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- Aug 24, 2017
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I have noticed a few people on the forum questioning if you can build muscle on a lowish fat, low PUFA diet as you need inflammation to grow muscles.
Also, that taking NSAID like aspirin would hamper muscle protein synthesis due to inhibiting COX and therefor inflammation.
Well there are studies which show that aspirin significantly aids in muscle regeneration and growth in older men, and that it didn't hinder muscle protein synthesis in short term use in untrained men.
Well, I think the following study is worth a mention...
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperaminoacidemia-hyperinsulinemia in healthy young and middle aged men and women
One group took 4g omega 3 for 8 weeks. (Omega 3 displaces arachidonic acid from phospholipids and will result in less inflammation compared to those having more omega 6 in their phospholipids.)
But the omega 3 supplementation didn't hamper muscle protein synthesis, but it would rather seem to have increased it, by means of improving insulin sensitivity. (Image attached.)
Hence a low PUFA diet will not hinder muscle protein synthesis by means of less inflammation, but it would rather seem that muscle growth comes from the ability to regenerate, via internal mechanisms, and not via inflammation.
Anti-oxidants should be avoided a few hours before or after a workout as that will hinder the body's natural ability to heal itself, but I think inflammation is unnecassary for muscle growth. PUFAs are anyway pro-estrogen, pro-cortisol and therefor catabolic, etc. whereas SFAs are anabolic and will aid in better muscle function, integrity and anabolic stimulis.
What do you guys think? Counter and/or complementory studies/arguments welcome.
Also, that taking NSAID like aspirin would hamper muscle protein synthesis due to inhibiting COX and therefor inflammation.
Well there are studies which show that aspirin significantly aids in muscle regeneration and growth in older men, and that it didn't hinder muscle protein synthesis in short term use in untrained men.
Well, I think the following study is worth a mention...
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperaminoacidemia-hyperinsulinemia in healthy young and middle aged men and women
One group took 4g omega 3 for 8 weeks. (Omega 3 displaces arachidonic acid from phospholipids and will result in less inflammation compared to those having more omega 6 in their phospholipids.)
But the omega 3 supplementation didn't hamper muscle protein synthesis, but it would rather seem to have increased it, by means of improving insulin sensitivity. (Image attached.)
Hence a low PUFA diet will not hinder muscle protein synthesis by means of less inflammation, but it would rather seem that muscle growth comes from the ability to regenerate, via internal mechanisms, and not via inflammation.
Anti-oxidants should be avoided a few hours before or after a workout as that will hinder the body's natural ability to heal itself, but I think inflammation is unnecassary for muscle growth. PUFAs are anyway pro-estrogen, pro-cortisol and therefor catabolic, etc. whereas SFAs are anabolic and will aid in better muscle function, integrity and anabolic stimulis.
What do you guys think? Counter and/or complementory studies/arguments welcome.