The High Acetylcholine Syndrome

Discussion in 'Articles & Scientific Studies' started by Hans, Jun 26, 2020.

  1. Hans

    Hans Member

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    I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it.

    The high acetylcholine syndrome » MenElite
     
  2. Tristan Loscha

    Tristan Loscha Member

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    Very good work!
     
  3. 2ManyHistamines

    2ManyHistamines Member

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    Thank You Hans!
     
  4. james2388

    james2388 Guest

    B1 deficiency is very much tied to low acetylcholine
     
  5. OP
    Hans

    Hans Member

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    Thanks!
    My pleasure man.
    Indeed so.
     
  6. Frankdee20

    Frankdee20 Member

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    Funny how people consume CDP and GPC choline and smart drugs, but too much choline dulls the mind
     
  7. Peater

    Peater Member

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    This is great Hans. Is there a way of testing acetylcholine levels in the brain and blood? I suffer from sweating easily. At the moment it seems to responding well to 5aDHP and CBD/CBDA (20mg 3x a day). I am waiting to update the thread about sweating once I am satisfied it is a definite correlation. Interesting to see sage mentioned there. I thought it helped for a bit, but in the end it did not.

    I have cut out other supplements to be as accurate as possible, apart from camphosal in the evening before bed (Started 2 weeks into my 5aDHP/CBD experiment)
     
  8. erho

    erho Member

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    @Hans Do you think that with OCD this is something one might want to effect through diet and supplements, or leave it and just look at the big picture? You do mention implications on OCD by different factors on your website sometimes, I really appreciate that, thanks.
     
  9. OP
    Hans

    Hans Member

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    I definitely think you can address it directly to see if it helps any. I'd probably try out pregnenolone/progesterone/DHEA/T3 and magnesium to see if it helps.
     
  10. rebuke

    rebuke Member

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    A single dose of Alpha GPC made me feel suicidal almost instantly. I had to lay down and sleep it off.
     
  11. OP
    Hans

    Hans Member

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    Rough stuff. Have you tried anticholinergics?
     
  12. Frankdee20

    Frankdee20 Member

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    Choline can induce severe depressions
     
  13. Frankdee20

    Frankdee20 Member

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    What do you think about the correlation between use of anti cholinergics like Bendedryl and antihistamines and dementia risk ? I really do like doxylamine succinate half a tablet sometimes at night to help me sleep.... I don’t develop tolerance and I think one tablet is very strong and makes me dopey the next day.... but I’m concerned
     
  14. OP
    Hans

    Hans Member

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    There are many anticholinergic drugs and honestly, I don't think it's the anticholinergic effect that leads to dementia. These drugs have many other effects as well, such as increasing serotonin.

    From this study:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915701/
    "A total of 1 793 505 prescriptions for drugs with an ACB score of 3 were written during the DEP. The five most common drugs were amitriptyline (29%), dosulepin (also known as dothiepin; 16%), paroxetine (8%), oxybutynin (7%), and tolterodine (7%)."

    "there was a significant association between dementia incidence and any prescription of antidepressant, antiparkinson, or urological drugs with an ACB score of 3, but no association with antispasmodic, antipsychotic, antihistamine, or other drugs with an ACB score of 3. Prescriptions for drugs with an ACB score of 2 were relatively rare"

    "In this case-control study of older adults in the UK, there was a noticeable association between increasing total anticholinergic burden over the previous 4-20 years and incident dementia diagnosis. However, this dose-response effect was not seen for cumulative use of drugs with an Anticholinergic Cognitive Burden (ACB) score of 1 (possibly anticholinergic), and was only evident for certain classes of anticholinergic drugs"

    "Antidepressants (predominantly amitriptyline, dosulepin, and paroxetine) and urologicals (predominantly oxybutynin and tolterodine) with an ABC score of 3 (definitely anticholinergic) were consistently associated with incident dementia."

    "Prescription of gastrointestinal drugs with an ACB score of 3 was not positively associated with dementia in any of our analyses. Other antidepressants (predominantly selective serotonin reuptake inhibitors) with an ACB score of 1 were associated with dementia, but that association was greater for prescriptions close to dementia incidence, suggesting that reverse causation could be a possible explanation for this observed association."

    So it's more likely to be serotonin that's involved in dementia. Haidut made a thread about this: Higher Serotonin Availability May Be The Cause Of Cognitive Impairment / Dementia
     
  15. Frankdee20

    Frankdee20 Member

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    Yeah, doxylamine has zero affinity for serotonin and mostly just histamine and Muscarine cholinergic antagonism ... thanks
     
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