Mauritio
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- Feb 26, 2018
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A few days ago I did a post on 2-bromo-LSD as a better LSD alternative .
2-bromo-lsd ,lacks the hallucinogenic effect of LSD ,which might be due to a stronger anti-serotonin effect .
The problem is: it is very hard to get and pretty expensive, plus its illegal .
Today I stumbled upon1-acetyl-LSD ,which is commonly sold as an LSD prodrug. It seems to be the case that it does have slightly different binding affinities to certain receptor and thus might be more or less serotonergic .
As it turns it it might be more anti-serotonergic ! This is what wikipedia says on it:
" The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.
One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent"
So Hoffer himself confirms stronger anti-serotonin effects than with LSD.
Coincidentally theres a very recent study that supports the claim that it is less serotonergic/ more anti-serotonergic. Remember a good chunk of it is going to end up as LSD ,so there is going to be hallucinations, but it seems that this is a less serotonergic alternative to LSD .
"1-Acyl-substitution reduced the affinity of LSD for most monoamine receptors, including 5-HT2A sites, by one to two orders of magnitude. Although LSD acts as an agonist at 5-HT2 subtypes, ALD-52, 1P-LSD and 1B-LSD have weak efficacy or act as antagonists in Ca2+-mobilization assays."
From an article :
"The data showed that ALD-52, 1P-LSD, and 1B-LSD were very weak partial agonists at the human 5-HT2A compared to LSD. Interestingly, despite showing comparatively high affinity for 5-HT2B and 5-HT2C, the compounds showed no agonist activity at those receptors. This behavior is in contrast to LSD, which is an agonist at recombinant human 5-HT2B and 5-HT2C receptors."
This means that ALD52 is an antagonist at 5ht2b and c ! Plus a its just a very weak agonist on 5ht2a . Awesome.
Here's a report of guy who says that uses ald52 to get rid of his cluster headaches. Which are probably caused by serotonin .
This study shows that 1-acetyl-LSD, which is ALD52 ,is less potent at elevating brain serotonin and 2-bromo-lsd is actually even less potent at that .
Last but not least ALD52/ 1-acetyl-LSD is legal or at least tolerated in most countries. Which makes it a great legal LSD and 2-bromo-lsd alternative with a stronger anti-serotonin effect .
2-bromo-lsd still seems to be a bit stronger, but for now we have to go with ALD52.
2-bromo-lsd ,lacks the hallucinogenic effect of LSD ,which might be due to a stronger anti-serotonin effect .
The problem is: it is very hard to get and pretty expensive, plus its illegal .
Today I stumbled upon1-acetyl-LSD ,which is commonly sold as an LSD prodrug. It seems to be the case that it does have slightly different binding affinities to certain receptor and thus might be more or less serotonergic .
As it turns it it might be more anti-serotonergic ! This is what wikipedia says on it:
" The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.
One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent"
So Hoffer himself confirms stronger anti-serotonin effects than with LSD.
Coincidentally theres a very recent study that supports the claim that it is less serotonergic/ more anti-serotonergic. Remember a good chunk of it is going to end up as LSD ,so there is going to be hallucinations, but it seems that this is a less serotonergic alternative to LSD .
"1-Acyl-substitution reduced the affinity of LSD for most monoamine receptors, including 5-HT2A sites, by one to two orders of magnitude. Although LSD acts as an agonist at 5-HT2 subtypes, ALD-52, 1P-LSD and 1B-LSD have weak efficacy or act as antagonists in Ca2+-mobilization assays."
Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)
The ergoline d-lysergic acid diethylamide (LSD) is one of the most potent psychedelic drugs. 1-Acetyl-LSD (ALD-52), a derivative of LSD containing an …
www.sciencedirect.com
From an article :
"The data showed that ALD-52, 1P-LSD, and 1B-LSD were very weak partial agonists at the human 5-HT2A compared to LSD. Interestingly, despite showing comparatively high affinity for 5-HT2B and 5-HT2C, the compounds showed no agonist activity at those receptors. This behavior is in contrast to LSD, which is an agonist at recombinant human 5-HT2B and 5-HT2C receptors."
Study Finds ALD-52, 1P-LSD, and 1B-LSD Are Prodrugs of LSD
Identifying and understanding prodrugs is an essential component of psychedelic drug research.
psychedelicreview.com
This means that ALD52 is an antagonist at 5ht2b and c ! Plus a its just a very weak agonist on 5ht2a . Awesome.
Here's a report of guy who says that uses ald52 to get rid of his cluster headaches. Which are probably caused by serotonin .
2-bromo-lsd
We have 3 proven inexpensive treatments that are not toxic to your body. In the navy I worked in the water lab. We used bromine to decontaminate sea water before sent to flash evaporation. We had to where haz-mat equipment to handle the bromine! I believe the Shulgin's might agree and stick to wh...
clusterbusters.org
This study shows that 1-acetyl-LSD, which is ALD52 ,is less potent at elevating brain serotonin and 2-bromo-lsd is actually even less potent at that .
EFFECTS OF LSD-25 ON BRAIN SEROTONIN
LSD-25 in doses of 130 to 1300 µg/kg induced a small and significant rise in levels of rat brain serotonin within 10 to 120 minutes following administration. A single dose was as effective as several daily doses. In reserpine treated animals, LSD-25 induced a 2-fold elevation in brain serotonin...
jpet.aspetjournals.org
Last but not least ALD52/ 1-acetyl-LSD is legal or at least tolerated in most countries. Which makes it a great legal LSD and 2-bromo-lsd alternative with a stronger anti-serotonin effect .
2-bromo-lsd still seems to be a bit stronger, but for now we have to go with ALD52.
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