Currently I am experiencing fatigue (mostly in the afternoons, for 5 years), palinopsia (of illusory type: seeing afterimages of high contrast objects, for 2 years), mild anxiety (specially in the morning), waking up around 5:00 with palpitations and buzzing body, tired and hollow eyes after meals, bloating after some meals, and very occasional episodes of mild dizziness (worse in hot weather). I get stressed quite easily.
A few days ago, a "precision medicine" doctor, told me I had dysautonomia with an underactive parasympathetic system and low acetylcholine and low DHEA. He thinks that sympathetic overactivity causes my fatigue. This diagnostic was partly based on the interpretation of heart rate variability, blood pressure and bioelectrical impedance measured by a computerized system (ES Teck Complex System). Although the dysautonomia diagnostic seems to match my symptoms, I don't know to what extent I can trust the low acetylcholine assumption, since it was "calculated" and not measured directly.
The doctor wants to increase my acetylcholine and DHEA levels and has prescribed me various supplement complexes (soy lecithin, L-alpha glycerylphosphorylcholine, huperzine A [cholinesterase inhibitor], L-tyrosine, phosphatidylserine, and DHEA among others) and practices for stimulating the vagus nerve. I have read the risks of promoting acetylcholine in Ray Peat's article "The dark side of stress (learned helplessness)", stating that high acetylcholine is involved in Alzheimer and Parkinson. So I am quite confused at this point.
I am also worried that these symptoms could lead to a neurodegenerative state. I don't want to mess things up
During the last year, some out of range values that have been found in my tests are: low neutrophils, low platelet count, low copper (hair and blood), top of range calcium (blood), high selenium (blood), high zinc (blood and hair), high magnesium (in hair, top of range in erithrocites), high boron (hair), low DHEA (saliva), low cortisol (only in the saliva afternoon measure), high lactate:pyruvate ratio (blood), high superoxide dismutase (blood), high glutamine (urine organic acids), high noradrenaline (urine organic acids), high adrenaline (urine organic acids) and low GABA (urine organic acids)
How does one know if there is an acetylcholine deficiency since it can not be measured directly as far as I know?
Has anybody been in a similar situation?
How can I stimulate parasympathetic activity and tame sympathetic activity?
A few days ago, a "precision medicine" doctor, told me I had dysautonomia with an underactive parasympathetic system and low acetylcholine and low DHEA. He thinks that sympathetic overactivity causes my fatigue. This diagnostic was partly based on the interpretation of heart rate variability, blood pressure and bioelectrical impedance measured by a computerized system (ES Teck Complex System). Although the dysautonomia diagnostic seems to match my symptoms, I don't know to what extent I can trust the low acetylcholine assumption, since it was "calculated" and not measured directly.
The doctor wants to increase my acetylcholine and DHEA levels and has prescribed me various supplement complexes (soy lecithin, L-alpha glycerylphosphorylcholine, huperzine A [cholinesterase inhibitor], L-tyrosine, phosphatidylserine, and DHEA among others) and practices for stimulating the vagus nerve. I have read the risks of promoting acetylcholine in Ray Peat's article "The dark side of stress (learned helplessness)", stating that high acetylcholine is involved in Alzheimer and Parkinson. So I am quite confused at this point.
I am also worried that these symptoms could lead to a neurodegenerative state. I don't want to mess things up
During the last year, some out of range values that have been found in my tests are: low neutrophils, low platelet count, low copper (hair and blood), top of range calcium (blood), high selenium (blood), high zinc (blood and hair), high magnesium (in hair, top of range in erithrocites), high boron (hair), low DHEA (saliva), low cortisol (only in the saliva afternoon measure), high lactate:pyruvate ratio (blood), high superoxide dismutase (blood), high glutamine (urine organic acids), high noradrenaline (urine organic acids), high adrenaline (urine organic acids) and low GABA (urine organic acids)
How does one know if there is an acetylcholine deficiency since it can not be measured directly as far as I know?
Has anybody been in a similar situation?
How can I stimulate parasympathetic activity and tame sympathetic activity?