Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
While researching 6methoxyharmalan I came across a reference from the sixties that said :
"Bromo-lysergic
Acid diethylamide, for example, is a
potent serotonin antagonist, yet has lit-
tle psychotomimetic action."
So it's a strong serotonin antagonist ,like LSD, but it has not been shown to induce hallucinations
Peat said that LSD is anti-serotonin chemical, but that the hallucinations are actually caused by serotonin. So a lack of hallucinations stands for a lack of serotonergic action in 2-bromo-lsd .
From another study:
"lysergic acid diethylamide but not BOL had a highly potent serotonin agonist-like inhibitory action
on serotonergic neurones,.."
"Finally, in biochemical studies, LSD has considerably more potency
in increasing brain 5-HT levels and reducing 5HT
turnover (FREEDMAN, 1961; AND~N, CORRODI, FUXE and HBKFELT, 1968)."
So it seems to be less serotonergic in some ways, but a little less strong at inhibiting it presumably at other 5ht receptors:
"On the other hand, a number of physiological and biochemical studies indicate a greater potencyfor LSD than its 2-bromo derivative."
pubmed.ncbi.nlm.nih.gov
Here you can see that it's actually a 5ht2a antagonist , as opposed to LSD ,whis is an agonist at that receptor . This is why it has been shown to stop LSDs effect (hallucination) similarly to Lisuride . It seems to have similar effects to lisuride but I'd still be interested in trying it ...
psychedelicreview.com
"Bromo-lysergic
Acid diethylamide, for example, is a
potent serotonin antagonist, yet has lit-
tle psychotomimetic action."
So it's a strong serotonin antagonist ,like LSD, but it has not been shown to induce hallucinations
Peat said that LSD is anti-serotonin chemical, but that the hallucinations are actually caused by serotonin. So a lack of hallucinations stands for a lack of serotonergic action in 2-bromo-lsd .
From another study:
"lysergic acid diethylamide but not BOL had a highly potent serotonin agonist-like inhibitory action
on serotonergic neurones,.."
"Finally, in biochemical studies, LSD has considerably more potency
in increasing brain 5-HT levels and reducing 5HT
turnover (FREEDMAN, 1961; AND~N, CORRODI, FUXE and HBKFELT, 1968)."
So it seems to be less serotonergic in some ways, but a little less strong at inhibiting it presumably at other 5ht receptors:
"On the other hand, a number of physiological and biochemical studies indicate a greater potencyfor LSD than its 2-bromo derivative."
LSD and 2-bromo-LSD: comparison on effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala - PubMed
LSD and 2-bromo-LSD: comparison on effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala
pubmed.ncbi.nlm.nih.gov
Here you can see that it's actually a 5ht2a antagonist , as opposed to LSD ,whis is an agonist at that receptor . This is why it has been shown to stop LSDs effect (hallucination) similarly to Lisuride . It seems to have similar effects to lisuride but I'd still be interested in trying it ...
| Receptor | Ki (nM) | Species | Ref. |
|---|---|---|---|
| 5-HT2A | =0.48 | Human | 8 |
| 5-HT2B | =8.56 | Human | 8 |
| 5-HT2C | =7.14 | Human | 8 |
| 5-HT6 | =17.1 | Human | 9 |
| 5-HT7 | =30.0 | Human | 9 |
2-Bromo-LSD
2-Bromo-LSD was synthesized by Albert Hofmann in 1957. Unlike LSD, it does not have psychedelic effects.
psychedelicreview.com
