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Well, the body does produce ROS via a few mechanisms, which includes the mitochondria, NADPH oxidase (NOX), xanthine oxidase, myostatin, phospholipase A2, COX and LOX.@Hans, what do you think about this article: Are Bigger Muscles Better? Antioxidants and the Response to Exercise - Perfect Health Diet | Perfect Health Diet
Being on a low PUFA diet will significantly lower ROS, LPO, prostaglandins, etc., and doesn't inhibit hypertrophy as far as I know, but will actually boost it because PUFAs are catabolic and anti-androgenic whereas saturated fats are anabolic and androgenic. Caffeine inhibits xanthine oxidase and can actually promote hypertrophy. Myostatin is a negative regulator of muscle growth.
A moderate acute spurt of ROS seems to be needed to promote adaption from exercise, whereas excessive and prolonged elevated ROS promotes proteolysis, so depleting anti-oxidants would definitely be silly.
Impact of Oxidative Stress on Exercising Skeletal Muscle
"Strong increases in ROS after strenuous exercise, aging and/or disease (e.g., chronic heart failure, COPD, cancer) can cause contractile dysfunction and muscle atrophy, which both promote muscle weakness and fatigue"
Mostly only during overtraining and malnutrition could ROS get out of hand and start causing some serious damage.
Eating a good diet which contains natural anti-oxidants should be enough to support weight training. I also think that a lot of supplemental anti-oxidants close to and around the workout will blunt the adaption, but taking the anti-oxidants on off days or 12+ hours away from your workouts should not interfere. I take my vitamin E on my off days only. Vince Gironda took large doses of vitamin E (400-1600IU) daily with about 300-500mg of vitamin C and he was all about what produced results. So I'm sure he wouldn't have done it if it was blunting his gains. But probably a big reason why he took so much was because he ate lots of eggs when bulking.
I think depleting yourself of anti-oxidants with the idea to get bigger, will actually cause atrophy, not hypertrophy. Maybe cell swelling from all the inflammation, but not hypertrophy. DHEA also increase the production of ROS, which seems to be highly beneficial. A little bit of ROS is also needed for insulin signaling. So ROS is needed, but excessive is bad.
Plus, trained men can tolerate ROS much better than untrained men, because they have adapted to it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496677/bin/biomolecules-05-00356-g002.jpg