Thiamine, histamine, and hypothermia

[Vinero]

It seems that a thiamine deficiency, also known as vitamin B1, can have some undesirable consequences such as:
-Increased histamine levels: http://link.springer.com/article/10.1007%2FBF01997372
-Low body temperature: http://www.ncbi.nlm.nih.gov/pubmed/2090843

Haidut already posted studies about how thiamine can cure Crohn's/IBS, MS fatigue, and Alzheimers in massive doses ranging from 500mg-1500mg every 4 hours. The sufferers in the studies weren't deficient in thiamine according to bloodtests, yet benefited from supplementation.
The standards for adequate thiamine are simply too low; or the body has trouble getting thiamine into the cells despite normal blood levels.
So, if your still having low temperatures, stomach problems, and excess histamine despite doing everything right, you might have a mild thiamine deficiency going on. Especially if you are eating a lot of white sugar, caffeine, aspirin, etc which stimulate metabolism deepening the thiamine deficiency.

 

[Suikerbuik]

Hate all those new started topics about the same subject (in this case B1) :)

Here's Haidut's original post:
http://www.raypeatforum.com/forum/viewtopic.php?f=10&t=2669

Doubt it cures disease, but it seems to regress fatigue considerably. Would love to know if there's indeed a reduced transport and why. But there's more mechanisms involved, certainly interesting stuff that B1!

Genetic studies have provided opportunities to determine which proteins may link thiamine to cancer pathology, including SLC19 gene, transketolase, transcription factor p53, PARP, and NOX. Thiamine can also act through a number of non-genomic mechanisms, which include protein expression, oxidative stress, inflammation, and cellular metabolism.

http://cgp.iiarjournals.org/content/10/4/169.full

To make the picture more complete:
Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.
http://www.ncbi.nlm.nih.gov/pubmed/23379830

High dose thiamine improves fatigue in multiple sclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/23861280

Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain.
http://www.ncbi.nlm.nih.gov/pubmed/19576514

Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability.http://www.ncbi.nlm.nih.gov/pubmed/15082221

Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide.
http://www.ncbi.nlm.nih.gov/pubmed/18481165

 

[jyb]

Those studies showing benefits tend to be with quite high doses of thiamine, but not all, so I'm not sure what to think given this thread

http://www.raypeatforum.com/forum/viewtopic.php?f=10&t=2783&p=35730

 

[Candeias]

It seems that a thiamine deficiency, also known as vitamin B1, can have some undesirable consequences such as:
-Increased histamine levels: Increased neuronal histamine in thiamine-deficient rats - Inflammation Research
-Low body temperature: Effects of thiamine administration on hypothermia and hypothalamic histamine levels in dietary-induced thiamine deficient rats - PubMed

Haidut already posted studies about how thiamine can cure Crohn's/IBS, MS fatigue, and Alzheimers in massive doses ranging from 500mg-1500mg every 4 hours. The sufferers in the studies weren't deficient in thiamine according to bloodtests, yet benefited from supplementation.
The standards for adequate thiamine are simply too low; or the body has trouble getting thiamine into the cells despite normal blood levels.
So, if your still having low temperatures, stomach problems, and excess histamine despite doing everything right, you might have a mild thiamine deficiency going on. Especially if you are eating a lot of white sugar, caffeine, aspirin, etc which stimulate metabolism deepening the thiamine deficiency.

You are completely right, I caused a thiamine deficiency just one day after using a super high dose of Pterostilbene, the symptoms were very cold body, heartburn and muscle pain.