humans.
The typical range if increased T in humans with medicinal plants us 15%-20% (with those that work)

 

[A-Tim]

One might try capsaicin on the penis or scrotum dissolved in mct, if they are brave lol, penis is probably safer . But that would enable you to get around damaging the gut and it would also have less of an systemic NO increase.

Not all heroes wear capes

 

[Mauritio]

Not all heroes wear capes

Not the hero we wanted, but the hero we needed ...

 

[cs3000]

Not the hero we wanted, but the hero we needed ...

Not all heroes wear capes

tried & can confirm , after dipping them in the powder i grew a full beard (on my nuts)

 

[A-Tim]

We salute you