I definitely think you can address it directly to see if it helps any. I'd probably try out pregnenolone/progesterone/DHEA/T3 and magnesium to see if it helps.
Rough stuff. Have you tried anticholinergics?
There are many anticholinergic drugs and honestly, I don't think it's the anticholinergic effect that leads to dementia. These drugs have many other effects as well, such as increasing serotonin.
From this study:
Anticholinergic drugs and risk of dementia: case-control study
"A total of 1 793 505 prescriptions for drugs with an ACB score of 3 were written during the DEP. The five most common drugs were amitriptyline (29%), dosulepin (also known as dothiepin; 16%), paroxetine (8%), oxybutynin (7%), and tolterodine (7%)."
"there was a significant association between dementia incidence and any prescription of antidepressant, antiparkinson, or urological drugs with an ACB score of 3, but no association with antispasmodic, antipsychotic, antihistamine, or other drugs with an ACB score of 3. Prescriptions for drugs with an ACB score of 2 were relatively rare"
"In this case-control study of older adults in the UK, there was a noticeable association between increasing total anticholinergic burden over the previous 4-20 years and incident dementia diagnosis. However, this dose-response effect was not seen for cumulative use of drugs with an Anticholinergic Cognitive Burden (ACB) score of 1 (possibly anticholinergic), and was only evident for certain classes of anticholinergic drugs"
"Antidepressants (predominantly amitriptyline, dosulepin, and paroxetine) and urologicals (predominantly oxybutynin and tolterodine) with an ABC score of 3 (definitely anticholinergic) were consistently associated with incident dementia."
"Prescription of gastrointestinal drugs with an ACB score of 3 was not positively associated with dementia in any of our analyses. Other antidepressants (predominantly selective serotonin reuptake inhibitors) with an ACB score of 1 were associated with dementia, but that association was greater for prescriptions close to dementia incidence, suggesting that reverse causation could be a possible explanation for this observed association."
So it's more likely to be serotonin that's involved in dementia. Haidut made a thread about this: Higher Serotonin Availability May Be The Cause Of Cognitive Impairment / Dementia
I wonder if acetylcholine is actually high in the brain as some sort of protective measure and is actually getting the blame for symptoms. A bit like DHT and balding, and inflammation and O3.
Interesting thought - only acetylcholine seems to be a direct cause of some or many of the symptoms just as part of its function in various concentrations.
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